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Uryu K, Nishimura R, Kataoka K, et al. Identification of the genetic and clinical characteristics of neuroblastomas using genome-wide analysis. Oncotarget. 2017;8(64):107513-107529doi: 10.18632/oncotarget.22495.
Uryu, K., Nishimura, R., Kataoka, K., Sato, Y., Nakazawa, A., Suzuki, H., Yoshida, K., Seki, M., Hiwatari, M., Isobe, T., Shiraishi, Y., Chiba, K., Tanaka, H., Miyano, S., Koh, K., Hanada, R., Oka, A., Hayashi, Y., Ohira, M., Kamijo, T., Nagase, H., Takimoto, T., Tajiri, T., Nakagawara, A., Ogawa, S., & Takita, J. (2017). Identification of the genetic and clinical characteristics of neuroblastomas using genome-wide analysis. Oncotarget, 8(64), 107513-107529. https://doi.org/10.18632/oncotarget.22495
Uryu, Kumiko, et al. "Identification of the genetic and clinical characteristics of neuroblastomas using genome-wide analysis." Oncotarget vol. 8,64 (2017): 107513-107529. doi: https://doi.org/10.18632/oncotarget.22495
Uryu K, Nishimura R, Kataoka K, Sato Y, Nakazawa A, Suzuki H, Yoshida K, Seki M, Hiwatari M, Isobe T, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Koh K, Hanada R, Oka A, Hayashi Y, Ohira M, Kamijo T, Nagase H, Takimoto T, Tajiri T, Nakagawara A, Ogawa S, Takita J. Identification of the genetic and clinical characteristics of neuroblastomas using genome-wide analysis. Oncotarget. 2017 Nov 18;8(64):107513-107529. doi: 10.18632/oncotarget.22495. eCollection 2017 Dec 08. PMID: 29296183; PMCID: PMC5746085.
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Oncotarget. 2017 Nov 18;8(64):107513-107529. doi: 10.18632/oncotarget.22495. eCollection 2017 Dec 08.

Identification of the genetic and clinical characteristics of neuroblastomas using genome-wide analysis.

Oncotarget

Kumiko Uryu, Riki Nishimura, Keisuke Kataoka, Yusuke Sato, Atsuko Nakazawa, Hiromichi Suzuki, Kenichi Yoshida, Masafumi Seki, Mitsuteru Hiwatari, Tomoya Isobe, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Katsuyoshi Koh, Ryoji Hanada, Akira Oka, Yasuhide Hayashi, Miki Ohira, Takehiko Kamijo, Hiroki Nagase, Tetsuya Takimoto, Tatsuro Tajiri, Akira Nakagawara, Seishi Ogawa, Junko Takita

Affiliations

  1. Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  2. Department of Pathology and Tumor Biology, Graduate School of Medicine, University of Kyoto, Kyoto, Japan.
  3. Department of Pathology, National Center for Child Health and Development, Tokyo, Japan.
  4. Cell Therapy and Transplantation Medicine, The University of Tokyo, Japan.
  5. Laboratory of DNA Information Analysis, Human Genome Centre, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  6. Saitama Children's Medical Center, Saitama, Japan.
  7. Gunma Red Cross Blood Center, Japanese Red Cross Society, Gunma, Japan.
  8. Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan.
  9. Laboratory of Cancer Genetics, Chiba Cancer Research Institute, Chiba, Japan.
  10. National Center for Child Health and Development, Tokyo, Japan.
  11. Japan Neuroblastoma Study Group.
  12. Saga Medical Center Koseikan, Saga, Japan.

PMID: 29296183 PMCID: PMC5746085 DOI: 10.18632/oncotarget.22495

Abstract

To provide better insight into the genetic signatures of neuroblastomas, we analyzed 500 neuroblastomas (included specimens from JNBSG) using targeted-deep sequencing for 10 neuroblastoma-related genes and SNP arrays analysis. ALK expression was evaluated using immunohistochemical analysis in 259 samples. Based on genetic alterations, the following 6 subgroups were identified: groups A (

Keywords: ALK; ALK immunohistochemistry staining; Japan neuroblastoma study group (JNBSG); copy number variants; target amplicon deep sequencing

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no potential conflicts of interest.

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