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Huleyuk N, Tkach I, Zastavna D, et al. Can telomere shortening be the main indicator of non-viable fetus elimination?. Mol Cytogenet. 2018;11:11doi: 10.1186/s13039-018-0361-9.
Huleyuk, N., Tkach, I., Zastavna, D., & Tyrka, M. (2018). Can telomere shortening be the main indicator of non-viable fetus elimination?. Molecular cytogenetics, 1111. https://doi.org/10.1186/s13039-018-0361-9
Huleyuk, Nataliya, et al. "Can telomere shortening be the main indicator of non-viable fetus elimination?." Molecular cytogenetics vol. 11 (2018): 11. doi: https://doi.org/10.1186/s13039-018-0361-9
Huleyuk N, Tkach I, Zastavna D, Tyrka M. Can telomere shortening be the main indicator of non-viable fetus elimination?. Mol Cytogenet. 2018 Jan 25;11:11. doi: 10.1186/s13039-018-0361-9. eCollection 2018. PMID: 29416566; PMCID: PMC5785879.
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Mol Cytogenet. 2018 Jan 25;11:11. doi: 10.1186/s13039-018-0361-9. eCollection 2018.

Can telomere shortening be the main indicator of non-viable fetus elimination?.

Molecular cytogenetics

Nataliya Huleyuk, Iryna Tkach, Danuta Zastavna, Miroslaw Tyrka

Affiliations

  1. 1Institute of Hereditary Pathology, NAMS of Ukraine, Lysenko Str. 31a, Lviv, 79008 Ukraine.
  2. 2Department of Biotechnology and Bioinformatics, Faculty of Chemistry, Rzeszow University of Technology, Al. Powsta?ców Warszawy 6, 35-959 Rzeszow, Poland.

PMID: 29416566 PMCID: PMC5785879 DOI: 10.1186/s13039-018-0361-9

Abstract

BACKGROUND: Telomeres are transcriptionally inactive genomic areas, which, if shortened, are associated with pathological processes, unsuccessful fertilization, aging, and death. Telomere dysfunction has also been linked to chromosomal rearrangements and genomic instability. The role of telomeres in postnatal life has been extensively studied and discussed both in physiological as well as in pathological processes. However, the role of telomere length in prenatal development is still poorly understood, and mainly concerns the preimplantation stage. The aim of this study was to estimate relative telomere length in spontaneously eliminated human embryos between 5th and 12th week of gestation.

RESULTS: Relative telomere length was measured from total genomic DNA using a real-time polymerase chain reaction approach. In this study, we examined relative telomere length in 80 spontaneously eliminated embryos and in 25 embryos eliminated due to induced abortions. Relative telomere length in spontaneous abortions was significantly lower (

CONCLUSION: Spontaneously lost pregnancies are characterized by shortened telomeres, especially in embryos with aneuploidies. We hypothesize that the shortening of telomeres is involved in the processes leading to spontaneous abortions.

Keywords: Aneuploidy; Euploidy; Relative telomere length; Spontaneous abortions

Conflict of interest statement

The study was approved by the bioethics committee of the Institute of Hereditary Pathology NAMS of Ukraine. Informed consent was obtained from all the participants.Not applicable.The authors declare t

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