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Structural basis for potent antibody-mediated neutralization of human cytomegalovirus.

Science immunology

Chandramouli S, Malito E, Nguyen T, Luisi K, Donnarumma D, Xing Y, Norais N, Yu D, Carfi A.
PMID: 28783665
Sci Immunol. 2017 Jun 30;2(12). doi: 10.1126/sciimmunol.aan1457.

Human cytomegalovirus (HCMV) is the leading viral cause of birth defects and organ transplant rejection. The HCMV gH/gL/UL128/UL130/UL131A complex (Pentamer) is the main target of humoral responses and thus a key vaccine candidate. We report two structures of Pentamer...

Computer Extracted Features from Initial H&E Tissue Biopsies Predict Disease Progression for Prostate Cancer Patients on Active Surveillance.


Chandramouli S, Leo P, Lee G, Elliott R, Davis C, Zhu G, Fu P, Epstein JI, Veltri R, Madabhushi A.
PMID: 32967377
Cancers (Basel). 2020 Sep 21;12(9). doi: 10.3390/cancers12092708.

In this work, we assessed the ability of computerized features of nuclear morphology from diagnostic biopsy images to predict prostate cancer (CaP) progression in active surveillance (AS) patients. Improved risk characterization of AS patients could reduce over-testing of low-risk...

Improved epitope resolution of the prefusion trimer-specific antibody AM14 bound to the RSV F glycoprotein.


Harshbarger W, Abeyrathne PD, Tian S, Huang Y, Chandramouli S, Bottomley MJ, Malito E.
PMID: 34420474
MAbs. 2021 Jan-Dec;13(1):1955812. doi: 10.1080/19420862.2021.1955812.

Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory tract infections resulting in medical intervention and hospitalizations during infancy and early childhood, and vaccination against RSV remains a public health priority. The RSV F glycoprotein...

Computationally Derived Cribriform Area Index from Prostate Cancer Hematoxylin and Eosin Images Is Associated with Biochemical Recurrence Following Radical Prostatectomy and Is Most Prognostic in Gleason Grade Group 2.

European urology focus

Leo P, Chandramouli S, Farré X, Elliott R, Janowczyk A, Bera K, Fu P, Janaki N, El-Fahmawi A, Shahait M, Kim J, Lee D, Yamoah K, Rebbeck TR, Khani F, Robinson BD, Shih NNC, Feldman M, Gupta S, McKenney J, Lal P, Madabhushi A.
PMID: 33941504
Eur Urol Focus. 2021 Jul;7(4):722-732. doi: 10.1016/j.euf.2021.04.016. Epub 2021 Apr 30.

BACKGROUND: The presence of invasive cribriform adenocarcinoma (ICC), an expanse of cells containing punched-out lumina uninterrupted by stroma, in radical prostatectomy (RP) specimens has been associated with biochemical recurrence (BCR). However, ICC identification has only moderate inter-reviewer agreement.OBJECTIVE: To...

Molluscum Contagiosum-Induced Periocular Toxic Dermatitis.

Journal of pediatric ophthalmology and strabismus

Ghosh YK, Freeth M, Sandramouli S.
PMID: 19645390
J Pediatr Ophthalmol Strabismus. 2009 Jun 25; doi: 10.3928/01913913-20090616-03. Epub 2009 Jun 25.

This report describes an unusual case of a 9-year-old boy with a 6-month history of right lower eyelid lesion and excoriation of the adjoining skin that had not responded to topical treatment. The umbilicated lesion was electively excised and...

Sentinel node detection in endometrial cancer using indocyanine green and fluorescence imaging-a case report.


Rajanbabu A, Venkatesan R, Chandramouli S, Nitu PV.
PMID: 26180548
Ecancermedicalscience. 2015 Jun 29;9:549. doi: 10.3332/ecancer.2015.549. eCollection 2015.

Sentinel lymph node mapping in endometrial cancer can help to provide the prognostic information needed while avoiding the morbidity associated with a complete lymphadenectomy. Studies with blue dye and technetium colloid have only given about 80% detection rates whereas...

Squamous cell carcinoma in the anophthalmic socket: a series of four cases with HPV-16 profiling.

The British journal of ophthalmology

McGrath LA, Salvi SM, Sandramouli S, Bhatt R, Cuschieri K, Mudhar HS.
PMID: 29954784
Br J Ophthalmol. 2018 Jun 28; doi: 10.1136/bjophthalmol-2018-311916. Epub 2018 Jun 28.

PURPOSE: To present the clinical and histological features of squamous cell carcinoma (SCC) in the anophthalmic socket in four adult patients, and to determine the presence of human papillomavirus infection (HPV).METHODS: Retrospective case series of four adult patients with...

Efficacy of preoperative chemoradiotherapy in downstaging rectal cancer and its impact on the long-term outcome.

South Asian journal of cancer

Manur JG, Patel RB, Chandramouli S.
PMID: 31069187
South Asian J Cancer. 2019 Apr-Jun;8(2):98-101. doi: 10.4103/sajc.sajc_203_17.

INTRODUCTION: Response to preoperative chemoradiation (PRTCT) for rectal cancer predicts the long-term outcome.CONTEXT: Tertiary care hospital.AIMS: The aim is to study the factors affecting the response to chemoradiation.SETTINGS AND DESIGN: Retrospective.MATERIALS AND METHODS: Twenty-three patients of rectal cancer undergoing...

Oedipism: An unusual case of auto-enucleation including mechanism of avulsion.

European journal of ophthalmology

Okafor L, Choudry A, Mudhar HS, Sandramouli S.
PMID: 33183093
Eur J Ophthalmol. 2020 Nov 13;1120672120972028. doi: 10.1177/1120672120972028. Epub 2020 Nov 13.

INTRODUCTION: Self-inflicted enucleation, also known as auto-enucleation (AE) or Oedipism, is an uncommon and severe form of ocular injury which presents as an ophthalmic and psychiatric emergency. Usually known to occur with untreated psychosis, this case is a rare...

Indications and Outcome of Carotid Doppler Ultrasound An Ophthalmic Perspective.

European journal of ophthalmology

Mukherji S, Kurli M, Sandramouli S.
PMID: 28226174
Eur J Ophthalmol. 2004 May - Jun 2004;14(3):240-244. doi: 10.5301/EJO.2008.5664.

PURPOSE: The purpose of this study was to assess indications and outcome of carotid Doppler ultrasound requested by ophthalmologists from an eye hospital over a period of three years.METHODS: This retrospective study was designed to analyse data for all...

More Than a Rash: Recurrent Hepatocellular Carcinoma After Liver Transplantation.

ACG case reports journal

Moraveji S, Pedersen MR, Chandramouli S, Kerr TA, Grant LM.
PMID: 31620514
ACG Case Rep J. 2019 Jul 10;6(7):e00107. doi: 10.14309/crj.0000000000000107. eCollection 2019 Jul.

Recurrent hepatocellular carcinoma (HCC) after liver transplant is uncommon in patients who have favorable pretransplant characteristics. We present a 56-year-old man with a history of liver transplant 8 weeks prior for hepatitis C cirrhosis and HCC who presented for...

Novel Surrogate Neutralizing Assay Supports Parvovirus B19 Vaccine Development for Children with Sickle Cell Disease.


Penkert RR, Chandramouli S, Dormitzer PR, Settembre EC, Sealy RE, Wong S, Young NS, Sun Y, Tang L, Cotton A, Dowdy J, Hayden RT, Hankins JS, Hurwitz JL.
PMID: 34451986
Vaccines (Basel). 2021 Aug 04;9(8). doi: 10.3390/vaccines9080860.

Children with sickle cell disease (SCD) suffer life-threatening transient aplastic crisis (TAC) when infected with parvovirus B19. In utero, infection of healthy fetuses may result in anemia, hydrops, and death. Unfortunately, although promising vaccine candidates exist, no product has...

Showing 1 to 12 of 15 entries