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Showing 1 to 12 of 303 entries
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Deliberate Integration of Student Leadership Development in Doctor of Pharmacy Programs.

American journal of pharmaceutical education

Janke KK, Nelson MH, Bzowyckyj AS, Fuentes DG, Rosenberg E, DiCenzo R.
PMID: 26941428
Am J Pharm Educ. 2016 Feb 25;80(1):2. doi: 10.5688/ajpe8012.

The CAPE 2013 Outcomes answered the call for increased student leadership development (SLD) by identifying leadership as a desired curricular goal. To meet this outcome, colleges and schools of pharmacy are advised to first identify a set of SLD...

Understanding a Hydroformylation Catalyst that Produces Branched Aldehydes from Alkyl Alkenes.

Journal of the American Chemical Society

Dingwall P, Fuentes JA, Crawford, Slawin AMZ, Bühl M, Clarke ML.
PMID: 29068679
J Am Chem Soc. 2017 Nov 08;139(44):15921-15932. doi: 10.1021/jacs.7b09164. Epub 2017 Oct 25.

This paper reports experimental and computational studies on the mechanism of a rhodium-catalyzed hydroformylation that is selective for branched aldehyde products from unbiased alkene substrates. This highly unusual selectivity relies on a phospholane-phosphite ligand prosaically called BOBPHOS. Kinetic studies...

A Simple PB/LIE Free Energy Function Accurately Predicts the Peptide Binding Specificity of the Tiam1 PDZ Domain.

Frontiers in molecular biosciences

Panel N, Sun YJ, Fuentes EJ, Simonson T.
PMID: 29018806
Front Mol Biosci. 2017 Sep 26;4:65. doi: 10.3389/fmolb.2017.00065. eCollection 2017.

PDZ domains generally bind short amino acid sequences at the C-terminus of target proteins, and short peptides can be used as inhibitors or model ligands. Here, we used experimental binding assays and molecular dynamics simulations to characterize 51 complexes...

mRNA and protein dataset of autophagy markers (LC3 and p62) in several cell lines.

Data in brief

Gómez-Sánchez R, Yakhine-Diop SM, Rodríguez-Arribas M, Bravo-San Pedro JM, Martínez-Chacón G, Uribe-Carretero E, Pinheiro de Castro DC, Pizarro-Estrella E, Fuentes JM, González-Polo RA.
PMID: 27054171
Data Brief. 2016 Mar 09;7:641-7. doi: 10.1016/j.dib.2016.02.085. eCollection 2016 Jun.

We characterized the dynamics of autophagy in vitro using four different cell systems and analyzing markers widely used in this field, i.e. LC3 (microtubule-associated protein 1 light chain 3; protein recruited from the cytosol (LC3-I) to the autophagosomal membrane...

Identification of Plant Extracts that Inhibit the Formation of Diabetes-Linked IAPP Amyloid.

Journal of herbal medicine

Fuentes AL, Hennessy K, Pascual J, Pepe N, Wang I, Santiago A, Chaggan C, Martinez J, Rivera E, Cota P, Cunha C, Nogaj LA, Moffet DA.
PMID: 27042401
J Herb Med. 2016 Mar;6(1):37-41. doi: 10.1016/j.hermed.2015.11.001.

The extracts of 27 vegetables, spices and herbs were screened for their functional ability to inhibit the aggregation of islet amyloid polypeptide (IAPP, amylin) into toxic amyloid aggregates. The aggregation of IAPP has been directly linked to the death...

New Strategies for the Synthesis of Fluorinated Vinylogous Amidines and beta-Enamino Ketones.

The Journal of organic chemistry

Fustero S, García De La Torre M, Pina B, Fuentes AS.
PMID: 11674620
J Org Chem. 1999 Jul 23;64(15):5551-5556. doi: 10.1021/jo990392w.

Reaction of fluorinated imidoyl chlorides 3 with ketimines 1a provides fluorinated 1,3-diimines, which were exclusively isolated as vinylogous amidine tautomers 2beta, with good yields. Fluorinated beta-enamino ketones 4 are obtained by regioselective hydrolysis of 2. Complementary methods for the...

Estimates of DNA strand breakage in bottlenose dolphin (Tursiops truncatus) leukocytes measured with the Comet and DNA diffusion assays.

Genetics and molecular biology

Díaz A, Carro S, Santiago L, Estévez J, Guevara C, Blanco M, Sánchez L, Sánchez L, López N, Cruz D, López R, Cuetara EB, Fuentes JL.
PMID: 21637693
Genet Mol Biol. 2009 Apr;32(2):367-72. doi: 10.1590/S1415-47572009005000030. Epub 2009 Mar 06.

The analysis of DNA damage by mean of Comet or single cell gel electrophoresis (SCGE) assay has been commonly used to assess genotoxic impact in aquatic animals being able to detect exposure to low concentrations of contaminants in a...

Testing Lack of Symmetry in Spatial-Temporal Processes.

Journal of statistical planning and inference

Park MS, Fuentes M.
PMID: 19337579
J Stat Plan Inference. 2008 Oct 01;138(10):2847-2866. doi: 10.1016/j.jspi.2007.10.021.

Symmetry and separability of spatial-temporal covariances are the main assumptions that are frequently taken for granted in most applications because of the simplicity of constructing covariance structure. However, many studies in environmental sciences show that real data have complex...

Statistical issues in health impact assessment at the state and local levels.

Air quality, atmosphere, & health

Fuentes M.
PMID: 19888447
Air Qual Atmos Health. 2009 Mar 01;2(1):47-55. doi: 10.1007/s11869-009-0033-3.

In this work we discuss the uncertainty in estimating the human health risk due to exposure to air pollution, including personal and population average exposure error, epidemiological designs and methods of analysis. Different epidemiological models may lead to very...

Spinal cord toxoplasmosis as an unusual presentation of AIDS: case report and review of the literature.

International journal of emergency medicine

Garcia-Gubern C, Fuentes CR, Colon-Rolon L, Masvidal D.
PMID: 21373318
Int J Emerg Med. 2010 Sep 07;3(4):439-42. doi: 10.1007/s12245-010-0207-7.

Approximately 10% of patients with AIDS present with some neurological deficit as their initial complaint, and up to 80% will have CNS involvement during the course of their disease. Toxoplasmosis is the most common cause of cerebral mass lesions...

A class of nonseparable and nonstationary spatial temporal covariance functions.

Environmetrics

Fuentes M, Chen L, Davis JM.
PMID: 19829763
Environmetrics. 2007 Nov 05;19(5):487-507. doi: 10.1002/env.891.

Spectral methods are powerful tools to study and model the dependency structure of spatial temporal processes. However, standard spectral approaches as well as geostatistical methods assume separability and stationarity of the covariance function; these can be very unrealistic assumptions...

Chemical composition and antigenotoxic properties of Lippia alba essential oils.

Genetics and molecular biology

López MA, Stashenko EE, Fuentes JL.
PMID: 21931523
Genet Mol Biol. 2011 Jul;34(3):479-88. doi: 10.1590/S1415-47572011005000030. Epub 2011 Jul 01.

The present work evaluated the chemical composition and the DNA protective effect of the essential oils (EOs) from Lippia alba against bleomycin-induced genotoxicity. EO constituents were determined by Gas Chromatography/Mass Spectrometric (GC-MS) analysis. The major compounds encountered being citral...

Showing 1 to 12 of 303 entries