Display options
Cite
Iseme RA, Mcevoy M, Kelly B, et al. Is osteoporosis an autoimmune mediated disorder?. Bone Rep. 2017;7:121-131doi: 10.1016/j.bonr.2017.10.003.
Iseme, R. A., Mcevoy, M., Kelly, B., Agnew, L., Walker, F. R., & Attia, J. (2017). Is osteoporosis an autoimmune mediated disorder?. Bone reports, 7121-131. https://doi.org/10.1016/j.bonr.2017.10.003
Iseme, Rosebella A, et al. "Is osteoporosis an autoimmune mediated disorder?." Bone reports vol. 7 (2017): 121-131. doi: https://doi.org/10.1016/j.bonr.2017.10.003
Iseme RA, Mcevoy M, Kelly B, Agnew L, Walker FR, Attia J. Is osteoporosis an autoimmune mediated disorder?. Bone Rep. 2017 Oct 16;7:121-131. doi: 10.1016/j.bonr.2017.10.003. eCollection 2017 Dec. PMID: 29124082; PMCID: PMC5671387.
Copy Download .nbib Format: NLM
Share it on

Bone Rep. 2017 Oct 16;7:121-131. doi: 10.1016/j.bonr.2017.10.003. eCollection 2017 Dec.

Is osteoporosis an autoimmune mediated disorder?.

Bone reports

Rosebella A Iseme, Mark Mcevoy, Brian Kelly, Linda Agnew, Frederick R Walker, John Attia

Affiliations

  1. Department of Population and Reproductive Health, School of Public Health, Kenyatta University, P.O. Box 43844 -, 00100, Nairobi, Kenya.
  2. School of Medicine & Public Health, The University of Newcastle, Callaghan, NSW, 2308, Australia.
  3. Hunter Medical Research Institute, Kookaburra Circuit, New Lambton Heights, NSW, 2305, Australia.
  4. Centre for Brain and Mental Health Research, The University of Newcastle, Callaghan, NSW, Australia.
  5. Brain Behaviour Research Group, School of Science and Technology, University of New England, Armidale, NSW 2351, Australia.
  6. Laboratory of Affective Neuroscience, The University of Newcastle, Callaghan, NSW, Australia.
  7. University of Newcastle, Medical Sciences MS413, University Drive, Callaghan, NSW 2308, Australia.
  8. Department of General Medicine, John Hunter Hospital, New Lambton Heights, NSW, Australia.

PMID: 29124082 PMCID: PMC5671387 DOI: 10.1016/j.bonr.2017.10.003

Abstract

The last two decades have marked a growing understanding of the interaction occurring between bone and immune cells. The chronic inflammation and immune system dysfunction commonly observed to occur during the ageing process and as part of a range of other pathological conditions, commonly associated with osteoporosis has led to the recognition of these processes as important determinants of bone disease. This is further supported by the recognition that the immune and bone systems in fact share regulatory mechanisms and progenitor molecules. Research into this complex synergy has provided a better understanding of the immunopathogenesis underlying bone diseases such as osteoporosis. However, existing research has largely focussed on delineating the role played by inflammation in pathogenic bone destruction, despite increasing evidence implicating autoantibodies as important drivers of osteoporosis. This review shall attempt to provide a comprehensive overview of existing research examining the role played by autoantibodies in osteoporosis in order to determine the potential for further research in this area. Autoantibodies represent promising targets for the improved treatment and diagnosis of inflammatory bone loss.

Keywords: Autoantibodies; Bone mineral density; Bone remodelling; Fractures; Osteoporosis

References

  1. Am J Respir Crit Care Med. 2010 Jun 15;181(12):1329-35 - PubMed
  2. Clin Rev Allergy Immunol. 2016 Aug;51(1):27-47 - PubMed
  3. Calcif Tissue Int. 2015 Aug;97(2):125-33 - PubMed
  4. Clin Cases Miner Bone Metab. 2013 Jan;10(1):47-51 - PubMed
  5. Biomed Res Int. 2014;2014:965764 - PubMed
  6. Clin Gastroenterol Hepatol. 2015 May;13(5):913-20.e5 - PubMed
  7. Am J Manag Care. 2011 May;17 Suppl 6:S164-9 - PubMed
  8. Clin Dev Immunol. 2013;2013:720504 - PubMed
  9. Autoimmun Rev. 2009 Jan;8(3):250-5 - PubMed
  10. Int Rev Cell Mol Biol. 2013;301:215-90 - PubMed
  11. Radiol Clin North Am. 2010 May;48(3):483-95 - PubMed
  12. Rheumatol Int. 2012 Oct;32(10 ):3143-8 - PubMed
  13. Ann Transl Med. 2015 Jul;3(12):163 - PubMed
  14. Exp Cell Res. 2007 Jan 1;313(1):168-78 - PubMed
  15. Can J Gastroenterol. 2010 Feb;24(2):103-7 - PubMed
  16. Lupus. 2006;15(11):737-45 - PubMed
  17. Postgrad Med J. 2000 Aug;76(898):466-8 - PubMed
  18. J Biol Chem. 2010 Aug 13;285(33):25103-8 - PubMed
  19. Ann Rheum Dis. 2014 Nov;73(11):2022-8 - PubMed
  20. Immun Ageing. 2005 Nov 04;2:14 - PubMed
  21. Ann Rheum Dis. 2005 Aug;64(8):1145-9 - PubMed
  22. Stem Cell Reports. 2015 Jun 9;4(6):984-94 - PubMed
  23. Bone. 2015 Nov;80:143-149 - PubMed
  24. Arthritis Res. 2000;2(6):441-5 - PubMed
  25. Gut. 2000 Jan;46 Suppl 1:i1-8 - PubMed
  26. Gerontology. 2016;62(2):128-37 - PubMed
  27. Scand J Gastroenterol. 2009;44(5):571-8 - PubMed
  28. Scientifica (Cairo). 2013;2013:125705 - PubMed
  29. J Clin Invest. 2015 Aug 3;125(8):3269-79 - PubMed
  30. Ann Rheum Dis. 2006 Mar;65(3):398-400 - PubMed
  31. Clin Gastroenterol Hepatol. 2007 Jan;5(1):59-62 - PubMed
  32. J Bone Miner Metab. 2017 Mar;35(2):227-233 - PubMed
  33. Biomed Res Int. 2015;2015:421746 - PubMed
  34. Lancet. 1999 Aug 28;354(9180):744-5 - PubMed
  35. Minerva Ginecol. 2014 Aug;66(4):391-407 - PubMed
  36. Ann Rheum Dis. 2015 Aug;74(8):1631-2 - PubMed
  37. Ann Rheum Dis. 2014 May;73(5):854-60 - PubMed
  38. Am J Pathol. 2007 Feb;170(2):427-35 - PubMed
  39. Biochem Soc Trans. 2014 Dec;42(6):1752-5 - PubMed
  40. Ann Transl Med. 2015 Aug;3(14):189 - PubMed
  41. Reumatismo. 2012 Dec 11;64(5):321-5 - PubMed
  42. Curr Opin Endocrinol Diabetes Obes. 2014 Dec;21(6):461-7 - PubMed
  43. Bone. 2014 Feb;59:127-38 - PubMed
  44. Arthritis Res Ther. 2016 Jun 03;18(1):127 - PubMed
  45. Arthritis Res Ther. 2007;9 Suppl 1:S3 - PubMed
  46. Int J Clin Rheumtol. 2014;9(3):295-309 - PubMed
  47. Nat Rev Endocrinol. 2010 Dec;6(12):698-706 - PubMed
  48. Cell Death Differ. 2017 May;24(5):844-854 - PubMed
  49. J Bone Miner Res. 2002 Dec;17(12):2161-73 - PubMed
  50. Clin Exp Immunol. 1999 Dec;118(3):371-5 - PubMed
  51. Nat Rev Rheumatol. 2012 Nov;8(11):656-64 - PubMed
  52. J Clin Immunol. 2002 Nov;22(6):353-62 - PubMed
  53. Nat Rev Rheumatol. 2017 Jan;13(1):25-40 - PubMed
  54. Endocr Rev. 2008 Jun;29(4):403-40 - PubMed
  55. J Bone Miner Res. 2015 Apr;30(4):630-6 - PubMed
  56. Cancer Cell. 2002 Oct;2(4):251-2 - PubMed
  57. Clin Cases Miner Bone Metab. 2008 Jan;5(1):49-56 - PubMed
  58. Nature. 2004 Apr 15;428(6984):758-63 - PubMed
  59. Clin Exp Immunol. 2001 Aug;125(2):216-21 - PubMed
  60. Ann Rheum Dis. 2016 Apr;75(4):637-9 - PubMed
  61. Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16711-2 - PubMed
  62. Cell Tissue Res. 2010 Jan;339(1):197-211 - PubMed
  63. Lupus. 2014 Oct;23(11):1156-63 - PubMed
  64. J Clin Immunol. 2005 Jan;25(1):1-18 - PubMed
  65. Int Immunol. 2011 Nov;23(11):701-12 - PubMed
  66. J Clin Invest. 2001 Nov;108(10):1417-22 - PubMed
  67. Curr Osteoporos Rep. 2014 Mar;12(1):17-21 - PubMed
  68. Oncotarget. 2015 Jun 20;6(17):14865-73 - PubMed
  69. Rheumatol Int. 2010 Nov;30(12 ):1559-63 - PubMed
  70. Rheumatology (Oxford). 2016 Oct;55(10 ):1791-5 - PubMed
  71. Nat Rev Immunol. 2007 Apr;7(4):292-304 - PubMed
  72. Scand J Gastroenterol. 2005 Oct;40(10):1240-3 - PubMed
  73. Am J Med. 1997 Aug 18;103(2A):12S-17S; discussion 17S-19S - PubMed
  74. Scand J Gastroenterol. 2010 Mar;45(3):305-14 - PubMed
  75. Thromb Haemost. 1994 Apr;71(4):402-15 - PubMed
  76. Curr Opin HIV AIDS. 2014 Jan;9(1):17-26 - PubMed
  77. J Korean Med Sci. 2014 Jan;29(1):2-11 - PubMed
  78. J Clin Invest. 2012 May;122(5):1791-802 - PubMed
  79. Curr Rheumatol Rep. 2013 Oct;15(10):366 - PubMed
  80. Curr Opin Endocrinol Diabetes Obes. 2010 Dec;17(6):540-5 - PubMed
  81. Blood. 2007 May 1;109(9):3839-48 - PubMed
  82. Clin J Am Soc Nephrol. 2008 Nov;3 Suppl 3:S131-9 - PubMed
  83. Proc Am Thorac Soc. 2008 May 1;5(4):478-85 - PubMed
  84. PLoS One. 2014 Sep 12;9(9):e105066 - PubMed
  85. Rheumatol Int. 2013 Feb;33(2):299-307 - PubMed
  86. Cell Death Differ. 2001 Jul;8(7):767-70 - PubMed
  87. Arthritis Res Ther. 2016 Oct 6;18(1):226 - PubMed
  88. Dis Markers. 2013;35(6):727-34 - PubMed
  89. Calcif Tissue Int. 2017 Jul;101(1):17-23 - PubMed
  90. Arthritis Rheumatol. 2014 Apr;66(4):813-21 - PubMed
  91. World J Gastroenterol. 2012 Apr 14;18(14):1622-7 - PubMed
  92. Curr Osteoporos Rep. 2009 Dec;7(4):134-9 - PubMed
  93. Cell. 2002 Jan 11;108(1):17-29 - PubMed
  94. J Bone Miner Res. 2011 Feb;26(2):229-38 - PubMed

Publication Types