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Miszuk JM, Xu T, Yao Q, et al. Functionalization of PCL-3D Electrospun Nanofibrous Scaffolds for Improved BMP2-Induced Bone Formation. Appl Mater Today. 2017;10:194-202doi: 10.1016/j.apmt.2017.12.004.
Miszuk, J. M., Xu, T., Yao, Q., Fang, F., Childs, J. D., Hong, Z., Tao, J., Fong, H., & Sun, H. (2018). Functionalization of PCL-3D Electrospun Nanofibrous Scaffolds for Improved BMP2-Induced Bone Formation. Applied materials today, 10194-202. https://doi.org/10.1016/j.apmt.2017.12.004
Miszuk, Jacob M, et al. "Functionalization of PCL-3D Electrospun Nanofibrous Scaffolds for Improved BMP2-Induced Bone Formation." Applied materials today vol. 10 (2018): 194-202. doi: https://doi.org/10.1016/j.apmt.2017.12.004
Miszuk JM, Xu T, Yao Q, Fang F, Childs JD, Hong Z, Tao J, Fong H, Sun H. Functionalization of PCL-3D Electrospun Nanofibrous Scaffolds for Improved BMP2-Induced Bone Formation. Appl Mater Today. 2018 Mar;10:194-202. doi: 10.1016/j.apmt.2017.12.004. Epub 2017 Dec 14. PMID: 29577064; PMCID: PMC5863927.
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Appl Mater Today. 2018 Mar;10:194-202. doi: 10.1016/j.apmt.2017.12.004. Epub 2017 Dec 14.

Functionalization of PCL-3D Electrospun Nanofibrous Scaffolds for Improved BMP2-Induced Bone Formation.

Applied materials today

Jacob M Miszuk, Tao Xu, Qingqing Yao, Fang Fang, Josh D Childs, Zhongkui Hong, Jianning Tao, Hao Fong, Hongli Sun

Affiliations

  1. Department of Biomedical Engineering, University of South Dakota, BioSNTR, Sioux Falls, SD 57107, USA.
  2. Program of Biomedical Engineering, South Dakota School of Mines and Technology, Rapid City, SD 57701, USA.
  3. Children's Health Research Center at Sanford Research, Sioux Falls, SD 57104, USA.

PMID: 29577064 PMCID: PMC5863927 DOI: 10.1016/j.apmt.2017.12.004

Abstract

Bone morphogenic protein 2 (BMP2) is a key growth factor for bone regeneration, possessing FDA approval for orthopedic applications. BMP2 is often required in supratherapeutic doses clinically, yielding adverse side effects and substantial treatment costs. Considering the crucial role of materials for BMPs delivery and cell osteogenic differentiation, we devote to engineering an innovative bone-matrix mimicking niche to improve low dose of BMP2-induced bone formation. Our previous work describes a novel technique, named thermally induced nanofiber self-agglomeration (TISA), for generating 3D electrospun nanofibrous (NF) polycaprolactone (PCL) scaffolds. TISA process could readily blend PCL with PLA, leading to increased osteogenic capabilities

Keywords: 3D electrospun nanofibrous scaffold; Bone Regeneration; Hydroxyapatite functionalization; Osteogenic differentiation; Phenamil

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