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Hanson HA, Hay WW, Tobin JN, et al. Opportunities for life course research through the integration of data across Clinical and Translational Research Institutes. J Clin Transl Sci. 2018;2(3):156-162doi: 10.1017/cts.2018.29.
Hanson, H. A., Hay, W. W., Tobin, J. N., Barkin, S. L., Atkins, M., Karagas, M. R., Dozier, A. M., Wetmore, C., Konstan, M. W., & Heubi, J. E. (2018). Opportunities for life course research through the integration of data across Clinical and Translational Research Institutes. Journal of clinical and translational science, 2(3), 156-162. https://doi.org/10.1017/cts.2018.29
Hanson, Heidi A, et al. "Opportunities for life course research through the integration of data across Clinical and Translational Research Institutes." Journal of clinical and translational science vol. 2,3 (2018): 156-162. doi: https://doi.org/10.1017/cts.2018.29
Hanson HA, Hay WW, Tobin JN, Barkin SL, Atkins M, Karagas MR, Dozier AM, Wetmore C, Konstan MW, Heubi JE. Opportunities for life course research through the integration of data across Clinical and Translational Research Institutes. J Clin Transl Sci. 2018 Jun;2(3):156-162. doi: 10.1017/cts.2018.29. PMID: 30370067; PMCID: PMC6202009.
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J Clin Transl Sci. 2018 Jun;2(3):156-162. doi: 10.1017/cts.2018.29.

Opportunities for life course research through the integration of data across Clinical and Translational Research Institutes.

Journal of clinical and translational science

Heidi A Hanson, William W Hay, Jonathan N Tobin, Shari L Barkin, Mark Atkins, Margaret R Karagas, Ann M Dozier, Cynthia Wetmore, Michael W Konstan, James E Heubi

Affiliations

  1. Department of Surgery, University of Utah School of Medicine, Population Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  2. Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.
  3. The Rockefeller University Center for Clinical and Translational Science and Clinical Directors Network (CDN), New York, NY, USA.
  4. Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
  5. Department of Psychiatry, Institute for Juvenile Research, The University of Illinois at Chicago, Chicago, IL, USA.
  6. Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
  7. Department of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, USA.
  8. Department of Pediatrics, Emory University, Children's Health Care of Atlanta, Atlanta, GA, USA.
  9. Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  10. Division of Gastroenterology, Pediatric Liver Care Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

PMID: 30370067 PMCID: PMC6202009 DOI: 10.1017/cts.2018.29

Abstract

INTRODUCTION: Early life exposures affect health and disease across the life course and potentially across multiple generations. The Clinical and Translational Research Institutes (CTSIs) offer an opportunity to utilize and link existing databases to conduct lifespan research.

METHODS: A survey with Lifespan Domain Taskforce expert input was created and distributed to lead lifespan researchers at each of the 64 CTSIs. The survey requested information regarding institutional databases related to early life exposure, child-maternal health, or lifespan research.

RESULTS: Of 64 CTSI, 88% provided information on a total of 130 databases. Approximately 59% (n=76/130) had an associated biorepository. Longitudinal data were available for 72% (n=93/130) of reported databases. Many of the biorepositories (n=44/76; 68%) have standard operating procedures that can be shared with other researchers.

CONCLUSIONS: The majority of CTSI databases and biorepositories focusing on child-maternal health and lifespan research could be leveraged for lifespan research, increased generalizability and enhanced multi-institutional research in the United States.

Keywords: Early life exposure; biorepository; clinical and translational science; life course; lifespan

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