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Moos WH, Faller DV, Glavas IP, et al. Epigenetic Treatment of Neurodegenerative Ophthalmic Disorders: An Eye Toward the Future. Biores Open Access. 2017;6(1):169-181doi: 10.1089/biores.2017.0036.
Moos, W. H., Faller, D. V., Glavas, I. P., Harpp, D. N., Irwin, M. H., Kanara, I., Pinkert, C. A., Powers, W. R., Steliou, K., Vavvas, D. G., & Kodukula, K. (2017). Epigenetic Treatment of Neurodegenerative Ophthalmic Disorders: An Eye Toward the Future. BioResearch open access, 6(1), 169-181. https://doi.org/10.1089/biores.2017.0036
Moos, Walter H, et al. "Epigenetic Treatment of Neurodegenerative Ophthalmic Disorders: An Eye Toward the Future." BioResearch open access vol. 6,1 (2017): 169-181. doi: https://doi.org/10.1089/biores.2017.0036
Moos WH, Faller DV, Glavas IP, Harpp DN, Irwin MH, Kanara I, Pinkert CA, Powers WR, Steliou K, Vavvas DG, Kodukula K. Epigenetic Treatment of Neurodegenerative Ophthalmic Disorders: An Eye Toward the Future. Biores Open Access. 2017 Dec 01;6(1):169-181. doi: 10.1089/biores.2017.0036. eCollection 2017. PMID: 29291141; PMCID: PMC5747116.
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Biores Open Access. 2017 Dec 01;6(1):169-181. doi: 10.1089/biores.2017.0036. eCollection 2017.

Epigenetic Treatment of Neurodegenerative Ophthalmic Disorders: An Eye Toward the Future.

BioResearch open access

Walter H Moos, Douglas V Faller, Ioannis P Glavas, David N Harpp, Michael H Irwin, Iphigenia Kanara, Carl A Pinkert, Whitney R Powers, Kosta Steliou, Demetrios G Vavvas, Krishna Kodukula

Affiliations

  1. Department of Pharmaceutical Chemistry, School of Pharmacy, University of California San Francisco, San Francisco, California.
  2. ShangPharma Innovation, Inc., South San Francisco, California.
  3. Department of Medicine, Boston University School of Medicine, Boston, Massachusetts.
  4. Cancer Research Center, Boston University School of Medicine, Boston, Massachusetts.
  5. Department of Ophthalmology, New York University School of Medicine, New York, New York.
  6. Department of Chemistry, McGill University, Montreal, QC, Canada.
  7. Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama.
  8. Embassy of Greece in Moscow, Moscow, Russia.
  9. Department of Biological Sciences, College of Arts and Sciences, The University of Alabama, Tuscaloosa, Alabama.
  10. Department of Health Sciences, Boston University, Boston, Massachusetts.
  11. Department of Anatomy, Boston University School of Medicine, Boston, Massachusetts.
  12. PhenoMatriX, Inc., Natick, Massachusetts.
  13. Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.
  14. Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
  15. Bridgewater College, Bridgewater, Virginia.

PMID: 29291141 PMCID: PMC5747116 DOI: 10.1089/biores.2017.0036

Abstract

Eye disease is one of the primary medical conditions that requires attention and therapeutic intervention in ageing populations worldwide. Further, the global burden of diabetes and obesity, along with heart disease, all lead to secondary manifestations of ophthalmic distress. Therefore, there is increased interest in developing innovative new approaches that target various mechanisms and sequelae driving conditions that result in adverse vision. The research challenge is even greater given that the terrain of eye diseases is difficult to landscape into a single therapeutic theme. This report addresses the burden of eye disease due to mitochondrial dysfunction, including antioxidant, autophagic, epigenetic, mitophagic, and other cellular processes that modulate the biomedical end result. In this light, we single out lipoic acid as a potent known natural activator of these pathways, along with alternative and potentially more effective conjugates, which together harness the necessary potency, specificity, and biodistribution parameters required for improved therapeutic outcomes.

Keywords: antioxidant; carnitine; lipoic acid; macular degeneration; mitochondria; retina

Conflict of interest statement

K.S. owns shares in PhenoMatriX, Inc. K.K. and W.H.M. consult with and/or serve on the boards of various biotechnology and pharmaceutical companies from time to time, where they may receive compensati

References

  1. Trans Am Ophthalmol Soc. 1998;96:881-923 - PubMed
  2. N Engl J Med. 2000 Feb 17;342(7):483-92 - PubMed
  3. Diabetes. 2000 Jun;49(6):1006-15 - PubMed
  4. Diabetologia. 2001 Apr;44(4):424-8 - PubMed
  5. Diabetes. 2001 Aug;50(8):1927-37 - PubMed
  6. Vis Neurosci. 2002 Jul-Aug;19(4):395-407 - PubMed
  7. J Cell Physiol. 2003 Mar;194(3):325-40 - PubMed
  8. N Engl J Med. 2003 Jun 26;348(26):2656-68 - PubMed
  9. Arch Ophthalmol. 1964 Dec;72:792-5 - PubMed
  10. Prog Retin Eye Res. 2004 Jan;23(1):53-89 - PubMed
  11. Biochem Pharmacol. 2004 Nov 15;68(10):1971-84 - PubMed
  12. Lancet. 2004 Dec 4-10;364(9450):2045-54 - PubMed
  13. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4302-10 - PubMed
  14. Lancet. 2006 Jul 1;368(9529):70-82 - PubMed
  15. J Nutr. 2006 Aug;136(8):2131-4 - PubMed
  16. Curr Biol. 2006 Jul 25;16(14):R551-60 - PubMed
  17. N Engl J Med. 2006 Oct 5;355(14):1474-85 - PubMed
  18. Can J Ophthalmol. 2007 Jun;42(3):425-38 - PubMed
  19. Altern Med Rev. 2007 Dec;12(4):343-51 - PubMed
  20. Mol Genet Metab. 2008 May;94(1):16-37 - PubMed
  21. Neurosurg Rev. 2008 Apr;31(2):205-13; discussion 213 - PubMed
  22. N Engl J Med. 2008 Jun 12;358(24):2606-17 - PubMed
  23. Prog Retin Eye Res. 2008 Nov;27(6):596-607 - PubMed
  24. Arch Pharm (Weinheim). 2010 Mar;343(3):133-42 - PubMed
  25. Am J Med. 2010 Apr;123(4):374.e1-7 - PubMed
  26. Br J Ophthalmol. 2010 Jan;94(1):121-7 - PubMed
  27. Surv Ophthalmol. 2010 Jul-Aug;55(4):299-334 - PubMed
  28. Lancet Neurol. 2010 Aug;9(8):829-40 - PubMed
  29. Invest Ophthalmol Vis Sci. 2011 Jun 01;52(6):3521-9 - PubMed
  30. PLoS One. 2011 Apr 29;6(4):e19456 - PubMed
  31. Eur J Med Chem. 2011 Nov;46(11):5435-42 - PubMed
  32. Pharmacol Rep. 2011;63(4):849-58 - PubMed
  33. Diabetes Technol Ther. 2012 Mar;14(3):257-63 - PubMed
  34. Pharmacol Res. 2012 Sep;66(3):199-206 - PubMed
  35. Nat Rev Neurol. 2013 Jan;9(1):44-53 - PubMed
  36. Eye Brain. 2010;2:99-116 - PubMed
  37. J Clin Invest. 2013 Apr;123(4):1405-12 - PubMed
  38. Free Radic Biol Med. 2013 Oct;63:1-29 - PubMed
  39. Prog Retin Eye Res. 2013 Nov;37:114-40 - PubMed
  40. Exp Eye Res. 2014 Mar;120:1-9 - PubMed
  41. Exp Gerontol. 2014 Aug;56:182-8 - PubMed
  42. Med Hypothesis Discov Innov Ophthalmol. 2012 Summer;1(2):24-32 - PubMed
  43. J Inherit Metab Dis. 2014 Jul;37(4):553-63 - PubMed
  44. Front Mol Neurosci. 2014 May 08;7:37 - PubMed
  45. Drug Discov Today. 2014 Oct;19(10):1613-22 - PubMed
  46. Cell Death Dis. 2014 Jun 26;5:e1303 - PubMed
  47. Ophthalmology. 2014 Nov;121(11):2081-90 - PubMed
  48. Lancet Glob Health. 2013 Dec;1(6):e339-49 - PubMed
  49. Lancet Glob Health. 2014 Feb;2(2):e106-16 - PubMed
  50. Brain Res Bull. 2014 Oct;109:68-76 - PubMed
  51. Expert Opin Pharmacother. 2014 Dec;15(18):2721-31 - PubMed
  52. Rejuvenation Res. 2015 Feb;18(1):57-89 - PubMed
  53. Antioxid Redox Signal. 2015 Mar 10;22(8):686-729 - PubMed
  54. Neuron. 2015 Jan 21;85(2):257-73 - PubMed
  55. Drug Discov Today. 2015 Sep;20(9):1040-3 - PubMed
  56. J Mol Cell Cardiol. 2015 Jul;84:223-6 - PubMed
  57. Drug Des Devel Ther. 2015 Mar 11;9:1469-79 - PubMed
  58. Drug Dev Res. 2015 Mar;76(2):57-60 - PubMed
  59. Drug Dev Res. 2015 Mar;76(2):72-81 - PubMed
  60. Prog Retin Eye Res. 2015 Sep;48:40-61 - PubMed
  61. Cell Death Differ. 2016 Jan;23(1):89-98 - PubMed
  62. Drug Dev Res. 2015 Jun;76(4):167-75 - PubMed
  63. J Am Coll Nutr. 2016;35(2):175-84 - PubMed
  64. Pharmacol Res. 2015 Sep;99:296-307 - PubMed
  65. ASN Neuro. 2015 Aug 03;7(4):null - PubMed
  66. Immunity. 2015 Aug 18;43(2):343-53 - PubMed
  67. Biochim Biophys Acta. 2015 Nov;1853(11 Pt A):2897-906 - PubMed
  68. Comput Math Methods Med. 2015;2015:923762 - PubMed
  69. Science. 2015 Nov 6;350(6261):636-7 - PubMed
  70. Science. 2015 Nov 6;350(6261):674-7 - PubMed
  71. J Diabetes Complications. 2016 Mar;30(2):350-6 - PubMed
  72. Neurotherapeutics. 2016 Jan;13(1):58-69 - PubMed
  73. Biol Res. 2016 Jan 08;49:4 - PubMed
  74. Expert Opin Ther Targets. 2016 Jun;20(6):721-36 - PubMed
  75. Biochim Biophys Acta. 2016 Oct;1863(10):2422-35 - PubMed
  76. PLoS One. 2016 Feb 17;11(2):e0148042 - PubMed
  77. Sci Transl Med. 2016 Feb 17;8(326):326rv3 - PubMed
  78. Exp Ther Med. 2016 Jan;11(1):6-14 - PubMed
  79. Drug Dev Res. 2016 May;77(3):109-23 - PubMed
  80. Drug Dev Res. 2016 Mar;77(2):53-72 - PubMed
  81. Mol Cell. 2016 Mar 3;61(5):654-666 - PubMed
  82. Clin Sci (Lond). 2016 Aug 1;130(15):1375-87 - PubMed
  83. MBio. 2016 Mar 22;7(2):e00198 - PubMed
  84. Ophthalmic Genet. 2017 Jan-Feb;38(1):67-69 - PubMed
  85. Cell Death Dis. 2016 Apr 07;7:e2179 - PubMed
  86. Microbiol Mol Biol Rev. 2016 Apr 13;80(2):429-50 - PubMed
  87. EBioMedicine. 2016 Feb 04;5:198-203 - PubMed
  88. Biochem J. 2016 Jun 15;473(12):1821-30 - PubMed
  89. Cell Mol Life Sci. 2016 Sep;73(17):3221-47 - PubMed
  90. Circ Res. 2016 Jun 10;118(12):1960-91 - PubMed
  91. Front Neurol. 2016 Apr 19;7:55 - PubMed
  92. Trends Mol Med. 2016 May;22(5):391-403 - PubMed
  93. Biochim Biophys Acta. 2016 Aug;1862(8):1392-400 - PubMed
  94. Biores Open Access. 2016 Apr 01;5(1):94-108 - PubMed
  95. Med Res Rev. 2016 Sep;36(5):924-63 - PubMed
  96. Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2851-63 - PubMed
  97. Cell Mol Life Sci. 2016 Dec;73(24):4577-4590 - PubMed
  98. Eye (Lond). 2016 Oct;30(10):1277-1292 - PubMed
  99. Biores Open Access. 2016 May 01;5(1):137-45 - PubMed
  100. Int J Ophthalmol. 2016 May 18;9(5):780-8 - PubMed
  101. J Anat. 2016 Jul;229(1):32-62 - PubMed
  102. Trends Biochem Sci. 2016 Aug;41(8):700-711 - PubMed
  103. Pharmacol Ther. 2016 Sep;165:132-52 - PubMed
  104. Curr Opin Immunol. 2016 Oct;42:71-75 - PubMed
  105. Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3231-8 - PubMed
  106. Environ Toxicol Pharmacol. 2016 Jul;45:274-81 - PubMed
  107. Mamm Genome. 2016 Aug;27(7-8):381-95 - PubMed
  108. Ageing Res Rev. 2016 Aug;29:90-112 - PubMed
  109. Int J Mol Sci. 2016 Jun 30;17(7): - PubMed
  110. Pediatr Neurol. 2016 Oct;63:3-5 - PubMed
  111. FEBS J. 2017 Jan;284(2):183-195 - PubMed
  112. Mitochondrion. 2017 Sep;36:7-14 - PubMed
  113. Am Fam Physician. 2016 Aug 1;94(3):219-26 - PubMed
  114. Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4035-44 - PubMed
  115. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Jan;1862(1):114-129 - PubMed
  116. Food Chem Toxicol. 2016 Oct;96:191-204 - PubMed
  117. PLoS One. 2016 Aug 09;11(8):e0160887 - PubMed
  118. Mol Nutr Food Res. 2016 Aug;60(8):1731-55 - PubMed
  119. J Neurol Sci. 2016 Sep 15;368:25-31 - PubMed
  120. Nat Immunol. 2016 Aug 19;17(9):1009-10 - PubMed
  121. Prog Retin Eye Res. 2016 Nov;55:206-245 - PubMed
  122. Ophthalmic Res. 2017;57(2):77-86 - PubMed
  123. Cancer Lett. 2017 Jan 1;384:60-69 - PubMed
  124. Pediatr Neurol. 2016 Dec;65:1-13 - PubMed
  125. Biochim Biophys Acta Mol Basis Dis. 2017 Jan;1863(1):21-32 - PubMed
  126. Mol Vis. 2016 Sep 23;22:1122-1136 - PubMed
  127. Mol Nutr Food Res. 2017 Feb;61(2): - PubMed
  128. Drug Dev Res. 2017 Feb;78(1):24-36 - PubMed
  129. Nat Neurosci. 2016 Oct 26;19(11):1408-1417 - PubMed
  130. J Neurosci. 2016 Oct 19;36(42):10707-10722 - PubMed
  131. Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):585-597 - PubMed
  132. Tohoku J Exp Med. 2016;240(3):209-214 - PubMed
  133. Healthcare (Basel). 2016 Nov 15;4(4): - PubMed
  134. Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:535-565 - PubMed
  135. Am J Med Genet C Semin Med Genet. 2016 Dec;172(4):349-366 - PubMed
  136. Pharmacol Res. 2017 Jan;115:96-106 - PubMed
  137. Pediatr Clin North Am. 2017 Feb;64(1):161-171 - PubMed
  138. Exp Eye Res. 2017 Jan;154:151-158 - PubMed
  139. J Mol Biol. 2017 Jan 6;429(1):1-13 - PubMed
  140. Am J Physiol Heart Circ Physiol. 2017 Feb 1;312(2):H201-H212 - PubMed
  141. Mol Nutr Food Res. 2017 Apr;61(4): - PubMed
  142. Ann N Y Acad Sci. 2016 Dec;1386(1):45-68 - PubMed
  143. Eye (Lond). 2017 Feb;31(2):185-190 - PubMed
  144. J Mol Biol. 2017 Feb 17;429(4):497-514 - PubMed
  145. Food Chem Toxicol. 2017 Feb;100:90-102 - PubMed
  146. Antioxid Redox Signal. 2017 Sep 10;27(8):453-471 - PubMed
  147. Free Radic Biol Med. 2017 Feb;103:155-164 - PubMed
  148. Food Chem Toxicol. 2017 Feb;100:175-182 - PubMed
  149. EBioMedicine. 2016 Dec;14:15-23 - PubMed
  150. Med Res Rev. 2017 Sep;37(5):1186-1225 - PubMed
  151. Curr Opin Ophthalmol. 2017 Jan;27 Suppl 1:3-47 - PubMed
  152. Nat Chem Biol. 2017 Jan 19;13(2):136-146 - PubMed
  153. Ophthalmic Epidemiol. 2017 Jun;24(3):141-152 - PubMed
  154. Nat Med. 2017 Mar;23(3):288-290 - PubMed
  155. Nature. 2017 Feb 16;542(7641):367-371 - PubMed
  156. Aging Cell. 2017 Jun;16(3):435-443 - PubMed
  157. Trends Mol Med. 2017 Mar;23(3):201-215 - PubMed
  158. J Exp Med. 2017 Mar 6;214(3):569-578 - PubMed
  159. Am J Rhinol Allergy. 2017 Jan 1;31(1):3-7 - PubMed
  160. Sci Signal. 2017 Feb 28;10(468): - PubMed
  161. Sci Signal. 2017 Feb 28;10(468): - PubMed
  162. Sci Signal. 2017 Feb 28;10(468): - PubMed
  163. J Neurosci Res. 2017 Oct;95(10):2025-2029 - PubMed
  164. EBioMedicine. 2017 Apr;18:19-20 - PubMed
  165. Mitochondrion. 2017 Sep;36:66-76 - PubMed
  166. Nat Rev Immunol. 2017 Jun;17(6):363-375 - PubMed
  167. Nat Immunol. 2017 Apr 18;18(5):488-498 - PubMed
  168. ACS Chem Neurosci. 2017 Jul 19;8(7):1618-1627 - PubMed
  169. Brain. 2017 Jun 1;140(6):1757-1767 - PubMed
  170. Hum Mol Genet. 2017 Aug 1;26(R1):R12-R20 - PubMed
  171. Mitochondrion. 2017 Jul;35:44-53 - PubMed
  172. Ophthalmology. 2017 Sep;124(9):1340-1352 - PubMed
  173. Proc Natl Acad Sci U S A. 2017 May 30;114(22):E4472-E4481 - PubMed
  174. Nat Rev Drug Discov. 2017 Jul;16(7):487-511 - PubMed
  175. F1000Res. 2017 Mar 9;6:245 - PubMed
  176. Sci Rep. 2017 May 24;7(1):2329 - PubMed
  177. Eye Brain. 2011 Sep 26;3:29-47 - PubMed
  178. Mitochondrion. 2017 Sep;36:103-113 - PubMed
  179. Drug Discov Today Technol. 2017 Mar;23:17-25 - PubMed
  180. IUBMB Life. 2017 Aug;69(8):578-594 - PubMed
  181. Chem Rev. 2017 Aug 9;117(15):10043-10120 - PubMed
  182. Food Chem Toxicol. 2017 Sep;107(Pt A):129-137 - PubMed
  183. Int J Mol Sci. 2017 Jun 29;18(7):null - PubMed
  184. Inflamm Res. 2017 Nov;66(11):947-959 - PubMed
  185. Biochem Pharmacol. 2017 Oct 15;142:111-119 - PubMed
  186. Drug Discov Today. 2017 Nov;22(11):1593-1597 - PubMed
  187. J Nutr. 2017 Aug;147(8):1487-1492 - PubMed
  188. Immunity. 2017 Jul 18;47(1):148-158.e5 - PubMed
  189. J AAPOS. 2017 Aug;21(4):259-261 - PubMed
  190. NPJ Aging Mech Dis. 2016 Mar 10;2:16003 - PubMed
  191. Aging Cell. 2017 Oct;16(5):934-942 - PubMed
  192. Immunity. 2017 Jul 18;47(1):6-8 - PubMed
  193. Nature. 2017 Aug 3;548(7665):103-107 - PubMed
  194. Exp Eye Res. 2017 Nov;164:31-36 - PubMed
  195. Drug Discov Today. 2017 Nov;22(11):1671-1679 - PubMed
  196. Arch Biochem Biophys. 2017 Oct 1;631:31-41 - PubMed
  197. Invest Ophthalmol Vis Sci. 2017 May 1;58(6):BIO227-BIO233 - PubMed
  198. JCI Insight. 2017 Aug 17;2(16):null - PubMed
  199. Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7545-E7553 - PubMed
  200. Br J Ophthalmol. 2018 Apr;102(4):465-472 - PubMed
  201. Cell Host Microbe. 2017 Sep 13;22(3):279-290.e7 - PubMed
  202. Prog Retin Eye Res. 2017 Sep;60:1-19 - PubMed
  203. Br J Pharmacol. 2017 Dec;174(23):4205-4223 - PubMed
  204. Life Sci. 2017 Nov 1;188:53-67 - PubMed
  205. Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4593-4600 - PubMed
  206. Ophthalmology. 2018 Feb;125(2):245-254 - PubMed
  207. Lancet Neurol. 2017 Oct;16(10):797-812 - PubMed
  208. Expert Opin Ther Targets. 2017 Nov;21(11):1037-1050 - PubMed
  209. Cell Metab. 2017 Nov 7;26(5):719-737.e6 - PubMed
  210. Lancet Glob Health. 2017 Dec;5(12):e1221-e1234 - PubMed
  211. Vet Sci. 2017 Mar 16;4(1):null - PubMed
  212. Biores Open Access. 2017 Oct 01;6(1):123-132 - PubMed
  213. J Clin Invest. 2017 Dec 1;127(12):4403-4414 - PubMed
  214. J Control Release. 2018 Jan 10;269:45-51 - PubMed
  215. Trends Food Sci Technol. 2017 Nov;69(Pt B):257-269 - PubMed
  216. Neurosci Lett. 1997 Feb 7;222(3):191-4 - PubMed
  217. Gen Pharmacol. 1997 Sep;29(3):315-31 - PubMed
  218. Invest Ophthalmol. 1976 Oct;15(10):808-14 - PubMed

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