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Singh ZN, Duong VH, Koka R, et al. High-Risk Acute Promyelocytic Leukemia with Unusual T/Myeloid Immunophenotype Successfully Treated with ATRA and Arsenic Trioxide-Based Regimen. J Hematop. 2018;11(3):67-74doi: 10.1007/s12308-018-0329-z.
Singh, Z. N., Duong, V. H., Koka, R., Zou, Y., Sawhney, S., Tang, L., Baer, M. R., Ambulos, N., El Chaer, F., & Emadi, A. (2018). High-Risk Acute Promyelocytic Leukemia with Unusual T/Myeloid Immunophenotype Successfully Treated with ATRA and Arsenic Trioxide-Based Regimen. Journal of hematopathology, 11(3), 67-74. https://doi.org/10.1007/s12308-018-0329-z
Singh, Zeba N, et al. "High-Risk Acute Promyelocytic Leukemia with Unusual T/Myeloid Immunophenotype Successfully Treated with ATRA and Arsenic Trioxide-Based Regimen." Journal of hematopathology vol. 11,3 (2018): 67-74. doi: https://doi.org/10.1007/s12308-018-0329-z
Singh ZN, Duong VH, Koka R, Zou Y, Sawhney S, Tang L, Baer MR, Ambulos N, El Chaer F, Emadi A. High-Risk Acute Promyelocytic Leukemia with Unusual T/Myeloid Immunophenotype Successfully Treated with ATRA and Arsenic Trioxide-Based Regimen. J Hematop. 2018 Sep;11(3):67-74. doi: 10.1007/s12308-018-0329-z. Epub 2018 Aug 09. PMID: 30294391; PMCID: PMC6171103.
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J Hematop. 2018 Sep;11(3):67-74. doi: 10.1007/s12308-018-0329-z. Epub 2018 Aug 09.

High-Risk Acute Promyelocytic Leukemia with Unusual T/Myeloid Immunophenotype Successfully Treated with ATRA and Arsenic Trioxide-Based Regimen.

Journal of hematopathology

Zeba N Singh, Vu H Duong, Rima Koka, Ying Zou, Sameer Sawhney, Li Tang, Maria R Baer, Nicholas Ambulos, Firas El Chaer, Ashkan Emadi

Affiliations

  1. Department of Pathology, University of Maryland School of Medicine.
  2. Department of Medicine, University of Maryland School of Medicine.
  3. University of Maryland Greenebaum Comprehensive Cancer Center Baltimore, MD, USA.
  4. Department of Pharmacology, University of Maryland School of Medicine.

PMID: 30294391 PMCID: PMC6171103 DOI: 10.1007/s12308-018-0329-z

Abstract

We describe two patients with acute promyelocytic leukemia (APL) with an unusual immunophenotype with co-expression of myeloperoxidase (MPO) with cytoplasmic CD3 (cCD3) representing myeloid and T-lineage differentiation. Both harbored

Keywords: acute promyelocytic leukemia (APL); all-trans retinoic acid (ATRA); arsenic trioxide (ATO); measurable (minimal) residual disease (MRD); mixed phenotype acute leukemia (MPAL)

Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

References

  1. Blood. 2015 Apr 16;125(16):2477-85 - PubMed
  2. Ann Hematol. 2014 Dec;93(12):2001-10 - PubMed
  3. Cancer Genet. 2012 Oct;205(10):537-40 - PubMed
  4. Cancer Genet Cytogenet. 2010 Dec;203(2):278-83 - PubMed
  5. Exp Hematol. 2016 Aug;44(8):740-4 - PubMed
  6. Haematologica. 2012 Nov;97(11):1708-12 - PubMed
  7. Am J Hematol. 2010 Dec;85(12):956-7 - PubMed
  8. Blood. 2007 Nov 15;110(10):3706-14 - PubMed
  9. Blood. 2012 Aug 23;120(8):1570-80; quiz 1752 - PubMed
  10. Am J Clin Pathol. 2011 Jan;135(1):76-84 - PubMed
  11. Br J Haematol. 1998 Sep;102(4):1035-41 - PubMed
  12. Blood. 2016 May 19;127(20):2391-405 - PubMed
  13. Genes Chromosomes Cancer. 2010 May;49(5):471-9 - PubMed
  14. Leukemia. 2016 Oct;30(10):1987-1992 - PubMed
  15. Blood. 2006 Nov 15;108(10):3484-93 - PubMed
  16. Leuk Res. 2015 Apr;39(4):397-9 - PubMed
  17. Blood. 2011 Mar 17;117(11):3163-71 - PubMed
  18. Leukemia. 2002 Nov;16(11):2185-9 - PubMed
  19. Cancer Genet. 2014 Jan-Feb;207(1-2):48-9 - PubMed
  20. Leukemia. 1995 Oct;9(10):1783-6 - PubMed
  21. Haematologica. 2011 Oct;96(10):1470-7 - PubMed
  22. Br J Haematol. 1991 Aug;78(4):494-9 - PubMed
  23. Best Pract Res Clin Haematol. 2003 Sep;16(3):369-85 - PubMed
  24. Biol Blood Marrow Transplant. 2016 Jun;22(6):1024-1029 - PubMed
  25. Leuk Lymphoma. 2014 Jul;55(7):1523-32 - PubMed
  26. Haematologica. 1999 May;84(5):405-12 - PubMed
  27. Blood. 1992 Jul 15;80(2):492-7 - PubMed
  28. Blood. 1985 Jan;65(1):107-14 - PubMed
  29. Leukemia. 2005 Jul;19(7):1153-60 - PubMed
  30. Am J Clin Pathol. 2013 Jun;139(6):829 - PubMed
  31. Leukemia. 2003 Dec;17(12):2318-57 - PubMed
  32. Leuk Res. 2015 Feb;39(2):131-7 - PubMed
  33. Leuk Res. 2007 Feb;31(2):239-43 - PubMed
  34. Cancer Genet Cytogenet. 2003 Sep;145(2):144-51 - PubMed
  35. Acta Haematol. 2011;125(4):210-8 - PubMed
  36. Lancet Oncol. 2015 Oct;16(13):1295-305 - PubMed
  37. Nature. 1995 Jun 29;375(6534):795-8 - PubMed
  38. Leukemia. 1994 Jul;8(7):1108-12 - PubMed
  39. N Engl J Med. 2013 Jul 11;369(2):111-21 - PubMed
  40. Cancer Genet Cytogenet. 2009 Jan 15;188(2):103-7 - PubMed

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