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Schaefer E, Wu W, Mark C, et al. Intermittent hypoxia is a proinflammatory stimulus resulting in IL-6 expression and M1 macrophage polarization. Hepatol Commun. 2017;1(4):326-337doi: 10.1002/hep4.1045.
Schaefer, E., Wu, W., Mark, C., Yang, A., DiGiacomo, E., Carlton-Smith, C., Salloum, S., Brisac, C., Lin, W., Corey, K. E., & Chung, R. T. (2017). Intermittent hypoxia is a proinflammatory stimulus resulting in IL-6 expression and M1 macrophage polarization. Hepatology communications, 1(4), 326-337. https://doi.org/10.1002/hep4.1045
Schaefer, Esperance, et al. "Intermittent hypoxia is a proinflammatory stimulus resulting in IL-6 expression and M1 macrophage polarization." Hepatology communications vol. 1,4 (2017): 326-337. doi: https://doi.org/10.1002/hep4.1045
Schaefer E, Wu W, Mark C, Yang A, DiGiacomo E, Carlton-Smith C, Salloum S, Brisac C, Lin W, Corey KE, Chung RT. Intermittent hypoxia is a proinflammatory stimulus resulting in IL-6 expression and M1 macrophage polarization. Hepatol Commun. 2017 May 18;1(4):326-337. doi: 10.1002/hep4.1045. eCollection 2017 Jun. PMID: 29404462; PMCID: PMC5721395.
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Hepatol Commun. 2017 May 18;1(4):326-337. doi: 10.1002/hep4.1045. eCollection 2017 Jun.

Intermittent hypoxia is a proinflammatory stimulus resulting in IL-6 expression and M1 macrophage polarization.

Hepatology communications

Esperance Schaefer, Winona Wu, Christina Mark, Andrew Yang, Erik DiGiacomo, Charles Carlton-Smith, Shadi Salloum, Cynthia Brisac, Wenyu Lin, Kathleen E Corey, Raymond T Chung

Affiliations

  1. Massachusetts General Hospital Gastrointestinal Unit Boston MA.

PMID: 29404462 PMCID: PMC5721395 DOI: 10.1002/hep4.1045

Abstract

The biological factors that promote inflammation or nonalcoholic steatohepatitis (NASH) in the setting of nonalcoholic fatty liver disease remain incompletely understood. Clinical studies have demonstrated an association between obstructive sleep apnea (OSA) and both inflammation and fibrosis in NASH, but the mechanism has not been identified. In this study, we use

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