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Andrade XA, Fuentes HE, Oramas DM, et al. Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid Arthritis. Case Rep Hematol. 2018;2018:8097965doi: 10.1155/2018/8097965.
Andrade, X. A., Fuentes, H. E., Oramas, D. M., Mann, H., & Kovarik, P. (2018). Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid Arthritis. Case reports in hematology, 20188097965. https://doi.org/10.1155/2018/8097965
Andrade, X A, et al. "Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid Arthritis." Case reports in hematology vol. 2018 (2018): 8097965. doi: https://doi.org/10.1155/2018/8097965
Andrade XA, Fuentes HE, Oramas DM, Mann H, Kovarik P. Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid Arthritis. Case Rep Hematol. 2018 Jan 11;2018:8097965. doi: 10.1155/2018/8097965. eCollection 2018. PMID: 29515924; PMCID: PMC5821964.
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Case Rep Hematol. 2018 Jan 11;2018:8097965. doi: 10.1155/2018/8097965. eCollection 2018.

Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid Arthritis.

Case reports in hematology

X A Andrade, H E Fuentes, D M Oramas, H Mann, P Kovarik

Affiliations

  1. Department of Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, IL, USA.
  2. Division of Pathology, University of Illinois at Chicago, Chicago, IL, USA.
  3. Department of Pathology, John H. Stroger Jr. Hospital of Cook County, Chicago, IL, USA.

PMID: 29515924 PMCID: PMC5821964 DOI: 10.1155/2018/8097965

Abstract

Patients with rheumatoid arthritis are at increased risk of hematological malignancies, especially when exposed to immunosuppressive therapy. The mechanisms of lymphomagenesis remain poorly understood but factors implicated include high disease activity, exposure to antitumoral necrosis factor medications, and Epstein-Barr virus infection. Lymphoid malignancies of T-cell origin are uncommon in patients with rheumatoid arthirits. Clinical presentation with associated hemophagocytic lymphohistiocyotsis is rare and confers a poor prognosis. This case report illustrates a case of a patient with long-standing rheumatoid arthritis and an iatrogenic peripheral T-cell lymphoma with secondary hemophagocytic lymphohistiocytosis who achieved a complete response after intensive chemotherapy.

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