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Amdursky N, Mazo MM, Thomas MR, et al. Elastic serum-albumin based hydrogels: mechanism of formation and application in cardiac tissue engineering. J Mater Chem B. 2018;6(35):5604-5612doi: 10.1039/C8TB01014E.
Amdursky, N., Mazo, M. M., Thomas, M. R., Humphrey, E. J., Puetzer, J. L., St-Pierre, J. P., Skaalure, S. C., Richardson, R. M., Terracciano, C. M., & Stevens, M. M. (2018). Elastic serum-albumin based hydrogels: mechanism of formation and application in cardiac tissue engineering. Journal of materials chemistry. B, 6(35), 5604-5612. https://doi.org/10.1039/C8TB01014E
Amdursky, Nadav, et al. "Elastic serum-albumin based hydrogels: mechanism of formation and application in cardiac tissue engineering." Journal of materials chemistry. B vol. 6,35 (2018): 5604-5612. doi: https://doi.org/10.1039/C8TB01014E
Amdursky N, Mazo MM, Thomas MR, Humphrey EJ, Puetzer JL, St-Pierre JP, Skaalure SC, Richardson RM, Terracciano CM, Stevens MM. Elastic serum-albumin based hydrogels: mechanism of formation and application in cardiac tissue engineering. J Mater Chem B. 2018 Sep 21;6(35):5604-5612. doi: 10.1039/C8TB01014E. Epub 2018 Aug 23. PMID: 30283632; PMCID: PMC6166857.
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J Mater Chem B. 2018 Sep 21;6(35):5604-5612. doi: 10.1039/C8TB01014E. Epub 2018 Aug 23.

Elastic serum-albumin based hydrogels: mechanism of formation and application in cardiac tissue engineering.

Journal of materials chemistry. B

Nadav Amdursky, Manuel M Mazo, Michael R Thomas, Eleanor J Humphrey, Jennifer L Puetzer, Jean-Philippe St-Pierre, Stacey C Skaalure, Robert M Richardson, Cesare M Terracciano, Molly M Stevens

Affiliations

  1. Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College Lodon, London, SW7 2AZ, UK.
  2. National Heart and Lung Institute, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London, SW7 2AZ, UK.
  3. H H Wills Physics Laboratory, University of Bristol, Bristol, BS8 1TL, UK.

PMID: 30283632 PMCID: PMC6166857 DOI: 10.1039/C8TB01014E

Abstract

Hydrogels are promising materials for mimicking the extra-cellular environment. Here, we present a simple methodology for the formation of a free-standing viscoelastic hydrogel from the abundant and low cost protein serum albumin. We show that the mechanical properties of the hydrogel exhibit a complicated behaviour as a function of the weight fraction of the protein component. We further use X-ray scattering to shed light on the mechanism of gelation from the formation of a fibrillary network at low weight fractions to interconnected aggregates at higher weight fractions. Given the match between our hydrogel elasticity and that of the myocardium, we investigated its potential for supporting cardiac cells

Conflict of interest statement

Conflicts of interest There are no conflicts to declare.

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