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Summers EM, Blickenstaff NR, Coman GC, et al. A pilot study evaluating biomarker development for drug-induced chronic eczematous eruptions of aging individuals. Ann Transl Med. 2017;5(20):393doi: 10.21037/atm.2017.07.16.
Summers, E. M., Blickenstaff, N. R., Coman, G. C., Martins, T. B., Hill, H. R., & Sontheimer, R. D. (2017). A pilot study evaluating biomarker development for drug-induced chronic eczematous eruptions of aging individuals. Annals of translational medicine, 5(20), 393. https://doi.org/10.21037/atm.2017.07.16
Summers, Erika Mae, et al. "A pilot study evaluating biomarker development for drug-induced chronic eczematous eruptions of aging individuals." Annals of translational medicine vol. 5,20 (2017): 393. doi: https://doi.org/10.21037/atm.2017.07.16
Summers EM, Blickenstaff NR, Coman GC, Martins TB, Hill HR, Sontheimer RD. A pilot study evaluating biomarker development for drug-induced chronic eczematous eruptions of aging individuals. Ann Transl Med. 2017 Oct;5(20):393. doi: 10.21037/atm.2017.07.16. PMID: 29152493; PMCID: PMC5673781.
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Ann Transl Med. 2017 Oct;5(20):393. doi: 10.21037/atm.2017.07.16.

A pilot study evaluating biomarker development for drug-induced chronic eczematous eruptions of aging individuals.

Annals of translational medicine

Erika Mae Summers, Nicholas Ray Blickenstaff, Garrett Curtis Coman, Thomas Bernd Martins, Harry Raymond Hill, Richard Dennis Sontheimer

Affiliations

  1. Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT, USA.
  2. ARUP Laboratories, Salt Lake City, UT, USA.

PMID: 29152493 PMCID: PMC5673781 DOI: 10.21037/atm.2017.07.16

Abstract

BACKGROUND: Identifying the drug(s) responsible for drug-induced chronic eczematous eruptions of aging individuals (CEEA) is a clinical challenge in patients on multiple medications. Reliable

METHODS: This was a single center, proof-of-concept pilot study at the University of Utah Hospital, Salt Lake City, Utah. Eight aging study subjects having a history suggestive of chronic eczematous drug eruptions suspected to have resulted from calcium channel blocker (CCB) and/or hydrochlorothiazide (HCTZ) hypersensitivity plus three matched aging control subjects were identified. Drug patch testing for CCB and/or HCTZ,

RESULTS: All study and control subject blood samples tested failed to demonstrate detectable enhanced lymphocyte proliferation or cytokine release to

CONCLUSIONS: This pilot study aimed to correlate

Keywords: Chronic eczematous eruptions in aging individuals; T cell proliferative response; calcium channel blockers (CCBs); cytokine release assay; delayed hypersensitivity reactions (DHR); drug reaction; eczematous drug eruptions; hydrochlorothiazide (HCTZ); lymphocyte proliferation assay

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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