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González-Fernández B, Sánchez DI, Crespo I, et al. Melatonin Attenuates Dysregulation of the Circadian Clock Pathway in Mice With CCl. Front Pharmacol. 2018;9:556doi: 10.3389/fphar.2018.00556.
González-Fernández, B., Sánchez, D. I., Crespo, I., San-Miguel, B., de Urbina, J. O., González-Gallego, J., & Tuñón, M. J. (2018). Melatonin Attenuates Dysregulation of the Circadian Clock Pathway in Mice With CCl. Frontiers in pharmacology, 9556. https://doi.org/10.3389/fphar.2018.00556
González-Fernández, Bárbara, et al. "Melatonin Attenuates Dysregulation of the Circadian Clock Pathway in Mice With CCl." Frontiers in pharmacology vol. 9 (2018): 556. doi: https://doi.org/10.3389/fphar.2018.00556
González-Fernández B, Sánchez DI, Crespo I, San-Miguel B, de Urbina JO, González-Gallego J, Tuñón MJ. Melatonin Attenuates Dysregulation of the Circadian Clock Pathway in Mice With CCl. Front Pharmacol. 2018 May 28;9:556. doi: 10.3389/fphar.2018.00556. eCollection 2018. PMID: 29892224; PMCID: PMC5985434.
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Front Pharmacol. 2018 May 28;9:556. doi: 10.3389/fphar.2018.00556. eCollection 2018.

Melatonin Attenuates Dysregulation of the Circadian Clock Pathway in Mice With CCl.

Frontiers in pharmacology

Bárbara González-Fernández, Diana I Sánchez, Irene Crespo, Beatriz San-Miguel, Juan Ortiz de Urbina, Javier González-Gallego, María J Tuñón

Affiliations

  1. Institute of Biomedicine (IBIOMED), University of León, León, Spain.
  2. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), León, Spain.
  3. Pharmacy Service, Complejo Asistencial Universitario de León, León, Spain.

PMID: 29892224 PMCID: PMC5985434 DOI: 10.3389/fphar.2018.00556

Abstract

Dysregulation of the circadian clock machinery is a critical mechanism in the pathogenesis of fibrosis. This study aimed to investigate whether the antifibrotic effect of melatonin is associated with attenuation of circadian clock pathway disturbances in mice treated with carbon tetrachloride (CCl

Keywords: SR9009; clock genes; hepatic stellate cells; liver fibrosis; melatonin

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