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Showing 1 to 12 of 65 entries
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A simple and versatile method for frequent 24 h blood sample collection in healthy older adults.

MethodsX

Akintola AA, Jansen SW, Wilde RB, Hultzer G, Rodenburg R, van Heemst D.
PMID: 26150969
MethodsX. 2014 Dec 26;2:33-8. doi: 10.1016/j.mex.2014.12.003. eCollection 2015.

Repeated 24 h blood sampling, which is required for time series analyses of metabolites and/or hormones that show strong fluctuations in blood concentration over time, has a higher failure rate in older adults. We tailored existing venipuncture protocols toward...

Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age.

Frontiers in aging neuroscience

Akintola AA, van den Berg A, van Buchem MA, Jansen SW, Slagboom EP, Westendorp RG, van der Grond J, van Heemst D.
PMID: 26074813
Front Aging Neurosci. 2015 May 28;7:92. doi: 10.3389/fnagi.2015.00092. eCollection 2015.

Impaired glucose metabolism and type 2 diabetes have been associated with cognitive decline, dementia, and with structural and functional brain features. However, it is unclear whether these associations differ in individuals that differ in familial longevity or age. Here,...

Magnetophoretic Conductors and Diodes in a 3D Magnetic Field.

Advanced functional materials

Abedini-Nassab R, Joh DY, Van Heest M, Baker C, Chilkoti A, Murdoch DM, Yellen BB.
PMID: 27418922
Adv Funct Mater. 2016 Jun 14;26(22):4026-4034. doi: 10.1002/adfm.201503898. Epub 2015 Dec 07.

We demonstrate magnetophoretic conductor tracks that can transport single magnetized beads and magnetically labeled single cells in a 3-dimensional time-varying magnetic field. The vertical field bias, in addition to the in-plane rotating field, has the advantage of reducing the...

Impact of age, sex and body mass index on cortisol secretion in 143 healthy adults.

Endocrine connections

Roelfsema F, van Heemst D, Iranmanesh A, Takahashi P, Yang R, Veldhuis JD.
PMID: 28760748
Endocr Connect. 2017 Oct;6(7):500-509. doi: 10.1530/EC-17-0160. Epub 2017 Jul 31.

CONTEXT: Studies on 24-h cortisol secretion are rare. The impact of sex, age and adiposity on cortisol levels, often restricted to one or a few samples, are well recognized, but conflicting.OBJECTIVE: To investigate cortisol dynamics in 143 healthy men...

Gerontology and geriatrics in Dutch medical education.

The Netherlands journal of medicine

Tersmette W, van Bodegom D, van Heemst D, Stott D, Westendorp R.
PMID: 23956319
Neth J Med. 2013 Jul-Aug;71(6):331-7.

BACKGROUND: The world population is ageing and healthcare services require trained staff who can address the needs of older patients. In this study we determined how current medical education prepares Dutch students of medicine in the field of Gerontology...

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.

Molecular psychiatry

Wang H, Noordam R, Cade BE, Schwander K, Winkler TW, Lee J, Sung YJ, Bentley AR, Manning AK, Aschard H, Kilpeläinen TO, Ilkov M, Brown MR, Horimoto AR, Richard M, Bartz TM, Vojinovic D, Lim E, Nierenberg JL, Liu Y, Chitrala K, Rankinen T, Musani SK, Franceschini N, Rauramaa R, Alver M, Zee PC, Harris SE, van der Most PJ, Nolte IM, Munroe PB, Palmer ND, Kühnel B, Weiss S, Wen W, Hall KA, Lyytikäinen LP, O'Connell J, Eiriksdottir G, Launer LJ, de Vries PS, Arking DE, Chen H, Boerwinkle E, Krieger JE, Schreiner PJ, Sidney S, Shikany JM, Rice K, Chen YI, Gharib SA, Bis JC, Luik AI, Ikram MA, Uitterlinden AG, Amin N, Xu H, Levy D, He J, Lohman KK, Zonderman AB, Rice TK, Sims M, Wilson G, Sofer T, Rich SS, Palmas W, Yao J, Guo X, Rotter JI, Biermasz NR, Mook-Kanamori DO, Martin LW, Barac A, Wallace RB, Gottlieb DJ, Komulainen P, Heikkinen S, Mägi R, Milani L, Metspalu A, Starr JM, Milaneschi Y, Waken RJ, Gao C, Waldenberger M, Peters A, Strauch K, Meitinger T, Roenneberg T, Völker U, Dörr M, Shu XO, Mukherjee S, Hillman DR, Kähönen M, Wagenknecht LE, Gieger C, Grabe HJ, Zheng W, Palmer LJ, Lehtimäki T, Gudnason V, Morrison AC, Pereira AC, Fornage M, Psaty BM, van Duijn CM, Liu CT, Kelly TN, Evans MK, Bouchard C, Fox ER, Kooperberg C, Zhu X, Lakka TA, Esko T, North KE, Deary IJ, Snieder H, Penninx BWJH, Gauderman WJ, Rao DC, Redline S, van Heemst D.
PMID: 33859359
Mol Psychiatry. 2021 Nov;26(11):6293-6304. doi: 10.1038/s41380-021-01087-0. Epub 2021 Apr 15.

Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we performed genome-wide...

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.

Molecular psychiatry

Wang H, Noordam R, Cade BE, Schwander K, Winkler TW, Lee J, Sung YJ, Bentley AR, Manning AK, Aschard H, Kilpeläinen TO, Ilkov M, Brown MR, Horimoto AR, Richard M, Bartz TM, Vojinovic D, Lim E, Nierenberg JL, Liu Y, Chitrala K, Rankinen T, Musani SK, Franceschini N, Rauramaa R, Alver M, Zee PC, Harris SE, van der Most PJ, Nolte IM, Munroe PB, Palmer ND, Kühnel B, Weiss S, Wen W, Hall KA, Lyytikäinen LP, O'Connell J, Eiriksdottir G, Launer LJ, de Vries PS, Arking DE, Chen H, Boerwinkle E, Krieger JE, Schreiner PJ, Sidney S, Shikany JM, Rice K, Chen YI, Gharib SA, Bis JC, Luik AI, Ikram MA, Uitterlinden AG, Amin N, Xu H, Levy D, He J, Lohman KK, Zonderman AB, Rice TK, Sims M, Wilson G, Sofer T, Rich SS, Palmas W, Yao J, Guo X, Rotter JI, Biermasz NR, Mook-Kanamori DO, Martin LW, Barac A, Wallace RB, Gottlieb DJ, Komulainen P, Heikkinen S, Mägi R, Milani L, Metspalu A, Starr JM, Milaneschi Y, Waken RJ, Gao C, Waldenberger M, Peters A, Strauch K, Meitinger T, Roenneberg T, Völker U, Dörr M, Shu XO, Mukherjee S, Hillman DR, Kähönen M, Wagenknecht LE, Gieger C, Grabe HJ, Zheng W, Palmer LJ, Lehtimäki T, Gudnason V, Morrison AC, Pereira AC, Fornage M, Psaty BM, van Duijn CM, Liu CT, Kelly TN, Evans MK, Bouchard C, Fox ER, Kooperberg C, Zhu X, Lakka TA, Esko T, North KE, Deary IJ, Snieder H, Penninx BWJH, Gauderman WJ, Rao DC, Redline S, van Heemst D.
PMID: 33859359
Mol Psychiatry. 2021 Nov;26(11):6293-6304. doi: 10.1038/s41380-021-01087-0. Epub 2021 Apr 15.

Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we performed genome-wide...

Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization: A Mendelian Randomization Study in the UK Biobank.

Circulation. Genomic and precision medicine

Young WJ, Warren HR, Mook-Kanamori DO, Ramírez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D, Lambiase PD, Jukema JW, Munroe PB, Noordam R.
PMID: 33887147
Circ Genom Precis Med. 2021 Jun;14(3):e003231. doi: 10.1161/CIRCGEN.120.003231. Epub 2021 Apr 22.

BACKGROUND: ECG markers of ventricular depolarization and repolarization are associated with an increased risk of arrhythmia and sudden cardiac death. Our prior work indicated lower serum calcium concentrations are associated with longer QT and JT intervals in the general...

Natriuretic Peptides in Post-mortem Brain Tissue and Cerebrospinal Fluid of Non-demented Humans and Alzheimer's Disease Patients.

Frontiers in neuroscience

Mahinrad S, Bulk M, van der Velpen I, Mahfouz A, van Roon-Mom W, Fedarko N, Yasar S, Sabayan B, van Heemst D, van der Weerd L.
PMID: 30534047
Front Neurosci. 2018 Nov 26;12:864. doi: 10.3389/fnins.2018.00864. eCollection 2018.

Animal studies suggest the involvement of natriuretic peptides (NP) in several brain functions that are known to be disturbed during Alzheimer's disease (AD). However, it remains unclear whether such findings extend to humans. In this study, we aimed to:...

Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism.

JAMA

Mooijaart SP, Du Puy RS, Stott DJ, Kearney PM, Rodondi N, Westendorp RGJ, den Elzen WPJ, Postmus I, Poortvliet RKE, van Heemst D, van Munster BC, Peeters RP, Ford I, Kean S, Messow CM, Blum MR, Collet TH, Watt T, Dekkers OM, Jukema JW, Smit JWA, Langhorne P, Gussekloo J.
PMID: 31664429
JAMA. 2019 Nov 26;322(20):1977-1986. doi: 10.1001/jama.2019.17274.

IMPORTANCE: It is unclear whether levothyroxine treatment provides clinically important benefits in adults aged 80 years and older with subclinical hypothyroidism.OBJECTIVE: To determine the association of levothyroxine treatment for subclinical hypothyroidism with thyroid-related quality of life in adults aged...

Classical risk factors for primary coronary artery disease from an aging perspective through Mendelian Randomization.

GeroScience

Jansen SA, Huiskens B, Trompet S, Jukema J, Mooijaart SP, Willems van Dijk K, van Heemst D, Noordam R.
PMID: 34932184
Geroscience. 2021 Dec 21; doi: 10.1007/s11357-021-00498-9. Epub 2021 Dec 21.

The significance of classical risk factors in coronary artery disease (CAD) remains unclear in older age due to possible changes in underlying disease pathologies. Therefore, we conducted Mendelian Randomization approaches to investigate the causal relationship between classical risk factors...

Relationships Between 24-hour LH and Testosterone Concentrations and With Other Pituitary Hormones in Healthy Older Men.

Journal of the Endocrine Society

van der Spoel E, Roelfsema F, van Heemst D.
PMID: 34337275
J Endocr Soc. 2021 Apr 29;5(9):bvab075. doi: 10.1210/jendso/bvab075. eCollection 2021 Sep 01.

OBJECTIVE: To investigate the relationship between LH and testosterone (T), which characteristics associate with the strength of this relationship, and their interrelationships with GH, TSH, cortisol, and ACTH.DESIGN: Hormones were measured in serum samples collected every 10 minutes during...

Showing 1 to 12 of 65 entries