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Khokhar B, Simoni-Wastila L, Slejko JF, et al. Patterns of Statin Use in Older Medicare Beneficiaries With Traumatic Brain Injury. J Pharm Technol. 2017;33(4):156-166doi: 10.1177/8755122517710671.
Khokhar, B., Simoni-Wastila, L., Slejko, J. F., Perfetto, E., Zhan, M., & Smith, G. S. (2017). Patterns of Statin Use in Older Medicare Beneficiaries With Traumatic Brain Injury. The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians, 33(4), 156-166. https://doi.org/10.1177/8755122517710671
Khokhar, Bilal, et al. "Patterns of Statin Use in Older Medicare Beneficiaries With Traumatic Brain Injury." The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians vol. 33,4 (2017): 156-166. doi: https://doi.org/10.1177/8755122517710671
Khokhar B, Simoni-Wastila L, Slejko JF, Perfetto E, Zhan M, Smith GS. Patterns of Statin Use in Older Medicare Beneficiaries With Traumatic Brain Injury. J Pharm Technol. 2017;33(4):156-166. doi: 10.1177/8755122517710671. Epub 2017 May 23. PMID: 29577114; PMCID: PMC5863738.
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J Pharm Technol. 2017;33(4):156-166. doi: 10.1177/8755122517710671. Epub 2017 May 23.

Patterns of Statin Use in Older Medicare Beneficiaries With Traumatic Brain Injury.

The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians

Bilal Khokhar, Linda Simoni-Wastila, Julia F Slejko, Eleanor Perfetto, Min Zhan, Gordon S Smith

Affiliations

  1. University of Maryland, Baltimore, MD, USA.
  2. National Health Council, Washington, DC, USA.
  3. West Virginia University, Morgantown, WV, USA.

PMID: 29577114 PMCID: PMC5863738 DOI: 10.1177/8755122517710671

Abstract

BACKGROUND: In addition to lowering lipids, statins also may be beneficial for older adults sustaining a traumatic brain injury (TBI), as statin use prior to and following trauma may decrease mortality following injury. However, despite statins' potential to reduce mortality, there is limited research regarding statin use among older adults.

OBJECTIVE: To characterize and investigate factors associated with statin use among older adults with TBI.

METHODS: A retrospective drug utilization study was used to characterize statin use among Medicare beneficiaries 65 and older hospitalized with a TBI during 2006 to 2010 and with continuous Medicare Parts A, B, and D coverage 6 months prior and 12 months following TBI. Logistic regression was used to investigate the factors associated with statin use. The exposure of interest was statin use prior to and following TBI.

RESULTS: Of the 75 698 beneficiaries included in the study, 37 874 (~50%) of beneficiaries used a statin at least once during the study period. The most common statin used was simvastatin, while fluvastatin was the least used statin. Statin users were more likely to have cardiovascular diseases when compared to nonusers. Hyperlipidemia was a major factor associated with statin use and had the greatest impact on statin use compared to nonuse (odds ratio = 9.54; 95% confidence interval = 9.07, 10.03).

CONCLUSIONS: This national sample of older adults with TBI suggests that statins are commonly used. Future studies must next examine the impact of statin use on mortality and secondary injury in order to shape pharmacological therapy guidelines following TBI.

Keywords: cardiovascular drugs; drug utilization; geriatrics; pharmacoepidemiology; trauma medicine

Conflict of interest statement

Declaration of Conflicting Interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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