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Schulze RJ, Drižytė K, Casey CA, et al. Hepatic Lipophagy: New Insights into Autophagic Catabolism of Lipid Droplets in the Liver. Hepatol Commun. 2017;1(5):359-369doi: 10.1002/hep4.1056.
Schulze, R. J., Drižytė, K., Casey, C. A., & McNiven, M. A. (2017). Hepatic Lipophagy: New Insights into Autophagic Catabolism of Lipid Droplets in the Liver. Hepatology communications, 1(5), 359-369. https://doi.org/10.1002/hep4.1056
Schulze, Ryan J, et al. "Hepatic Lipophagy: New Insights into Autophagic Catabolism of Lipid Droplets in the Liver." Hepatology communications vol. 1,5 (2017): 359-369. doi: https://doi.org/10.1002/hep4.1056
Schulze RJ, Drižytė K, Casey CA, McNiven MA. Hepatic Lipophagy: New Insights into Autophagic Catabolism of Lipid Droplets in the Liver. Hepatol Commun. 2017 Jul;1(5):359-369. doi: 10.1002/hep4.1056. Epub 2017 Jun 09. PMID: 29109982; PMCID: PMC5669271.
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Hepatol Commun. 2017 Jul;1(5):359-369. doi: 10.1002/hep4.1056. Epub 2017 Jun 09.

Hepatic Lipophagy: New Insights into Autophagic Catabolism of Lipid Droplets in the Liver.

Hepatology communications

Ryan J Schulze, Kristina Drižytė, Carol A Casey, Mark A McNiven

Affiliations

  1. Department of Biochemistry and Molecular Biology and the Center for Digestive Diseases, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.
  2. Biochemistry and Molecular Biology Program, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA.
  3. Department of Internal Medicine, University of Nebraska Medical Center, 988090 Nebraska Medical Center, Omaha, NE, 68198, USA.
  4. Research Service, VA Nebraska-Western Iowa Health Care System (VA NWIHCS), Omaha, NE, 68198, USA.

PMID: 29109982 PMCID: PMC5669271 DOI: 10.1002/hep4.1056

Abstract

The liver is a central fat-storage organ, making it especially susceptible to steatosis as well as subsequent inflammation and cirrhosis. The mechanisms by which the liver mobilizes stored lipid for energy production, however, remain incompletely defined. The catabolic process of autophagy, a well-known process of bulk cytoplasmic recycling and cellular self-regeneration, is a central regulator of lipid metabolism in the liver. In the past decade, numerous studies have examined a selective form of autophagy that specifically targets a unique neutral lipid storage organelle, the lipid droplet, to better understand the function for this process in hepatocellular fatty acid metabolism. In the liver (and other oxidative tissues), this specialized pathway, lipophagy, likely plays as important of a role in lipid turnover as conventional lipase-driven lipolysis. In this review, we will highlight several recent studies that have contributed to our understanding about the regulation and effects of hepatic lipophagy.

Keywords: Lipid droplet; autophagy; hepatocyte; lipolysis; lysosome

Conflict of interest statement

AUTHOR STATEMENT All authors have no conflict of interest to declare. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Inst

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