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Nikitina LE, Kiselev SV, Startseva VA, et al. Sulfur-Containing Monoterpenoids as Potential Antithrombotic Drugs: Research in the Molecular Mechanism of Coagulation Activity Using Pinanyl Sulfoxide as an Example. Front Pharmacol. 2018;9:116doi: 10.3389/fphar.2018.00116.
Nikitina, L. E., Kiselev, S. V., Startseva, V. A., Bodrov, A. V., Azizova, Z. R., Shipina, O. T., Fedyunina, I. V., Boichuk, S. V., Lodochnikova, O. A., Klochkov, V. V., Galiullina, L. F., & Khaliullina, A. V. (2018). Sulfur-Containing Monoterpenoids as Potential Antithrombotic Drugs: Research in the Molecular Mechanism of Coagulation Activity Using Pinanyl Sulfoxide as an Example. Frontiers in pharmacology, 9116. https://doi.org/10.3389/fphar.2018.00116
Nikitina, Liliya E, et al. "Sulfur-Containing Monoterpenoids as Potential Antithrombotic Drugs: Research in the Molecular Mechanism of Coagulation Activity Using Pinanyl Sulfoxide as an Example." Frontiers in pharmacology vol. 9 (2018): 116. doi: https://doi.org/10.3389/fphar.2018.00116
Nikitina LE, Kiselev SV, Startseva VA, Bodrov AV, Azizova ZR, Shipina OT, Fedyunina IV, Boichuk SV, Lodochnikova OA, Klochkov VV, Galiullina LF, Khaliullina AV. Sulfur-Containing Monoterpenoids as Potential Antithrombotic Drugs: Research in the Molecular Mechanism of Coagulation Activity Using Pinanyl Sulfoxide as an Example. Front Pharmacol. 2018 Feb 19;9:116. doi: 10.3389/fphar.2018.00116. eCollection 2018. PMID: 29515444; PMCID: PMC5825891.
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Front Pharmacol. 2018 Feb 19;9:116. doi: 10.3389/fphar.2018.00116. eCollection 2018.

Sulfur-Containing Monoterpenoids as Potential Antithrombotic Drugs: Research in the Molecular Mechanism of Coagulation Activity Using Pinanyl Sulfoxide as an Example.

Frontiers in pharmacology

Liliya E Nikitina, Sergei V Kiselev, Valeriya A Startseva, Andrei V Bodrov, Zulfiya R Azizova, Olga T Shipina, Inna V Fedyunina, Sergei V Boichuk, Olga A Lodochnikova, Vladimir V Klochkov, Leisan F Galiullina, Aliya V Khaliullina

Affiliations

  1. Department of General and Organic Chemistry, Kazan State Medical University, Kazan, Russia.
  2. Medical Physics Department, Institute of Physics, Kazan Federal University, Kazan, Russia.
  3. Department of Chemistry and Technology of Macromolecular Compounds, Kazan National Research Technological University, Kazan, Russia.
  4. A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russia.

PMID: 29515444 PMCID: PMC5825891 DOI: 10.3389/fphar.2018.00116

Abstract

In this article we present the synthesis of enantiomerically pure sulfoxide and study the influence of this compound on hemostasis. Detailed NMR studies and molecular dynamics simulations using sodium dodecyl sulfate (SDS) membrane models indicated that the bicyclic fragment of sulfoxide was embedded into the SDS micelle whereas the -SO(CH

Keywords: coagulation activity; molecular mechanism of coagulation activity; platelets aggregation; sulfoxides; terpenes

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