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Mahinrad S, Bulk M, van der Velpen I, et al. Natriuretic Peptides in Post-mortem Brain Tissue and Cerebrospinal Fluid of Non-demented Humans and Alzheimer's Disease Patients. Front Neurosci. 2018;12:864doi: 10.3389/fnins.2018.00864.
Mahinrad, S., Bulk, M., van der Velpen, I., Mahfouz, A., van Roon-Mom, W., Fedarko, N., Yasar, S., Sabayan, B., van Heemst, D., & van der Weerd, L. (2018). Natriuretic Peptides in Post-mortem Brain Tissue and Cerebrospinal Fluid of Non-demented Humans and Alzheimer's Disease Patients. Frontiers in neuroscience, 12864. https://doi.org/10.3389/fnins.2018.00864
Mahinrad, Simin, et al. "Natriuretic Peptides in Post-mortem Brain Tissue and Cerebrospinal Fluid of Non-demented Humans and Alzheimer's Disease Patients." Frontiers in neuroscience vol. 12 (2018): 864. doi: https://doi.org/10.3389/fnins.2018.00864
Mahinrad S, Bulk M, van der Velpen I, Mahfouz A, van Roon-Mom W, Fedarko N, Yasar S, Sabayan B, van Heemst D, van der Weerd L. Natriuretic Peptides in Post-mortem Brain Tissue and Cerebrospinal Fluid of Non-demented Humans and Alzheimer's Disease Patients. Front Neurosci. 2018 Nov 26;12:864. doi: 10.3389/fnins.2018.00864. eCollection 2018. PMID: 30534047; PMCID: PMC6275179.
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Front Neurosci. 2018 Nov 26;12:864. doi: 10.3389/fnins.2018.00864. eCollection 2018.

Natriuretic Peptides in Post-mortem Brain Tissue and Cerebrospinal Fluid of Non-demented Humans and Alzheimer's Disease Patients.

Frontiers in neuroscience

Simin Mahinrad, Marjolein Bulk, Isabelle van der Velpen, Ahmed Mahfouz, Willeke van Roon-Mom, Neal Fedarko, Sevil Yasar, Behnam Sabayan, Diana van Heemst, Louise van der Weerd

Affiliations

  1. Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands.
  2. Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
  3. Department of Radiology, Leiden University Medical Center, Leiden, Netherlands.
  4. Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
  5. Percuros BV, Leiden, Netherlands.
  6. Leiden Computational Biology Center, Leiden University Medical Center, Leiden, Netherlands.
  7. Delft Bioinformatics Lab, Delft University of Technology, Delft, Netherlands.
  8. Clinical Research Core Laboratory, Johns Hopkins Institute for Clinical and Translational Research, Baltimore, MD, United States.
  9. Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, United States.

PMID: 30534047 PMCID: PMC6275179 DOI: 10.3389/fnins.2018.00864

Abstract

Animal studies suggest the involvement of natriuretic peptides (NP) in several brain functions that are known to be disturbed during Alzheimer's disease (AD). However, it remains unclear whether such findings extend to humans. In this study, we aimed to: (1) map the gene expression and localization of NP and their receptors (NPR) in human post-mortem brain tissue; (2) compare the relative amounts of NP and NPR between the brain tissue of AD patients and non-demented controls, and (3) compare the relative amounts of NP between the cerebrospinal fluid (CSF) of AD patients and non-demented controls. Using the publicly available Allen Human Brain Atlas dataset, we mapped the gene expression of NP and NPR in healthy humans. Using immunohistochemistry, we visualized the localization of NP and NPR in the frontal cortex of AD patients (

Keywords: Alzheimer disease; brain; cerebrospinal fluid; gene expression; humans; natriuretic peptides

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