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ACS Nano. 2018 Jun 26;12(6):5408-5416. doi: 10.1021/acsnano.8b00448. Epub 2018 May 22.

Rapid Growth of Acetylated Aβ(16-20) into Macroscopic Crystals.

ACS nano

Christian Bortolini, Lasse Hyldgaard Klausen, Søren Vrønning Hoffmann, Nykola C Jones, Daniela Saadeh, Zegao Wang, Tuomas P J Knowles, Mingdong Dong

Affiliations

  1. Interdisciplinary Nanoscience Center , Aarhus University , Aarhus 8000 , Denmark.
  2. Department of Chemistry , University of Cambridge , Cambridge CB2 1TN , U.K.
  3. Department of Chemistry , Stanford University , Stanford , California 94305 , United States.
  4. ISA, Department of Physics and Astronomy , Aarhus University , Aarhus 8000 , Denmark.
  5. Centre for Astronomy & Particle Theory , University of Nottingham , Nottingham NG7 2RD , U.K.

PMID: 29771495 DOI: 10.1021/acsnano.8b00448

Abstract

Aberrant assembly of the amyloid-β (Aβ) is responsible for the development of Alzheimer's disease, but can also be exploited to obtain highly functional biomaterials. The short Aβ fragment, KLVFF (Aβ

Keywords: amyloid crystals; atomic force microscopy; biomaterials; circular dichroism; protein misfolding; self-assembly; stopped-flow

Publication Types

Grant support