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Front Physiol. 2018 Jun 05;9:510. doi: 10.3389/fphys.2018.00510. eCollection 2018.

Inhibition of Small Conductance Calcium-Activated Potassium (SK) Channels Prevents Arrhythmias in Rat Atria During β-Adrenergic and Muscarinic Receptor Activation.

Frontiers in physiology

Lasse Skibsbye, Anne K Bengaard, A M Uldum-Nielsen, Kim Boddum, Torsten Christ, Thomas Jespersen

Affiliations

  1. Cardiac Physiology Laboratory, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  2. Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, DZHK: German Centre for Cardiovascular Research, Hamburg, Germany.

PMID: 29922167 PMCID: PMC5996028 DOI: 10.3389/fphys.2018.00510

Abstract

Sympathetic and vagal activation is linked to atrial arrhythmogenesis. Here we investigated the small conductance Ca

Keywords: SK channels; action potential recordings; atrial fibrillation; parasympathetic and sympathetic activation; β-adrenergic and muscarinic activation

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