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Wang JN, Li L, Li LY, et al. Emerging role and therapeutic implication of Wnt signaling pathways in liver fibrosis. Gene. 2018;674:57-69doi: 10.1016/j.gene.2018.06.053.
Wang, J. N., Li, L., Li, L. Y., Yan, Q., Li, J., & Xu, T. (2018). Emerging role and therapeutic implication of Wnt signaling pathways in liver fibrosis. Gene, 67457-69. https://doi.org/10.1016/j.gene.2018.06.053
Wang, Ji-Nian, et al. "Emerging role and therapeutic implication of Wnt signaling pathways in liver fibrosis." Gene vol. 674 (2018): 57-69. doi: https://doi.org/10.1016/j.gene.2018.06.053
Wang JN, Li L, Li LY, Yan Q, Li J, Xu T. Emerging role and therapeutic implication of Wnt signaling pathways in liver fibrosis. Gene. 2018 Oct 20;674:57-69. doi: 10.1016/j.gene.2018.06.053. Epub 2018 Jun 23. PMID: 29944952.
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Gene. 2018 Oct 20;674:57-69. doi: 10.1016/j.gene.2018.06.053. Epub 2018 Jun 23.

Emerging role and therapeutic implication of Wnt signaling pathways in liver fibrosis.

Gene

Ji-Nian Wang, Li Li, Liang-Yun Li, Qi Yan, Jun Li, Tao Xu

Affiliations

  1. Department of Education, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei, 230022, Anhui Province, China.
  2. Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, China.
  3. School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University, Anhui Medical University, Hefei 230032, China.
  4. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
  5. School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University, Anhui Medical University, Hefei 230032, China. Electronic address: [email protected].

PMID: 29944952 DOI: 10.1016/j.gene.2018.06.053

Abstract

Activation of hepatic stellate cells (HSCs) is a pivotal cellular event in liver fibrosis. Therefore, improving our understanding of the molecular pathways that are involved in these processes is essential to generate new therapies for liver fibrosis. Greater knowledge of the role of the Wnt signaling pathway in liver fibrosis could improve understanding of the liver fibrosis pathogenesis. The aim of this review is to describe the present knowledge about the Wnt signaling pathway, which significantly participates in liver fibrosis and HSC activation, and look ahead on new perspectives of Wnt signaling pathway research. Moreover, we will discuss the different interactions with Wnt signaling pathway-regulated liver fibrosis. The Wnt signaling pathway modulates several important aspects of function, including cell proliferation, activation and differentiation. Targeting the Wnt signaling pathway can be a promising direction in liver fibrosis treatment. We discuss new perspectives of Wnt signaling pathway activation in liver fibrosis. For example, antagonist to Wnt and Wnt ligands could inhibit liver fibrosis by regulating Wnt/β-catenin signaling pathway. These findings identify the Wnt signaling pathway as a potentially important for therapeutic targets in liver fibrosis. Future studies are needed in order to find safer and more effective Wnt-based drugs.

Copyright © 2018 Elsevier B.V. All rights reserved.

Keywords: Canonical Wnt signaling pathway; Hepatic stellate cell; Liver fibrosis; Wnt signaling

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