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Li Y, Finkbeiner S, Ganner A, et al. CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in . Oncotarget. 2018;9(11):9581-9595doi: 10.18632/oncotarget.24039.
Li, Y., Finkbeiner, S., Ganner, A., Gerber, J., Klein, M., Grafe, M., Kandzia, J., Thien, A., Thedieck, K., Breves, G., Jank, T., Baumeister, R., Walz, G., & Neumann-Haefelin, E. (2018). CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in . Oncotarget, 9(11), 9581-9595. https://doi.org/10.18632/oncotarget.24039
Li, Yujie, et al. "CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in ." Oncotarget vol. 9,11 (2018): 9581-9595. doi: https://doi.org/10.18632/oncotarget.24039
Li Y, Finkbeiner S, Ganner A, Gerber J, Klein M, Grafe M, Kandzia J, Thien A, Thedieck K, Breves G, Jank T, Baumeister R, Walz G, Neumann-Haefelin E. CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in . Oncotarget. 2018 Jan 06;9(11):9581-9595. doi: 10.18632/oncotarget.24039. eCollection 2018 Feb 09. PMID: 29515755; PMCID: PMC5839386.
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Oncotarget. 2018 Jan 06;9(11):9581-9595. doi: 10.18632/oncotarget.24039. eCollection 2018 Feb 09.

CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in .

Oncotarget

Yujie Li, Sandra Finkbeiner, Athina Ganner, Julia Gerber, Marinella Klein, Manuel Grafe, Jakob Kandzia, Antje Thien, Kathrin Thedieck, Gerhard Breves, Thomas Jank, Ralf Baumeister, Gerd Walz, Elke Neumann-Haefelin

Affiliations

  1. Department of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany.
  2. Department of Physiology, University of Veterinary Medicine Hannover, Hannover, Germany.
  3. Bioinformatics and Molecular Genetics, Faculty of Biology, Albert-Ludwigs-University Freiburg, Freiburg, Germany.
  4. Department of Pediatrics, Section Systems Medicine of Metabolism and Signaling, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  5. Department for Neuroscience, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
  6. Institute for Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Freiburg, Germany.
  7. Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs-University of Freiburg, Freiburg, Germany.
  8. Centre for Biological Systems Analysis (ZBSA), Albert-Ludwigs-University Freiburg, Freiburg, Germany.
  9. ZBMZ Centre for Biochemistry and Molecular Cell Research, Faculty of Medicine, Albert-Ludwigs-University Freiburg, Freiburg, Germany.

PMID: 29515755 PMCID: PMC5839386 DOI: 10.18632/oncotarget.24039

Abstract

The mechanistic target of rapamycin (mTOR) kinase is central to metabolism and growth, and has a conserved role in aging. mTOR functions in two complexes, mTORC1 and mTORC2. In diverse eukaryotes, inhibition of mTORC1 signaling increases lifespan. mTORC1 transduces anabolic signals to stimulate protein synthesis and inhibits autophagy. In this study, we demonstrate that CGEF-1, the

Keywords: C. elegans; Rheb; aging; mTORC1 signaling; stress response

Conflict of interest statement

CONFLICTS OF INTEREST None.

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