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Drayer SM, Laufer LR, Farrell ME. Autoimmune Progesterone Dermatitis Mistaken for Stevens-Johnson Syndrome. Obstet Gynecol. 2018;131(4):723-726doi: 10.1097/AOG.0000000000002537.
Drayer, S. M., Laufer, L. R., & Farrell, M. E. (2018). Autoimmune Progesterone Dermatitis Mistaken for Stevens-Johnson Syndrome. Obstetrics and gynecology, 131(4), 723-726. https://doi.org/10.1097/AOG.0000000000002537
Drayer, Sara M, et al. "Autoimmune Progesterone Dermatitis Mistaken for Stevens-Johnson Syndrome." Obstetrics and gynecology vol. 131,4 (2018): 723-726. doi: https://doi.org/10.1097/AOG.0000000000002537
Drayer SM, Laufer LR, Farrell ME. Autoimmune Progesterone Dermatitis Mistaken for Stevens-Johnson Syndrome. Obstet Gynecol. 2018 Apr;131(4):723-726. doi: 10.1097/AOG.0000000000002537. PMID: 29528935.
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Obstet Gynecol. 2018 Apr;131(4):723-726. doi: 10.1097/AOG.0000000000002537.

Autoimmune Progesterone Dermatitis Mistaken for Stevens-Johnson Syndrome.

Obstetrics and gynecology

Sara M Drayer, Larry R Laufer, Maureen E Farrell

Affiliations

  1. Departments of Obstetrics and Gynecology and Reproductive Endocrinology and Infertility, Naval Medical Center San Diego, San Diego, California.

PMID: 29528935 DOI: 10.1097/AOG.0000000000002537

Abstract

BACKGROUND: Autoimmune progesterone dermatitis is an uncommon disease presenting with cyclical skin eruptions corresponding with the menstrual cycle luteal phase. Because symptoms are precipitated by rising progesterone levels, treatment relies on hormone suppression.

CASE: A 22-year-old nulligravid woman presented with symptoms mistaken for Stevens-Johnson syndrome. A cyclic recurrence of symptoms occurred, and the diagnosis of autoimmune progesterone dermatitis was made by an intradermal progesterone challenge. After 48 months, her disease remained refractory to medical management, and definitive surgical treatment with bilateral oophorectomy was performed.

CONCLUSIONS: Autoimmune progesterone dermatitis is a challenging diagnosis as a result of its rarity and variety of clinical presentations. Treatment centers on suppression of endogenous progesterone and avoidance of exogenous triggers. When these modalities fail, surgical management must be undertaken.

References

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