Display options
Cite
Weiss R, Santoro N, Giannini C, et al. Prediabetes in youth - mechanisms and biomarkers. Lancet Child Adolesc Health. 2017;1(3):240-248doi: 10.1016/S2352-4642(17)30044-5.
Weiss, R., Santoro, N., Giannini, C., Galderisi, A., Umano, G. R., & Caprio, S. (2017). Prediabetes in youth - mechanisms and biomarkers. The Lancet. Child & adolescent health, 1(3), 240-248. https://doi.org/10.1016/S2352-4642(17)30044-5
Weiss, Ram, et al. "Prediabetes in youth - mechanisms and biomarkers." The Lancet. Child & adolescent health vol. 1,3 (2017): 240-248. doi: https://doi.org/10.1016/S2352-4642(17)30044-5
Weiss R, Santoro N, Giannini C, Galderisi A, Umano GR, Caprio S. Prediabetes in youth - mechanisms and biomarkers. Lancet Child Adolesc Health. 2017 Nov;1(3):240-248. doi: 10.1016/S2352-4642(17)30044-5. Epub 2017 Sep 26. PMID: 29075659; PMCID: PMC5652329.
Copy Download .nbib Format: NLM
Share it on

Lancet Child Adolesc Health. 2017 Nov;1(3):240-248. doi: 10.1016/S2352-4642(17)30044-5. Epub 2017 Sep 26.

Prediabetes in youth - mechanisms and biomarkers.

The Lancet. Child & adolescent health

Ram Weiss, Nicola Santoro, Cosimo Giannini, Alfonso Galderisi, Giuseppina Rosaria Umano, Sonia Caprio

Affiliations

  1. Department of Pediatrics, Ruth Rappaport Childrens' Hospital, Rambam Medical Center, Haifa, Israel.
  2. Department of Pediatrics, Division of Pediatric Endocrinology, , Yale University School of Medicine, New Haven, CT 06520.
  3. Department of Women and Children's Health, University of Padova, Padova, Italy.

PMID: 29075659 PMCID: PMC5652329 DOI: 10.1016/S2352-4642(17)30044-5

Abstract

Obesity has been estimated to decrease life expectancy by as little as 0.8 to as much as 7 years being the second leading cause of preventable death in the United States after smoking. Along with the increase in the prevalence of obesity, there has been a dramatic rise of the prevalence of prediabetes and type 2 diabetes among adolescents. Despite that, very little is known about the pathogenesis of these conditions in pediatrics and about how we could detect prediabetes in an early stage in order to prevent full blown diabetes. In this review we summarize the current knowledge on the pathophysiology of prediabetes and type 2 diabetes in adolescents and describe how biomarkers of beta-cell function might help identifying those individuals who are prone to progress from normal glucose tolerance towards prediabetes and overt type 2 diabetes. To better understand and fight this disease, we will need to explore and develop novel therapeutic strategies and individuate more sensitive and specific biomarkers that can allow an earlier detection of the disease.

Keywords: Disposition Index; Prediabetes; TCF7L2

Conflict of interest statement

The authors declared no conflicts of interest

References

  1. Arch Dis Child Fetal Neonatal Ed. 2013 Mar;98(2):F136-40 - PubMed
  2. J Adolesc Health. 2006 May;38(5):591-8 - PubMed
  3. Panminerva Med. 2013 Sep;55(3):269-75 - PubMed
  4. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12587-94 - PubMed
  5. Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15430-5 - PubMed
  6. Diabetes Care. 2014;37(3):780-8 - PubMed
  7. Diabetologia. 2007 Jan;50(1):5-7 - PubMed
  8. Int J Obes (Lond). 2014 Jan;38(1):40-5 - PubMed
  9. N Engl J Med. 2010 Mar 4;362(9):800-11 - PubMed
  10. Endocr Pract. 2016 Feb;22(2):220-30 - PubMed
  11. Science. 2007 Jun 1;316(5829):1336-41 - PubMed
  12. N Engl J Med. 2017 Apr 13;376(15):1419-1429 - PubMed
  13. Diabetologia. 1997 Feb;40(2):205-11 - PubMed
  14. J Clin Endocrinol Metab. 2005 Jun;90(6):3731-7 - PubMed
  15. J Pediatr. 2010 Aug;157(2):198-202.e1 - PubMed
  16. Lancet. 2011 Jul 2;378(9785):31-40 - PubMed
  17. Diabetes Care. 2011 Jun;34(6):1306-11 - PubMed
  18. Diabetes Res Clin Pract. 2007 Dec;78(3):305-12 - PubMed
  19. Diabetes Care. 2009 Mar;32(3):456-61 - PubMed
  20. Obesity (Silver Spring). 2008 Aug;16(8):1901-7 - PubMed
  21. Diabetes Care. 2010 Aug;33(8):1817-22 - PubMed
  22. Pediatrics. 2005 Nov;116(5):1122-6 - PubMed
  23. Diabetes. 2002 Feb;51 Suppl 1:S227-33 - PubMed
  24. Nutr Diabetes. 2016 Aug 22;6(8):e227 - PubMed
  25. BMC Public Health. 2015 Dec 24;15:1298 - PubMed
  26. J Diabetes Sci Technol. 2012 Jul 01;6(4):797-801 - PubMed
  27. Diabetes Care. 2005 May;28(5):1051-6 - PubMed
  28. J Clin Endocrinol Metab. 2013 Sep;98(9):3748-54 - PubMed
  29. Eur J Pediatr. 2011 May;170(5):589-97 - PubMed
  30. Diabetes Care. 2016 Jun;39(6):e74-5 - PubMed
  31. Pediatr Diabetes. 2014 May;15(3):220-8 - PubMed
  32. Diabetes Care. 2006 Jan;29(1):51-6 - PubMed
  33. Diabetes. 2013 Oct;62(10):3561-9 - PubMed
  34. Diabetes Obes Metab. 2016 May;18(5):500-7 - PubMed
  35. Diabetes Technol Ther. 2016 Jan;18(1):22-8 - PubMed
  36. J Clin Endocrinol Metab. 2004 Mar;89(3):1096-101 - PubMed
  37. Diabetes. 2002 Jun;51(6):1681-9 - PubMed
  38. Diabetes. 2002 Feb;51 Suppl 1:S109-16 - PubMed
  39. N Engl J Med. 2010 Jul 22;363(4):311-20 - PubMed
  40. Diabetes Care. 2006 Feb;29(2):212-7 - PubMed
  41. Nat Rev Genet. 2016 Sep;17 (9):535-49 - PubMed
  42. BMC Pediatr. 2015 Mar 20;15:24 - PubMed
  43. Diabetes. 2012 Mar;61(3):606-14 - PubMed
  44. J Diabetes Sci Technol. 2013 Nov 01;7(6):1470-83 - PubMed
  45. J Clin Endocrinol Metab. 2003 May;88(5):2014-8 - PubMed
  46. Mayo Clin Proc. 2014 Jun;89(6):806-16 - PubMed
  47. Pediatr Diabetes. 2007 Oct;8(5):286-98 - PubMed
  48. Endocr J. 2016;63(2):119-26 - PubMed
  49. Diabetes Care. 2017 Aug;40(8):1082-1089 - PubMed
  50. Diabetes Care. 2007 Jul;30(7):1845-50 - PubMed
  51. Diabetes Care. 2011 Jan;34 Suppl 1:S62-9 - PubMed
  52. Hepatology. 2009 Jun;49(6):1896-903 - PubMed
  53. J Clin Endocrinol Metab. 2012 Aug;97(8):E1483-91 - PubMed
  54. Sci Signal. 2011 Feb 01;4(158):ra6 - PubMed
  55. J Clin Invest. 2016 Jan;126(1):12-22 - PubMed
  56. Diabetes Care. 2014 Feb;37(2):475-82 - PubMed
  57. Pediatr Diabetes. 2010 Feb;11(1):47-54 - PubMed
  58. Diabetes. 2011 Jun;60(6):1805-12 - PubMed
  59. Diabetes Technol Ther. 2016 Mar;18(3):127-35 - PubMed
  60. Indian Pediatr. 2011 Apr;48(4):295-9 - PubMed
  61. Diabetes Care. 2005 Apr;28(4):902-9 - PubMed
  62. Diabetologia. 2006 Mar;49(3):571-9 - PubMed
  63. Diabetes Care. 2013 Jan;36(1):130-6 - PubMed
  64. Am J Physiol. 1979 Jun;236(6):E667-77 - PubMed
  65. Obesity (Silver Spring). 2009 Jul;17(7):1318-25 - PubMed
  66. Arch Pediatr Adolesc Med. 2006 May;160(5):523-8 - PubMed
  67. Ann N Y Acad Sci. 2008 Dec;1150:1-13 - PubMed
  68. J Clin Endocrinol Metab. 2008 May;93(5):1767-73 - PubMed
  69. Diabet Med. 2009 Dec;26(12):1198-203 - PubMed
  70. Pediatrics. 2003 Apr;111(4 Pt 2):e497-503 - PubMed
  71. Nutr Metab Cardiovasc Dis. 2006 May;16(4):279-84 - PubMed
  72. Nat Genet. 2008 May;40(5):638-45 - PubMed
  73. J Pediatr. 2009 Sep;155(3):369-73 - PubMed
  74. Diabetologia. 2015 Apr;58(4):687-90 - PubMed
  75. Nat Genet. 2012 Sep;44(9):981-90 - PubMed
  76. Ethn Health. 2015 ;20(4):365-375 - PubMed
  77. J Clin Invest. 2006 Jul;116(7):1784-92 - PubMed
  78. N Engl J Med. 2002 Mar 14;346(11):802-10 - PubMed
  79. Nat Genet. 2010 Feb;42(2):105-16 - PubMed
  80. J Matern Fetal Neonatal Med. 2012 Jul;25(7):1122-6 - PubMed
  81. Diabetes. 2006 Oct;55(10):2890-5 - PubMed
  82. Diabetes Care. 2012 Dec;35(12):2515-20 - PubMed
  83. Diabetes. 2001 Nov;50(11):2444-50 - PubMed

Publication Types

Grant support