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Wang T, Wu KY, Miner RC, et al. Reproducible quantification of cardiac sympathetic innervation using graphical modeling of carbon-11-meta-hydroxyephedrine kinetics with dynamic PET-CT imaging. EJNMMI Res. 2018;8(1):63doi: 10.1186/s13550-018-0421-5.
Wang, T., Wu, K. Y., Miner, R. C., Renaud, J. M., Beanlands, R. S. B., & deKemp, R. A. (2018). Reproducible quantification of cardiac sympathetic innervation using graphical modeling of carbon-11-meta-hydroxyephedrine kinetics with dynamic PET-CT imaging. EJNMMI research, 8(1), 63. https://doi.org/10.1186/s13550-018-0421-5
Wang, Tong, et al. "Reproducible quantification of cardiac sympathetic innervation using graphical modeling of carbon-11-meta-hydroxyephedrine kinetics with dynamic PET-CT imaging." EJNMMI research vol. 8,1 (2018): 63. doi: https://doi.org/10.1186/s13550-018-0421-5
Wang T, Wu KY, Miner RC, Renaud JM, Beanlands RSB, deKemp RA. Reproducible quantification of cardiac sympathetic innervation using graphical modeling of carbon-11-meta-hydroxyephedrine kinetics with dynamic PET-CT imaging. EJNMMI Res. 2018 Jul 20;8(1):63. doi: 10.1186/s13550-018-0421-5. PMID: 30030665; PMCID: PMC6054601.
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EJNMMI Res. 2018 Jul 20;8(1):63. doi: 10.1186/s13550-018-0421-5.

Reproducible quantification of cardiac sympathetic innervation using graphical modeling of carbon-11-meta-hydroxyephedrine kinetics with dynamic PET-CT imaging.

EJNMMI research

Tong Wang, Kai Yi Wu, Robert C Miner, Jennifer M Renaud, Rob S B Beanlands, Robert A deKemp

Affiliations

  1. National Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, K1Y 4W7, Canada.
  2. Department of Physiology, University of Toronto, 1 Kings College Circle, Toronto, ON, M5S 1A8, Canada.
  3. National Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, K1Y 4W7, Canada. [email protected].

PMID: 30030665 PMCID: PMC6054601 DOI: 10.1186/s13550-018-0421-5

Abstract

BACKGROUND: Graphical methods of radiotracer kinetic modeling in PET are ideal for parametric imaging and data quality assurance but can suffer from noise bias. This study compared the Logan and Multilinear Analysis-1 (MA1) graphical models to the standard one-tissue-compartment (1TC) model, including correction for partial-volume effects, in dynamic PET-CT studies of myocardial sympathetic innervation in the left ventricle (LV) using [

METHODS: Test and retest [

RESULTS: A modeling start-time of t* = 5 min gave the best fit for both Logan and MA1 (R

CONCLUSIONS: Logan and MA1 models exhibited similar agreement and variability compared to the 1TC for modeling of [

Keywords: HED; Logan; MA1; One tissue compartment; Sympathetic nervous system

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