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Yakhine-Diop SMS, Rodríguez-Arribas M, Martínez-Chacón G, et al. Acetylome in Human Fibroblasts From Parkinson's Disease Patients. Front Cell Neurosci. 2018;12:97doi: 10.3389/fncel.2018.00097.
Yakhine-Diop, S. M. S., Rodríguez-Arribas, M., Martínez-Chacón, G., Uribe-Carretero, E., Gómez-Sánchez, R., Aiastui, A., López de Munain, A., Bravo-San Pedro, J. M., Niso-Santano, M., González-Polo, R. A., & Fuentes, J. M. (2018). Acetylome in Human Fibroblasts From Parkinson's Disease Patients. Frontiers in cellular neuroscience, 1297. https://doi.org/10.3389/fncel.2018.00097
Yakhine-Diop, Sokhna M S, et al. "Acetylome in Human Fibroblasts From Parkinson's Disease Patients." Frontiers in cellular neuroscience vol. 12 (2018): 97. doi: https://doi.org/10.3389/fncel.2018.00097
Yakhine-Diop SMS, Rodríguez-Arribas M, Martínez-Chacón G, Uribe-Carretero E, Gómez-Sánchez R, Aiastui A, López de Munain A, Bravo-San Pedro JM, Niso-Santano M, González-Polo RA, Fuentes JM. Acetylome in Human Fibroblasts From Parkinson's Disease Patients. Front Cell Neurosci. 2018 Apr 17;12:97. doi: 10.3389/fncel.2018.00097. eCollection 2018. PMID: 29719501; PMCID: PMC5913320.
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Front Cell Neurosci. 2018 Apr 17;12:97. doi: 10.3389/fncel.2018.00097. eCollection 2018.

Acetylome in Human Fibroblasts From Parkinson's Disease Patients.

Frontiers in cellular neuroscience

Sokhna M S Yakhine-Diop, Mario Rodríguez-Arribas, Guadalupe Martínez-Chacón, Elisabet Uribe-Carretero, Rubén Gómez-Sánchez, Ana Aiastui, Adolfo López de Munain, José M Bravo-San Pedro, Mireia Niso-Santano, Rosa A González-Polo, José M Fuentes

Affiliations

  1. Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Madrid, Spain.
  2. Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupacional, Universidad de Extremadura, Cáceres, Spain.
  3. Department of Cell Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
  4. Cell Culture Plataform, Donostia University Hospital, San Sebastián, Spain.
  5. Neuroscience Area of Biodonostia Health Research Institute, Donostia University Hospital, San Sebastián, Spain.
  6. Department of Neurology, Donostia University Hospital, San Sebastian, Spain.
  7. Ilundain Fundazioa, San Sebastian, Spain.
  8. Department of Neurosciences, University of the Basque Country UPV-EHU, San Sebastián, Spain.
  9. Equipe 11 labellisèe Ligue Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.
  10. INSERM U1138, Paris, France.
  11. Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France.
  12. Université Pierre et Marie Curie/Paris VI, Paris, France.
  13. Gustave Roussy Comprehensive Cancer Institute, Villejuif, France.

PMID: 29719501 PMCID: PMC5913320 DOI: 10.3389/fncel.2018.00097

Abstract

Parkinson's disease (PD) is a multifactorial neurodegenerative disorder. The pathogenesis of this disease is associated with gene and environmental factors. Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent genetic cause of familial and sporadic PD. Moreover, posttranslational modifications, including protein acetylation, are involved in the molecular mechanism of PD. Acetylation of lysine proteins is a dynamic process that is modulated in PD. In this descriptive study, we characterized the acetylated proteins and peptides in primary fibroblasts from idiopathic PD (IPD) and genetic PD harboring G2019S or R1441G

Keywords: LRRK2; Parkinson; acetylation; peptides; proteins

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