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Eugenio M, Campanati L, Müller N, et al. Silver/silver chloride nanoparticles inhibit the proliferation of human glioblastoma cells. Cytotechnology. 2018;70(6):1607-1618doi: 10.1007/s10616-018-0253-1.
Eugenio, M., Campanati, L., Müller, N., Romão, L. F., de Souza, J., Alves-Leon, S., de Souza, W., & Sant'Anna, C. (2018). Silver/silver chloride nanoparticles inhibit the proliferation of human glioblastoma cells. Cytotechnology, 70(6), 1607-1618. https://doi.org/10.1007/s10616-018-0253-1
Eugenio, Mateus, et al. "Silver/silver chloride nanoparticles inhibit the proliferation of human glioblastoma cells." Cytotechnology vol. 70,6 (2018): 1607-1618. doi: https://doi.org/10.1007/s10616-018-0253-1
Eugenio M, Campanati L, Müller N, Romão LF, de Souza J, Alves-Leon S, de Souza W, Sant'Anna C. Silver/silver chloride nanoparticles inhibit the proliferation of human glioblastoma cells. Cytotechnology. 2018 Dec;70(6):1607-1618. doi: 10.1007/s10616-018-0253-1. Epub 2018 Sep 10. PMID: 30203320; PMCID: PMC6269367.
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Cytotechnology. 2018 Dec;70(6):1607-1618. doi: 10.1007/s10616-018-0253-1. Epub 2018 Sep 10.

Silver/silver chloride nanoparticles inhibit the proliferation of human glioblastoma cells.

Cytotechnology

Mateus Eugenio, Loraine Campanati, Nathalia Müller, Luciana F Romão, Jorge de Souza, Soniza Alves-Leon, Wanderley de Souza, Celso Sant'Anna

Affiliations

  1. Laboratory of Microscopy Applied to Life Science - Lamav, National Institute of Metrology, Quality and Technology - Inmetro, Av. Nossa Senhora das Graças, 50, prédio 27- Xerém, Duque de Caxias, RJ, 25250-020, Brazil.
  2. Post-Graduation Program on Translational Biomedicine - Biotrans, Duque de Caxias, Rio de Janeiro, Brazil.
  3. Laboratory of Cellular Morphogenesis, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  4. Biomedical Science, Federal University of Rio de Janeiro, Xerém, Duque de Caxias, RJ, Brazil.
  5. University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  6. National Institute of Science and Technology for Structural Biology and Bioimaging, Rio de Janeiro, RJ, Brazil.
  7. Laboratory of Cellular Ultrastructure Hertha Meyer, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  8. Laboratory of Microscopy Applied to Life Science - Lamav, National Institute of Metrology, Quality and Technology - Inmetro, Av. Nossa Senhora das Graças, 50, prédio 27- Xerém, Duque de Caxias, RJ, 25250-020, Brazil. [email protected].
  9. Post-Graduation Program on Translational Biomedicine - Biotrans, Duque de Caxias, Rio de Janeiro, Brazil. [email protected].
  10. National Institute of Science and Technology for Structural Biology and Bioimaging, Rio de Janeiro, RJ, Brazil. [email protected].

PMID: 30203320 PMCID: PMC6269367 DOI: 10.1007/s10616-018-0253-1

Abstract

Glioblastomas (GBM) are aggressive brain tumors with very poor prognosis. While silver nanoparticles represent a potential new strategy for anticancer therapy, the silver/silver chloride nanoparticles (Ag/AgCl-NPs) have microbicidal activity, but had not been tested against tumor cells. Here, we analyzed the effect of biogenically produced Ag/AgCl-NPs (from yeast cultures) on the proliferation of GBM02 glioblastoma cells (and of human astrocytes) by automated, image-based high-content analysis (HCA). We compared the effect of 0.1-5.0 µg mL

Keywords: Antiproliferative effect; Cancer; Glioblastoma; High-content analysis; Metallic nanoparticles; Silver/silver chloride nanoparticles

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