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An J, Yan H, Li X, et al. The inhibiting effect of neural stem cells on proliferation and invasion of glioma cells. Oncotarget. 2017;8(44):76949-76960doi: 10.18632/oncotarget.20270.
An, J., Yan, H., Li, X., Tan, R., Chen, X., Zhang, Z., Liu, Y., Zhang, P., Lu, H., & Liu, Y. (2017). The inhibiting effect of neural stem cells on proliferation and invasion of glioma cells. Oncotarget, 8(44), 76949-76960. https://doi.org/10.18632/oncotarget.20270
An, Jing, et al. "The inhibiting effect of neural stem cells on proliferation and invasion of glioma cells." Oncotarget vol. 8,44 (2017): 76949-76960. doi: https://doi.org/10.18632/oncotarget.20270
An J, Yan H, Li X, Tan R, Chen X, Zhang Z, Liu Y, Zhang P, Lu H, Liu Y. The inhibiting effect of neural stem cells on proliferation and invasion of glioma cells. Oncotarget. 2017 Aug 14;8(44):76949-76960. doi: 10.18632/oncotarget.20270. eCollection 2017 Sep 29. PMID: 29100360; PMCID: PMC5652754.
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Oncotarget. 2017 Aug 14;8(44):76949-76960. doi: 10.18632/oncotarget.20270. eCollection 2017 Sep 29.

The inhibiting effect of neural stem cells on proliferation and invasion of glioma cells.

Oncotarget

Jing An, Hanqi Yan, Xingxing Li, Ruolan Tan, Xinlin Chen, Zhichao Zhang, Yingfei Liu, Pengbo Zhang, Haixia Lu, Yong Liu

Affiliations

  1. Institute of Neurobiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, P.R.China.
  2. Department of Human Anatomy and Histoembriology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, P.R.China.
  3. Department of Anesthesia of The Second Affiliated Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710004, P.R.China.

PMID: 29100360 PMCID: PMC5652754 DOI: 10.18632/oncotarget.20270

Abstract

The invasive and infiltrative nature of tumor cells leads to the poor prognosis of glioma. Currently, novel therapeutic means to eliminate the tumor cells without damaging the normal brain tissue are still strongly demanded. Significant attentions had been paid to stem cell-based therapy and neural stem cell (NSC) had been considered as one of the efficient delivery vehicles for targeting therapeutic genes. However, whether the NSCs could directly affect glioma cells remains to be seen. In this study, both rat and human glioma cells (C6 and U251) were co-cultured with normal rat embryonic NSCs directly or in-directly. We found the survival, proliferation, invasion and migration of glioma cells were significantly inhibited, while the differentiation was not affected in the

Keywords: glioma; inhibiting effect; invasion; neural stem cells; proliferation

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare here that there is no conflicts of interest.

References

  1. Cancer Genet. 2012 Dec;205(12):613-21 - PubMed
  2. Anticancer Agents Med Chem. 2010 Feb;10(2):121-30 - PubMed
  3. Nature. 1994 Nov 17;372(6503):263-6 - PubMed
  4. Oncotarget. 2015 Nov 3;6(34):36456-71 - PubMed
  5. Science. 1968 Jul 26;161(3839):370-1 - PubMed
  6. J Biomed Nanotechnol. 2014 Nov;10(11):3219-30 - PubMed
  7. J Int Med Res. 2009 Mar-Apr;37(2):503-10 - PubMed
  8. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11879-83 - PubMed
  9. Cancer Gene Ther. 2005 Jul;12(7):600-7 - PubMed
  10. Oncology. 2005;69(6):503-8 - PubMed
  11. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12846-51 - PubMed
  12. Brain Behav. 2015 Oct 26;5(12 ):e00414 - PubMed
  13. Nat Neurosci. 2017 Apr 25;20(5):637-647 - PubMed
  14. Science. 2000 Feb 25;287(5457):1433-8 - PubMed
  15. Arch Neurol. 2008 Apr;65(4):452-6 - PubMed
  16. Exp Hematol. 2008 Jun;36(6):733-41 - PubMed
  17. Oncotarget. 2015 Apr 20;6(11):8788-806 - PubMed
  18. Cancer Res. 2007 Apr 15;67(8):3691-7 - PubMed
  19. Oncotarget. 2015 Nov 10;6(35):37300-15 - PubMed
  20. Nat Med. 2012 Aug;18(8):1232-8 - PubMed
  21. Curr Opin Mol Ther. 2010 Oct;12(5):546-52 - PubMed
  22. Cancer Gene Ther. 2003 May;10(5):396-402 - PubMed
  23. Appl Microbiol Biotechnol. 2014 Sep;98(17):7359-64 - PubMed
  24. Sci Transl Med. 2013 May 8;5(184):184ra59 - PubMed
  25. Glia. 2013 Feb;61(2):225-39 - PubMed
  26. Oncol Lett. 2016 Jan;11(1):9-15 - PubMed
  27. Neurochem Int. 2017 Jun;106:94-100 - PubMed
  28. Stem Cells Dev. 2013 Jun 1;22(11):1709-16 - PubMed
  29. Gene Ther. 2008 May;15(10):739-52 - PubMed
  30. Tumour Biol. 2016 Jul;37(7):9243-8 - PubMed
  31. Eur J Cancer. 2006 Jun;42(9):1298-308 - PubMed
  32. J Neurosci. 2005 Mar 9;25(10):2637-46 - PubMed
  33. Curr Opin Organ Transplant. 2011 Feb;16(1):90-5 - PubMed
  34. Oncotarget. 2016 Apr 5;7(14 ):17920-31 - PubMed
  35. J Natl Compr Canc Netw. 2014 Nov;12(11):1517-23 - PubMed
  36. N Engl J Med. 2005 Mar 10;352(10 ):987-96 - PubMed

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