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Singh AK, Bodolan AA, Gilbert MP. A False Positive I-131 Metastatic Survey Caused by Radioactive Iodine Uptake by a Benign Thymic Cyst. Case Rep Endocrinol. 2017;2017:6469015doi: 10.1155/2017/6469015.
Singh, A. K., Bodolan, A. A., & Gilbert, M. P. (2017). A False Positive I-131 Metastatic Survey Caused by Radioactive Iodine Uptake by a Benign Thymic Cyst. Case reports in endocrinology, 20176469015. https://doi.org/10.1155/2017/6469015
Singh, Avneet K, et al. "A False Positive I-131 Metastatic Survey Caused by Radioactive Iodine Uptake by a Benign Thymic Cyst." Case reports in endocrinology vol. 2017 (2017): 6469015. doi: https://doi.org/10.1155/2017/6469015
Singh AK, Bodolan AA, Gilbert MP. A False Positive I-131 Metastatic Survey Caused by Radioactive Iodine Uptake by a Benign Thymic Cyst. Case Rep Endocrinol. 2017;2017:6469015. doi: 10.1155/2017/6469015. Epub 2017 Dec 20. PMID: 29423324; PMCID: PMC5750482.
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Case Rep Endocrinol. 2017;2017:6469015. doi: 10.1155/2017/6469015. Epub 2017 Dec 20.

A False Positive I-131 Metastatic Survey Caused by Radioactive Iodine Uptake by a Benign Thymic Cyst.

Case reports in endocrinology

Avneet K Singh, Adina A Bodolan, Matthew P Gilbert

Affiliations

  1. Department of Medicine, The Robert Larner, M.D. College of Medicine at The University of Vermont, Burlington, VT, USA.
  2. Department of Pathology and Laboratory Medicine, The Robert Larner, M.D. College of Medicine at The University of Vermont, Burlington, VT, USA.
  3. Division of Endocrinology and Diabetes, The Robert Larner, M.D. College of Medicine at The University of Vermont, Burlington, VT, USA.

PMID: 29423324 PMCID: PMC5750482 DOI: 10.1155/2017/6469015

Abstract

Thyroid carcinoma is the most common endocrine malignancy in the United States with increasing incidence and diagnosis but stable mortality. Differentiated thyroid cancer rarely presents with distant metastases and is associated with a low risk of morbidity and mortality. Despite this, current protocols recommend remnant ablation with radioactive iodine and evaluation for local and distant metastasis in some patients with higher risk disease. There are several case reports of false positive results of metastatic surveys that are either normal physiologic variants or other pathological findings. Most false positive findings are associated with tissue that has physiologic increased uptake of I-131, such as breast tissue or lung tissue; pathological findings such as thymic cysts are also known to have increased uptake. Our case describes a rare finding of a thymic cyst found on a false positive I-131 metastatic survey. The patient was taken for surgical excision and the final pathology was a benign thymic cyst. Given that pulmonary metastases of differentiated thyroid cancer are rare, thymic cysts, though also rare, must be part of the differential diagnosis for false positive findings on an I-131 survey.

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