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van der Spoel E, Roelfsema F, van Heemst D. Relationships Between 24-hour LH and Testosterone Concentrations and With Other Pituitary Hormones in Healthy Older Men. J Endocr Soc. 2021;5(9):bvab075doi: 10.1210/jendso/bvab075.
van der Spoel, E., Roelfsema, F., & van Heemst, D. (2021). Relationships Between 24-hour LH and Testosterone Concentrations and With Other Pituitary Hormones in Healthy Older Men. Journal of the Endocrine Society, 5(9), bvab075. https://doi.org/10.1210/jendso/bvab075
van der Spoel, Evie, et al. "Relationships Between 24-hour LH and Testosterone Concentrations and With Other Pituitary Hormones in Healthy Older Men." Journal of the Endocrine Society vol. 5,9 (2021): bvab075. doi: https://doi.org/10.1210/jendso/bvab075
van der Spoel E, Roelfsema F, van Heemst D. Relationships Between 24-hour LH and Testosterone Concentrations and With Other Pituitary Hormones in Healthy Older Men. J Endocr Soc. 2021 Apr 29;5(9):bvab075. doi: 10.1210/jendso/bvab075. eCollection 2021 Sep 01. PMID: 34337275; PMCID: PMC8315483.
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J Endocr Soc. 2021 Apr 29;5(9):bvab075. doi: 10.1210/jendso/bvab075. eCollection 2021 Sep 01.

Relationships Between 24-hour LH and Testosterone Concentrations and With Other Pituitary Hormones in Healthy Older Men.

Journal of the Endocrine Society

Evie van der Spoel, Ferdinand Roelfsema, Diana van Heemst

Affiliations

  1. Section Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.
  2. Section Endocrinology, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.

PMID: 34337275 PMCID: PMC8315483 DOI: 10.1210/jendso/bvab075

Abstract

OBJECTIVE: To investigate the relationship between LH and testosterone (T), which characteristics associate with the strength of this relationship, and their interrelationships with GH, TSH, cortisol, and ACTH.

DESIGN: Hormones were measured in serum samples collected every 10 minutes during 24 hours from 20 healthy men, comprising 10 offspring of long-lived families and 10 control subjects, with a mean (SD) age of 65.6 (5.3) years. We performed cross-correlation analyses to assess the relative strength between 2 timeseries for all possible time shifts.

RESULTS: Mean (95% CI) maximal correlation was 0.21 (0.10-0.31) at lag time of 60 minutes between LH and total T concentrations. Results were comparable for calculated free, bioavailable, or secretion rates of T. Men with strong LH-T cross-correlations had, compared with men with no cross-correlation, lower fat mass (18.5 [14.9-19.7] vs. 22.3 [18.4-29.4] kg), waist circumference (93.6 [5.7] vs. 103.1 [12.0] cm), high-sensitivity C-reactive protein (0.7 [0.4-1.3] vs. 1.8 [0.8-12.3] mg/L), IL-6 (0.8 [0.6-1.0] vs. 1.2 [0.9-3.0] pg/mL), and 24-hour mean LH (4.3 [2.0] vs. 6.1 [1.5] U/L), and stronger LH-T feedforward synchrony (1.5 [0.3] vs. 1.9 [0.2]). Furthermore, T was positively cross-correlated with TSH (0.32 [0.21-0.43]), cortisol (0.26 [0.19-0.33]), and ACTH (0.26 [0.19-0.32]).

CONCLUSIONS: LH is followed by T with a delay of 60 minutes in healthy older men. Men with a strong LH-T relationship had more favorable body composition, inflammatory markers, LH levels, and LH-T feedforward synchrony. We observed positive correlations between T and TSH, cortisol, and ACTH.

© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.

Keywords: ageing; cross-correlation; luteinizing hormone; men; pituitary hormones; testosterone

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