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Wang Y, Chai Y, He X, et al. Intermittent hypoxia simulating obstructive sleep apnea causes pulmonary inflammation and activates the Nrf2/HO-1 pathway. Exp Ther Med. 2017;14(4):3463-3470doi: 10.3892/etm.2017.4971.
Wang, Y., Chai, Y., He, X., Ai, L., Sun, X., Huang, Y., & Li, Y. (2017). Intermittent hypoxia simulating obstructive sleep apnea causes pulmonary inflammation and activates the Nrf2/HO-1 pathway. Experimental and therapeutic medicine, 14(4), 3463-3470. https://doi.org/10.3892/etm.2017.4971
Wang, Yeying, et al. "Intermittent hypoxia simulating obstructive sleep apnea causes pulmonary inflammation and activates the Nrf2/HO-1 pathway." Experimental and therapeutic medicine vol. 14,4 (2017): 3463-3470. doi: https://doi.org/10.3892/etm.2017.4971
Wang Y, Chai Y, He X, Ai L, Sun X, Huang Y, Li Y. Intermittent hypoxia simulating obstructive sleep apnea causes pulmonary inflammation and activates the Nrf2/HO-1 pathway. Exp Ther Med. 2017 Oct;14(4):3463-3470. doi: 10.3892/etm.2017.4971. Epub 2017 Aug 18. PMID: 29042934; PMCID: PMC5639295.
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Exp Ther Med. 2017 Oct;14(4):3463-3470. doi: 10.3892/etm.2017.4971. Epub 2017 Aug 18.

Intermittent hypoxia simulating obstructive sleep apnea causes pulmonary inflammation and activates the Nrf2/HO-1 pathway.

Experimental and therapeutic medicine

Yeying Wang, Yanling Chai, Xiaojie He, Li Ai, Xia Sun, Yiling Huang, Yongxia Li

Affiliations

  1. Department of Respiratory Medicine, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, P.R. China.
  2. Department of Epidemiology and Biostatistics, School of Public Health, Kunming Medical University, Kunming, Yunnan 650500, P.R. China.
  3. Department of Infectious Diseases, Nongken Sanya Hospital, Sanya, Hainan 572000, P.R. China.

PMID: 29042934 PMCID: PMC5639295 DOI: 10.3892/etm.2017.4971

Abstract

Obstructive sleep apnea (OSA) is a disorder with high morbidity in adults. OSA damages multiple organs and tissues, including the cardiovascular and cerebrovascular systems, the metabolism system, the lungs, liver and heart. OSA-induced damage is earliest and greatest to the pulmonary tissue. The present study established a rat OSA model of differing severity by inducing intermittent hypoxia with different concentrations of O

Keywords: inflammation; intermittent hypoxia; nuclear factor erythroid 2-related factor 2; obstructive sleep apnea; oxidative stress

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