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Oellers P, Laíns I, Mach S, et al. Novel grid combined with peripheral distortion correction for ultra-widefield image grading of age-related macular degeneration. Clin Ophthalmol. 2017;11:1967-1974doi: 10.2147/OPTH.S143246.
Oellers, P., Laíns, I., Mach, S., Garas, S., Kim, I. K., Vavvas, D. G., Miller, J. W., Husain, D., & Miller, J. B. (2017). Novel grid combined with peripheral distortion correction for ultra-widefield image grading of age-related macular degeneration. Clinical ophthalmology (Auckland, N.Z.), 111967-1974. https://doi.org/10.2147/OPTH.S143246
Oellers, Patrick, et al. "Novel grid combined with peripheral distortion correction for ultra-widefield image grading of age-related macular degeneration." Clinical ophthalmology (Auckland, N.Z.) vol. 11 (2017): 1967-1974. doi: https://doi.org/10.2147/OPTH.S143246
Oellers P, Laíns I, Mach S, Garas S, Kim IK, Vavvas DG, Miller JW, Husain D, Miller JB. Novel grid combined with peripheral distortion correction for ultra-widefield image grading of age-related macular degeneration. Clin Ophthalmol. 2017 Nov 08;11:1967-1974. doi: 10.2147/OPTH.S143246. eCollection 2017. PMID: 29184386; PMCID: PMC5687493.
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Clin Ophthalmol. 2017 Nov 08;11:1967-1974. doi: 10.2147/OPTH.S143246. eCollection 2017.

Novel grid combined with peripheral distortion correction for ultra-widefield image grading of age-related macular degeneration.

Clinical ophthalmology (Auckland, N.Z.)

Patrick Oellers, Inês Laíns, Steven Mach, Shady Garas, Ivana K Kim, Demetrios G Vavvas, Joan W Miller, Deeba Husain, John B Miller

Affiliations

  1. Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
  2. Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

PMID: 29184386 PMCID: PMC5687493 DOI: 10.2147/OPTH.S143246

Abstract

PURPOSE: Eyes with age-related macular degeneration (AMD) often harbor pathological changes in the retinal periphery and perimacular region. These extramacular changes have not been well classified, but may be phenotypically and functionally relevant. The purpose of this study was to demonstrate a novel grid to systematically study peripheral retinal abnormalities in AMD using geometric distortion-corrected ultra-widefield (UWF) imaging.

METHODS: This is a cross-sectional observational case series. Consecutive patients with AMD without any other coexisting vitreoretinal disease and control patients over age 50 without AMD or any other vitreoretinal disease were imaged using Optos 200 Tx. Captured 200° UWF images were corrected for peripheral geometric distortion using Optos transformation software. A newly developed grid to study perimacular and peripheral abnormalities in AMD was then projected onto the images.

RESULTS: Peripheral and perimacular changes such as drusen, retinal pigment epithelium changes and atrophy were found in patients with AMD. The presented grid in conjunction with geometric distortion-corrected UWF images allowed for systematic study of these peripheral changes in AMD.

CONCLUSION: We present a novel grid to study peripheral and posterior pole changes in AMD. The grid is unique in that it adds a perimacular zone, which may be important in characterizing certain phenotypes in AMD. Our UWF images were corrected for geometric peripheral distortion to accurately reflect the anatomical dimensions of the retina. This grid offers a reliable and reproducible foundation for the exploration of peripheral retinal pathology associated with AMD.

Keywords: autofluorescence; drusen; grid; macular degeneration; periphery; retinal pigment epithelium changes; ultra-widefield

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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