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Ekoru K, Young EH, Dillon DG, et al. HIV treatment is associated with a two-fold higher probability of raised triglycerides: Pooled Analyses in 21 023 individuals in sub-Saharan Africa. Glob Health Epidemiol Genom. 2018;3doi: 10.1017/gheg.2018.7.
Ekoru, K., Young, E. H., Dillon, D. G., Gurdasani, D., Stehouwer, N., Faurholt-Jepsen, D., Levitt, N. S., Crowther, N. J., Nyirenda, M., Njelekela, M. A., Ramaiya, K., Nyan, O., Adewole, O. O., Anastos, K., Compostella, C., Dave, J. A., Fourie, C. M., Friis, H., Kruger, I. M., Longenecker, C. T., Maher, D. P., Mutimura, E., Ndhlovu, C. E., Praygod, G., Pefura Yone, E. W., Pujades-Rodriguez, M., Range, N., Sani, M. U., Sanusi, M., Schutte, A. E., Sliwa, K., Tien, P. C., Vorster, E. H., Walsh, C., Gareta, D., Mashili, F., Sobngwi, E., Adebamowo, C., Kamali, A., Seeley, J., Smeeth, L., Pillay, D., Motala, A. A., Kaleebu, P., & Sandhu, M. S. (2018). HIV treatment is associated with a two-fold higher probability of raised triglycerides: Pooled Analyses in 21 023 individuals in sub-Saharan Africa. Global health, epidemiology and genomics, 3. https://doi.org/10.1017/gheg.2018.7
Ekoru, Kenneth, et al. "HIV treatment is associated with a two-fold higher probability of raised triglycerides: Pooled Analyses in 21 023 individuals in sub-Saharan Africa." Global health, epidemiology and genomics vol. 3 (2018). doi: https://doi.org/10.1017/gheg.2018.7
Ekoru K, Young EH, Dillon DG, Gurdasani D, Stehouwer N, Faurholt-Jepsen D, Levitt NS, Crowther NJ, Nyirenda M, Njelekela MA, Ramaiya K, Nyan O, Adewole OO, Anastos K, Compostella C, Dave JA, Fourie CM, Friis H, Kruger IM, Longenecker CT, Maher DP, Mutimura E, Ndhlovu CE, Praygod G, Pefura Yone EW, Pujades-Rodriguez M, Range N, Sani MU, Sanusi M, Schutte AE, Sliwa K, Tien PC, Vorster EH, Walsh C, Gareta D, Mashili F, Sobngwi E, Adebamowo C, Kamali A, Seeley J, Smeeth L, Pillay D, Motala AA, Kaleebu P, Sandhu MS. HIV treatment is associated with a two-fold higher probability of raised triglycerides: Pooled Analyses in 21 023 individuals in sub-Saharan Africa. Glob Health Epidemiol Genom. 2018;3. doi: 10.1017/gheg.2018.7. Epub 2018 May 08. PMID: 29881632; PMCID: PMC5985947.
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Glob Health Epidemiol Genom. 2018;3. doi: 10.1017/gheg.2018.7. Epub 2018 May 08.

HIV treatment is associated with a two-fold higher probability of raised triglycerides: Pooled Analyses in 21 023 individuals in sub-Saharan Africa.

Global health, epidemiology and genomics

Kenneth Ekoru, Elizabeth H Young, David G Dillon, Deepti Gurdasani, Nathan Stehouwer, Daniel Faurholt-Jepsen, Naomi S Levitt, Nigel J Crowther, Moffat Nyirenda, Marina A Njelekela, Kaushik Ramaiya, Ousman Nyan, Olanisun O Adewole, Kathryn Anastos, Caterina Compostella, Joel A Dave, Carla M Fourie, Henrik Friis, Iolanthe M Kruger, Chris T Longenecker, Dermot P Maher, Eugene Mutimura, Chiratidzo E Ndhlovu, George Praygod, Eric W Pefura Yone, Mar Pujades-Rodriguez, Nyagosya Range, Mahmoud U Sani, Muhammad Sanusi, Aletta E Schutte, Karen Sliwa, Phyllis C Tien, Este H Vorster, Corinna Walsh, Dickman Gareta, Fredirick Mashili, Eugene Sobngwi, Clement Adebamowo, Anatoli Kamali, Janet Seeley, Liam Smeeth, Deenan Pillay, Ayesha A Motala, Pontiano Kaleebu, Manjinder S Sandhu

Affiliations

  1. Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
  2. Global Health and Populations Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.
  3. Weill Cornell Medical College, New York City, New York, USA.
  4. University Hospitals Case Medical Center, Cleveland, Ohio, USA.
  5. Department of Infectious Diseases, University of Copenhagen (Rigshospitalet), Copenhagen, Denmark.
  6. Division of Diabetic Medicine and Endocrinology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
  7. Department of Chemical Pathology, National Health Laboratory Service, University of the Witwatersrand Medical School, Johannesburg, South Africa.
  8. Malawi Epidemiology and Intervention Research Unit, Lilongwe, Malawi.
  9. Department of Physiology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
  10. Shree Hindu Mandal Hospital, Dar es Salaam, Tanzania.
  11. Royal Victoria Teaching Hospital, School of Medicine, University of The Gambia, Banjul, The Gambia.
  12. Department of Medicine, Obafemi Awolowo University, Ile Ife, Nigeria.
  13. Albert Einstein College of Medicine, Bronx NY USA.
  14. Department of Medicine, University of Padua, Padua, Italy.
  15. HART (Hypertension in Africa Research Team), North-West University, Potchefstroom, South Africa.
  16. Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Denmark.
  17. Africa Unit for Transdisciplinary Health Research (AUTHeR), North-West University, Potchefstroom, South Africa.
  18. Special Programme for Research & Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland.
  19. Clinical Epidemiology Resource Training Centre, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
  20. National Institute for Medical Research, Dar es Salaam, Tanzania.
  21. Chest Unit of Yaounde Jamot Hospital, Yaoundé, Cameroon.
  22. Epicentre, Médecins Sans Frontières, Paris, France.
  23. University College of London, Clinical Epidemiology Group, Department of Epidemiology and Public Health, London, United Kingdom.
  24. Cardiology Unit, Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria.
  25. MRC Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa.
  26. Soweto Cardiovascular Research Unit, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa.
  27. Department of Medicine, University of California, San Francisco, United States of America.
  28. Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
  29. Department of Nutrition and Dietetics, University of the Free State, Bloemfontein, South Africa.
  30. Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
  31. Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.
  32. Institute of Human Virology, Abuja, Nigeria.
  33. Department of Epidemiology and Public Health, Institute of Human Virology and Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, United States of America.
  34. MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda.
  35. Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
  36. Department of Diabetes and Endocrinology, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.

PMID: 29881632 PMCID: PMC5985947 DOI: 10.1017/gheg.2018.7

Abstract

BACKGROUND: Anti-retroviral therapy (ART) regimes for HIV are associated with raised levels of circulating triglycerides (TG) in western populations. However, there are limited data on the impact of ART on cardiometabolic risk in sub-Saharan African (SSA) populations.

METHODS: Pooled analyses of 14 studies comprising 21 023 individuals, on whom relevant cardiometabolic risk factors (including TG), HIV and ART status were assessed between 2003 and 2014, in SSA. The association between ART and raised TG (>2.3 mmol/L) was analysed using regression models.

FINDINGS: Among 10 615 individuals, ART was associated with a two-fold higher probability of raised TG (RR 2.05, 95% CI 1.51-2.77, I

INTERPRETATION: Evidence from this study confirms the association of ART with raised TG in SSA populations. Given the possible causal effect of raised TG on cardiovascular disease (CVD), the evidence highlights the need for prospective studies to clarify the impact of long term ART on CVD outcomes in SSA.

Keywords: Antiretroviral therapy; Cardiovascular disease; HIV; Lipids; Sub-Saharan Africa; Triglycerides

Conflict of interest statement

Conflict of interest The authors declare no conflict of interest.

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