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Hylemon PB, Takabe K, Dozmorov M, et al. Bile acids as global regulators of hepatic nutrient metabolism. Liver Res. 2017;1(1):10-16doi: 10.1016/j.livres.2017.03.002.
Hylemon, P. B., Takabe, K., Dozmorov, M., Nagahashi, M., & Zhou, H. (2017). Bile acids as global regulators of hepatic nutrient metabolism. Liver research, 1(1), 10-16. https://doi.org/10.1016/j.livres.2017.03.002
Hylemon, Phillip B, et al. "Bile acids as global regulators of hepatic nutrient metabolism." Liver research vol. 1,1 (2017): 10-16. doi: https://doi.org/10.1016/j.livres.2017.03.002
Hylemon PB, Takabe K, Dozmorov M, Nagahashi M, Zhou H. Bile acids as global regulators of hepatic nutrient metabolism. Liver Res. 2017 Jun;1(1):10-16. doi: 10.1016/j.livres.2017.03.002. Epub 2017 Apr 26. PMID: 29123941; PMCID: PMC5673281.
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Liver Res. 2017 Jun;1(1):10-16. doi: 10.1016/j.livres.2017.03.002. Epub 2017 Apr 26.

Bile acids as global regulators of hepatic nutrient metabolism.

Liver research

Phillip B Hylemon, Kazuaki Takabe, Mikhail Dozmorov, Masayuki Nagahashi, Huiping Zhou

Affiliations

  1. Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA.
  2. McGuire VA Medical Center, Richmond, VA 23249, USA.
  3. Department of Surgery, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA.
  4. Department of Biostatistics, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA.
  5. Department of Surgery, Niigata University, Japan.

PMID: 29123941 PMCID: PMC5673281 DOI: 10.1016/j.livres.2017.03.002

Abstract

Bile acids (BA) are synthesized from cholesterol in the liver. They are essential for promotion of the absorption of lipids, cholesterol, and lipid-soluble vitamins from the intestines. BAs are hormones that regulate nutrient metabolism by activating nuclear receptors (farnesoid X receptor (FXR), pregnane X receptor, vitamin D) and G protein-coupled receptors (e.g., TGR5, sphingosine-1-phosphate receptor 2 (S1PR2)) in the liver and intestines. In the liver, S1PR2 activation by conjugated BAs activates the extracellular signal-regulated kinase 1/2 and AKT signaling pathways, and nuclear sphingosine kinase 2. The latter produces sphingosine-1-phosphate (S1P), an inhibitor of histone deacetylases 1/2, which allows for the differential up-regulation of expression of genes involved in the metabolism of sterols and lipids. We discuss here the emerging concepts of the interactions of BAs, FXR, insulin, S1P signaling and nutrient metabolism.

Keywords: Epigenetics; Fatty liver; Sphingosine kinase 2; Sphingosine-1-phosphate; Sphingosine-1-phosphate receptor 2

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