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Gizaw M, Thompson J, Faglie A, et al. Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications. Bioengineering (Basel). 2018;5(1)doi: 10.3390/bioengineering5010009.
Gizaw, M., Thompson, J., Faglie, A., Lee, S. Y., Neuenschwander, P., & Chou, S. F. (2018). Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications. Bioengineering (Basel, Switzerland), 5(1), . https://doi.org/10.3390/bioengineering5010009
Gizaw, Mulugeta, et al. "Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications." Bioengineering (Basel, Switzerland) vol. 5,1 (2018). doi: https://doi.org/10.3390/bioengineering5010009
Gizaw M, Thompson J, Faglie A, Lee SY, Neuenschwander P, Chou SF. Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications. Bioengineering (Basel). 2018 Jan 27;5(1). doi: 10.3390/bioengineering5010009. PMID: 29382065; PMCID: PMC5874875.
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Bioengineering (Basel). 2018 Jan 27;5(1). doi: 10.3390/bioengineering5010009.

Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications.

Bioengineering (Basel, Switzerland)

Mulugeta Gizaw, Jeffrey Thompson, Addison Faglie, Shih-Yu Lee, Pierre Neuenschwander, Shih-Feng Chou

Affiliations

  1. Department of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, Tyler, TX 75799, USA. [email protected].
  2. Department of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, Tyler, TX 75799, USA. [email protected].
  3. Department of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, Tyler, TX 75799, USA. [email protected].
  4. School of Nursing, College of Nursing and Health Sciences, The University of Texas at Tyler, Tyler, TX 75799, USA. [email protected].
  5. Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA. [email protected].
  6. Department of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, Tyler, TX 75799, USA. [email protected].

PMID: 29382065 PMCID: PMC5874875 DOI: 10.3390/bioengineering5010009

Abstract

Wound healing is a complex tissue regeneration process that promotes the growth of new tissue to provide the body with the necessary barrier from the outside environment. In the class of non-healing wounds, diabetic wounds, and ulcers, dressing materials that are available clinically (e.g., gels and creams) have demonstrated only a slow improvement with current available technologies. Among all available current technologies, electrospun fibers exhibit several characteristics that may provide novel replacement dressing materials for the above-mentioned wounds. Therefore, in this review, we focus on recent achievements in electrospun drug-eluting fibers for wound healing applications. In particular, we review drug release, including small molecule drugs, proteins and peptides, and gene vectors from electrospun fibers with respect to wound healing. Furthermore, we provide an overview on multifunctional dressing materials based on electrospun fibers, including those that are capable of achieving wound debridement and wound healing simultaneously as well as multi-drugs loading/types suitable for various stages of the healing process. Our review provides important and sufficient information to inform the field in development of fiber-based dressing materials for clinical treatment of non-healing wounds.

Keywords: composites; drug release; electrospun fibers; gene vectors; proteins and peptides; small molecule drugs

Conflict of interest statement

The authors declare no conflict of interest.

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