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Wang D, Zhang P, Zhang M. Predictors for advanced liver fibrosis in chronic hepatitis B virus infection with persistently normal or mildly elevated alanine aminotransferase. Exp Ther Med. 2017;14(6):5363-5370doi: 10.3892/etm.2017.5219.
Wang, D., Zhang, P., & Zhang, M. (2017). Predictors for advanced liver fibrosis in chronic hepatitis B virus infection with persistently normal or mildly elevated alanine aminotransferase. Experimental and therapeutic medicine, 14(6), 5363-5370. https://doi.org/10.3892/etm.2017.5219
Wang, Dexin, et al. "Predictors for advanced liver fibrosis in chronic hepatitis B virus infection with persistently normal or mildly elevated alanine aminotransferase." Experimental and therapeutic medicine vol. 14,6 (2017): 5363-5370. doi: https://doi.org/10.3892/etm.2017.5219
Wang D, Zhang P, Zhang M. Predictors for advanced liver fibrosis in chronic hepatitis B virus infection with persistently normal or mildly elevated alanine aminotransferase. Exp Ther Med. 2017 Dec;14(6):5363-5370. doi: 10.3892/etm.2017.5219. Epub 2017 Sep 29. PMID: 29285064; PMCID: PMC5740558.
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Exp Ther Med. 2017 Dec;14(6):5363-5370. doi: 10.3892/etm.2017.5219. Epub 2017 Sep 29.

Predictors for advanced liver fibrosis in chronic hepatitis B virus infection with persistently normal or mildly elevated alanine aminotransferase.

Experimental and therapeutic medicine

Dexin Wang, Ping Zhang, Min Zhang

Affiliations

  1. Department of Medicine, The Sixth People's Hospital of Qingdao, Qingdao, Shandong 266033, P.R. China.

PMID: 29285064 PMCID: PMC5740558 DOI: 10.3892/etm.2017.5219

Abstract

The aim of the present study was to evaluate the predictors for advanced liver fibrosis in patients with chronic hepatitis B virus (HBV) infection with persistently normal alanine aminotransferase (PNALT), or persistently or intermittently mildly elevated ALT (PIEALT). A total of 305 patients were included in the present study. Liver biopsies were evaluated using the METAVIR scoring system. Liver stiffness (LS) was measured using Fibroscan. Multivariate logistic regression and the area under the receiver operating characteristic curve (AUROC) were used to examine the diagnostic value of the predictors for advanced liver fibrosis. HBV DNA viral load in the PNALT group was significantly lower compared with the PIEALT group (4.57±1.68 vs. 5.71±1.69 log

Keywords: Fibroscan; METAVIR scoring system; alanine aminotransferase; hepatitis B; liver fibrosis; upper limit of normal

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