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Dai MH, Zheng H, Zeng LD, et al. The genes associated with early-onset Alzheimer's disease. Oncotarget. 2017;9(19):15132-15143doi: 10.18632/oncotarget.23738.
Dai, M. H., Zheng, H., Zeng, L. D., & Zhang, Y. (2018). The genes associated with early-onset Alzheimer's disease. Oncotarget, 9(19), 15132-15143. https://doi.org/10.18632/oncotarget.23738
Dai, Meng-Hui, et al. "The genes associated with early-onset Alzheimer's disease." Oncotarget vol. 9,19 (2018): 15132-15143. doi: https://doi.org/10.18632/oncotarget.23738
Dai MH, Zheng H, Zeng LD, Zhang Y. The genes associated with early-onset Alzheimer's disease. Oncotarget. 2017 Dec 15;9(19):15132-15143. doi: 10.18632/oncotarget.23738. eCollection 2018 Mar 13. PMID: 29599933; PMCID: PMC5871104.
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Oncotarget. 2017 Dec 15;9(19):15132-15143. doi: 10.18632/oncotarget.23738. eCollection 2018 Mar 13.

The genes associated with early-onset Alzheimer's disease.

Oncotarget

Meng-Hui Dai, Hui Zheng, Ling-Dan Zeng, Yan Zhang

Affiliations

  1. Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  2. Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

PMID: 29599933 PMCID: PMC5871104 DOI: 10.18632/oncotarget.23738

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accounts for the most cases of dementia, which is characterized by the deposition of dense plaques of amyloid beta (Aβ) plaques and neurofibrillary tangles consisting of hyperphosphorylated tau. The two main types of AD can be classified as early-onset AD (EOAD, onset < 65 years) and late-onset AD (LOAD, onset ≥ 65 years). Evidence from family and twin studies indicate that genetic factors are estimated to play a role in at least 80% of AD cases. The first milestone with linkage analysis revealed the mutations in

Keywords: APP; Alzheimer’s disease; PSEN1; PSEN2; early-onset AD

Conflict of interest statement

CONFLICTS OF INTEREST None.

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