Natl Med J India. 1990 Jan-Feb;3(1):17-19.
The National medical journal of India
S S Papiha, S S Bhattacharya
PMID: 29865128
We examined heterozygosity levels in Indian Muslims, Indian Hindus and Chinese for probes 754, XJl-I and pert 87.8 to determine whether the known X-linked probes close to the Duchenne muscular dystrophy gene varied in their usefulness in prenatal diagnosis. The probes 754 and pert 87.8 were highly polymorphic in Indians compared to the Chinese (754 allele 9-kb: Indians 19% to 26% v. Chinese 9%; and pert 87.8 allele 1.1- and 2.7-kb: 'Indians 42% to 58% v. Chinese 28%). However, the polymorphic information content for the XJ I-I probe was similar in both racial groups, Though the average heterozygosity for the three probes together is fairly similar in the racial groups (Indians 46%, Chinese 47%) their differences in allele frequency and heterozygosity are such that their use in combination may be equally informative.