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Ni H, Whittaker DG, Wang W, et al. Synergistic Anti-arrhythmic Effects in Human Atria with Combined Use of Sodium Blockers and Acacetin. Front Physiol. 2017;8:946doi: 10.3389/fphys.2017.00946.
Ni, H., Whittaker, D. G., Wang, W., Giles, W. R., Narayan, S. M., & Zhang, H. (2017). Synergistic Anti-arrhythmic Effects in Human Atria with Combined Use of Sodium Blockers and Acacetin. Frontiers in physiology, 8946. https://doi.org/10.3389/fphys.2017.00946
Ni, Haibo, et al. "Synergistic Anti-arrhythmic Effects in Human Atria with Combined Use of Sodium Blockers and Acacetin." Frontiers in physiology vol. 8 (2017): 946. doi: https://doi.org/10.3389/fphys.2017.00946
Ni H, Whittaker DG, Wang W, Giles WR, Narayan SM, Zhang H. Synergistic Anti-arrhythmic Effects in Human Atria with Combined Use of Sodium Blockers and Acacetin. Front Physiol. 2017 Nov 23;8:946. doi: 10.3389/fphys.2017.00946. eCollection 2017. PMID: 29218016; PMCID: PMC5703742.
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Front Physiol. 2017 Nov 23;8:946. doi: 10.3389/fphys.2017.00946. eCollection 2017.

Synergistic Anti-arrhythmic Effects in Human Atria with Combined Use of Sodium Blockers and Acacetin.

Frontiers in physiology

Haibo Ni, Dominic G Whittaker, Wei Wang, Wayne R Giles, Sanjiv M Narayan, Henggui Zhang

Affiliations

  1. Biological Physics Group, University of Manchester, Manchester, United Kingdom.
  2. Space Institute of Southern China, Shenzhen, China.
  3. Key Laboratory of Medical Electrophysiology, Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease/Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China.
  4. Faculties of Kinesiology and Medicine, University of Calgary, Calgary, AB, Canada.
  5. Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States.
  6. School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China.

PMID: 29218016 PMCID: PMC5703742 DOI: 10.3389/fphys.2017.00946

Abstract

Atrial fibrillation (AF) is the most common cardiac arrhythmia. Developing effective and safe anti-AF drugs remains an unmet challenge. Simultaneous block of both atrial-specific ultra-rapid delayed rectifier potassium (K

Keywords: atrial fibrillation; atrial-selective block; multiscale simulation; sodium and potassium current block; synergistic antiarrhythmic effect

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