Display options
Cite
de Matos SB, Meyer R, Lima FWM. Cytomegalovirus Infection after Renal Transplantation: Occurrence, Clinical Features, and the Cutoff for Antigenemia in a University Hospital in Brazil. Infect Chemother. 2017;49(4):255-261doi: 10.3947/ic.2017.49.4.255.
de Matos, S. B., Meyer, R., & Lima, F. W. M. (2017). Cytomegalovirus Infection after Renal Transplantation: Occurrence, Clinical Features, and the Cutoff for Antigenemia in a University Hospital in Brazil. Infection & chemotherapy, 49(4), 255-261. https://doi.org/10.3947/ic.2017.49.4.255
de Matos, Sócrates Bezerra, et al. "Cytomegalovirus Infection after Renal Transplantation: Occurrence, Clinical Features, and the Cutoff for Antigenemia in a University Hospital in Brazil." Infection & chemotherapy vol. 49,4 (2017): 255-261. doi: https://doi.org/10.3947/ic.2017.49.4.255
de Matos SB, Meyer R, Lima FWM. Cytomegalovirus Infection after Renal Transplantation: Occurrence, Clinical Features, and the Cutoff for Antigenemia in a University Hospital in Brazil. Infect Chemother. 2017 Dec;49(4):255-261. doi: 10.3947/ic.2017.49.4.255. PMID: 29299892; PMCID: PMC5754335.
Copy Download .nbib Format: NLM
Share it on

Infect Chemother. 2017 Dec;49(4):255-261. doi: 10.3947/ic.2017.49.4.255.

Cytomegalovirus Infection after Renal Transplantation: Occurrence, Clinical Features, and the Cutoff for Antigenemia in a University Hospital in Brazil.

Infection & chemotherapy

Sócrates Bezerra de Matos, Roberto Meyer, Fernanda Washington de Mendonça Lima

Affiliations

  1. Immunology Service for Infectious Diseases, Faculty of Pharmacy, Federal University of Bahia, Salvador, BA, Brazil. [email protected].
  2. Health Sciences Institute, Federal University of Bahia, Salvador, BA, Brazil.
  3. Immunology Service for Infectious Diseases, Faculty of Pharmacy, Federal University of Bahia, Salvador, BA, Brazil. [email protected].

PMID: 29299892 PMCID: PMC5754335 DOI: 10.3947/ic.2017.49.4.255

Abstract

BACKGROUND: Cytomegalovirus (CMV) is the main infectious agent causative of morbidity and mortality in transplant recipients. This study aimed to describe the occurrence and clinical features of CMV infection, and the optimum antigenemia assay cutoff associated with symptomatic infection.

MATERIALS AND METHODS: This was a cohort study that investigated 87 patients undergoing renal transplantation. The patients were monitored with the CMV antigenemia assay performed weekly for the first 3 months post-transplantation and subsequently, when CMV infection was suspected clinically.

RESULTS: CMV infection was observed in 63.2% (55/87) of the recipients during the follow-up. Of the 65 episodes observed, 75% (49/65) occurred until 100 days after transplantation (D+100) and 25% (16/65) after D+100 with a median of 60 days. CMV infection was associated with age of the transplant recipients (P = 0.001) and use of deceased donor organ (P = 0.009). There were asymptomatic (34%) and symptomatic (66%) episodes of CMV infection, in which diarrhea was the most common symptom (22.6%), followed by elevated creatinine levels (14.5%), fever (12.9%) and leukopenia (10.5%). The optimum cutoff point associated with symptomatic infection was 5 positive cells/200,000 leukocytes (area under the curve = 0.87, positive predictive value = 88% and negative predictive value= 71%).

CONCLUSIONS: The high occurrence and the risk factors for CMV infection such as the age of recipients, the number of positive cells in the antigenemia assay, and use of a deceased donor organ should be considered for appropriate monitoring and management of kidney recipients during the post-transplant period.

Copyright © 2017 by The Korean Society of Infectious Diseases and Korean Society for Chemotherapy

Keywords: Cytomegalovirus; Diagnosis; Kidney transplantation; Risk factors; Signs and symptoms

Conflict of interest statement

No conflicts of interest.

References

  1. Transplantation. 2014 Mar 15;97(5):569-75 - PubMed
  2. Transplantation. 2011 Dec 15;92 (11):1181-7 - PubMed
  3. Clin Transplant. 2010 Jul-Aug;24(4):572-7 - PubMed
  4. Nephrology (Carlton). 2011 Nov;16(8):683-7 - PubMed
  5. Transplant Proc. 2012 Apr;44(3):694-700 - PubMed
  6. J Clin Virol. 2011 Aug;51(4):223-8 - PubMed
  7. Transplant Proc. 2012 Nov;44(9):2715-7 - PubMed
  8. Clin Microbiol Rev. 2013 Oct;26(4):703-27 - PubMed
  9. Transplant Proc. 2013 Jan-Feb;45(1):182-4 - PubMed
  10. J Clin Virol. 2008 Feb;41(2):92-5 - PubMed
  11. Infect Chemother. 2013 Sep;45(3):260-71 - PubMed
  12. Clin Infect Dis. 2017 Jul 1;65(1):57-63 - PubMed
  13. Am J Kidney Dis. 2011 Jul;58(1):118-26 - PubMed
  14. BMC Infect Dis. 2017 Jul 17;17 (1):501 - PubMed
  15. Pediatr Transplant. 2013 Sep;17(6):499-509 - PubMed
  16. Transplant Proc. 2010 Apr;42(3):804-10 - PubMed
  17. J Med Virol. 2013 May;85(5):893-8 - PubMed
  18. Transplant Proc. 2005 Jul-Aug;37(6):2781-3 - PubMed
  19. Clin Infect Dis. 2017 Jan 1;64(1):87-91 - PubMed
  20. Transplantation. 2010 Apr 15;89(7):779-95 - PubMed

Publication Types