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McGrath LA, Salvi SM, Sandramouli S, et al. Squamous cell carcinoma in the anophthalmic socket: a series of four cases with HPV-16 profiling. Br J Ophthalmol. 2018;doi: 10.1136/bjophthalmol-2018-311916.
McGrath, L. A., Salvi, S. M., Sandramouli, S., Bhatt, R., Cuschieri, K., & Mudhar, H. S. (2018). Squamous cell carcinoma in the anophthalmic socket: a series of four cases with HPV-16 profiling. The British journal of ophthalmology, . https://doi.org/10.1136/bjophthalmol-2018-311916
McGrath, Lindsay A, et al. "Squamous cell carcinoma in the anophthalmic socket: a series of four cases with HPV-16 profiling." The British journal of ophthalmology vol. (2018). doi: https://doi.org/10.1136/bjophthalmol-2018-311916
McGrath LA, Salvi SM, Sandramouli S, Bhatt R, Cuschieri K, Mudhar HS. Squamous cell carcinoma in the anophthalmic socket: a series of four cases with HPV-16 profiling. Br J Ophthalmol. 2018 Jun 28; doi: 10.1136/bjophthalmol-2018-311916. Epub 2018 Jun 28. PMID: 29954784.
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Br J Ophthalmol. 2018 Jun 28; doi: 10.1136/bjophthalmol-2018-311916. Epub 2018 Jun 28.

Squamous cell carcinoma in the anophthalmic socket: a series of four cases with HPV-16 profiling.

The British journal of ophthalmology

Lindsay A McGrath, Sachin Madhusudan Salvi, Soupramanien Sandramouli, Rina Bhatt, Kate Cuschieri, Hardeep Singh Mudhar

Affiliations

  1. University of Queensland School of Medicine, Brisbane, Queensland, Australia [email protected].
  2. Sheffield Ocular Oncology Service, Royal Hallamshire Hospital, Sheffield, UK.
  3. Wolverhampton and Midland Counties Eye Infirmary, Wolverhampton, UK.
  4. Department of Laboratory Medicine, Scottish HPV Reference Laboratory, Royal Infirmary of Edinburgh, Edinburgh, UK.
  5. Department of Histopathology, National Specialist Ophthalmic Pathology Service (NSOPS), Royal Hallamshire Hospital, Sheffield, UK.

PMID: 29954784 DOI: 10.1136/bjophthalmol-2018-311916

Abstract

PURPOSE: To present the clinical and histological features of squamous cell carcinoma (SCC) in the anophthalmic socket in four adult patients, and to determine the presence of human papillomavirus infection (HPV).

METHODS: Retrospective case series of four adult patients with SCC of the anophthalmic socket. P16 immunohistochemistry and HPV testing was carried out in all cases. The authors report clinical findings, histopathology, management and outcomes for all four patients with conjunctival SCC. Previously reported cases of conjunctival SCC in anophthalmic sockets were reviewed.

RESULTS: Four adult patients presented with eyelid lumps, discharge or change in prosthesis fit. Common examination findings included papillomatous changes, eyelid masses and epithelial changes. Three out of the four cases (75%) were positive for p16 by immunohistochemistry and the same cases positive for HPV-16 DNA. All patients received cryotherapy, topical or intralesional chemotherapy. Two patients proceeded to exenteration for control of invasive disease.

CONCLUSIONS: To the authors' knowledge, this is the largest series of SCC in the anophthalmic socket with comprehensive annotation of HPV status. Although socket conjunctiva is protected from environmental radiation, there is still a risk of neoplastic transformation in this tissue, thus patient education and regular checking of sockets by ophthalmologists should be undertaken as a preventative measure. The potential role of HPV in these tumours warrants further investigation.

© Author(s) (or their employer(s)) 2018. No commercial re-use. See rights and permissions. Published by BMJ.

Keywords: conjunctiva; diagnostic tests/investigation; neoplasia; ocular surface; orbit

Conflict of interest statement

Competing interests: None declared.

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