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Wang H, Noordam R, Cade BE, et al. Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure. Mol Psychiatry. 2021;26(11):6293-6304doi: 10.1038/s41380-021-01087-0.
Wang, H., Noordam, R., Cade, B. E., Schwander, K., Winkler, T. W., Lee, J., Sung, Y. J., Bentley, A. R., Manning, A. K., Aschard, H., Kilpeläinen, T. O., Ilkov, M., Brown, M. R., Horimoto, A. R., Richard, M., Bartz, T. M., Vojinovic, D., Lim, E., Nierenberg, J. L., Liu, Y., Chitrala, K., Rankinen, T., Musani, S. K., Franceschini, N., Rauramaa, R., Alver, M., Zee, P. C., Harris, S. E., van der Most, P. J., Nolte, I. M., Munroe, P. B., Palmer, N. D., Kühnel, B., Weiss, S., Wen, W., Hall, K. A., Lyytikäinen, L. P., O'Connell, J., Eiriksdottir, G., Launer, L. J., de Vries, P. S., Arking, D. E., Chen, H., Boerwinkle, E., Krieger, J. E., Schreiner, P. J., Sidney, S., Shikany, J. M., Rice, K., Chen, Y. I., Gharib, S. A., Bis, J. C., Luik, A. I., Ikram, M. A., Uitterlinden, A. G., Amin, N., Xu, H., Levy, D., He, J., Lohman, K. K., Zonderman, A. B., Rice, T. K., Sims, M., Wilson, G., Sofer, T., Rich, S. S., Palmas, W., Yao, J., Guo, X., Rotter, J. I., Biermasz, N. R., Mook-Kanamori, D. O., Martin, L. W., Barac, A., Wallace, R. B., Gottlieb, D. J., Komulainen, P., Heikkinen, S., Mägi, R., Milani, L., Metspalu, A., Starr, J. M., Milaneschi, Y., Waken, R. J., Gao, C., Waldenberger, M., Peters, A., Strauch, K., Meitinger, T., Roenneberg, T., Völker, U., Dörr, M., Shu, X. O., Mukherjee, S., Hillman, D. R., Kähönen, M., Wagenknecht, L. E., Gieger, C., Grabe, H. J., Zheng, W., Palmer, L. J., Lehtimäki, T., Gudnason, V., Morrison, A. C., Pereira, A. C., Fornage, M., Psaty, B. M., van Duijn, C. M., Liu, C. T., Kelly, T. N., Evans, M. K., Bouchard, C., Fox, E. R., Kooperberg, C., Zhu, X., Lakka, T. A., Esko, T., North, K. E., Deary, I. J., Snieder, H., Penninx, B. W. J. H., Gauderman, W. J., Rao, D. C., Redline, S., & van Heemst, D. (2021). Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure. Molecular psychiatry, 26(11), 6293-6304. https://doi.org/10.1038/s41380-021-01087-0
Wang, Heming, et al. "Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure." Molecular psychiatry vol. 26,11 (2021): 6293-6304. doi: https://doi.org/10.1038/s41380-021-01087-0
Wang H, Noordam R, Cade BE, Schwander K, Winkler TW, Lee J, Sung YJ, Bentley AR, Manning AK, Aschard H, Kilpeläinen TO, Ilkov M, Brown MR, Horimoto AR, Richard M, Bartz TM, Vojinovic D, Lim E, Nierenberg JL, Liu Y, Chitrala K, Rankinen T, Musani SK, Franceschini N, Rauramaa R, Alver M, Zee PC, Harris SE, van der Most PJ, Nolte IM, Munroe PB, Palmer ND, Kühnel B, Weiss S, Wen W, Hall KA, Lyytikäinen LP, O'Connell J, Eiriksdottir G, Launer LJ, de Vries PS, Arking DE, Chen H, Boerwinkle E, Krieger JE, Schreiner PJ, Sidney S, Shikany JM, Rice K, Chen YI, Gharib SA, Bis JC, Luik AI, Ikram MA, Uitterlinden AG, Amin N, Xu H, Levy D, He J, Lohman KK, Zonderman AB, Rice TK, Sims M, Wilson G, Sofer T, Rich SS, Palmas W, Yao J, Guo X, Rotter JI, Biermasz NR, Mook-Kanamori DO, Martin LW, Barac A, Wallace RB, Gottlieb DJ, Komulainen P, Heikkinen S, Mägi R, Milani L, Metspalu A, Starr JM, Milaneschi Y, Waken RJ, Gao C, Waldenberger M, Peters A, Strauch K, Meitinger T, Roenneberg T, Völker U, Dörr M, Shu XO, Mukherjee S, Hillman DR, Kähönen M, Wagenknecht LE, Gieger C, Grabe HJ, Zheng W, Palmer LJ, Lehtimäki T, Gudnason V, Morrison AC, Pereira AC, Fornage M, Psaty BM, van Duijn CM, Liu CT, Kelly TN, Evans MK, Bouchard C, Fox ER, Kooperberg C, Zhu X, Lakka TA, Esko T, North KE, Deary IJ, Snieder H, Penninx BWJH, Gauderman WJ, Rao DC, Redline S, van Heemst D. Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure. Mol Psychiatry. 2021 Nov;26(11):6293-6304. doi: 10.1038/s41380-021-01087-0. Epub 2021 Apr 15. PMID: 33859359; PMCID: PMC8517040.
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Mol Psychiatry. 2021 Nov;26(11):6293-6304. doi: 10.1038/s41380-021-01087-0. Epub 2021 Apr 15.

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.

Molecular psychiatry

Heming Wang, Raymond Noordam, Brian E Cade, Karen Schwander, Thomas W Winkler, Jiwon Lee, Yun Ju Sung, Amy R Bentley, Alisa K Manning, Hugues Aschard, Tuomas O Kilpeläinen, Marjan Ilkov, Michael R Brown, Andrea R Horimoto, Melissa Richard, Traci M Bartz, Dina Vojinovic, Elise Lim, Jovia L Nierenberg, Yongmei Liu, Kumaraswamynaidu Chitrala, Tuomo Rankinen, Solomon K Musani, Nora Franceschini, Rainer Rauramaa, Maris Alver, Phyllis C Zee, Sarah E Harris, Peter J van der Most, Ilja M Nolte, Patricia B Munroe, Nicholette D Palmer, Brigitte Kühnel, Stefan Weiss, Wanqing Wen, Kelly A Hall, Leo-Pekka Lyytikäinen, Jeff O'Connell, Gudny Eiriksdottir, Lenore J Launer, Paul S de Vries, Dan E Arking, Han Chen, Eric Boerwinkle, Jose E Krieger, Pamela J Schreiner, Stephen Sidney, James M Shikany, Kenneth Rice, Yii-Der Ida Chen, Sina A Gharib, Joshua C Bis, Annemarie I Luik, M Arfan Ikram, André G Uitterlinden, Najaf Amin, Hanfei Xu, Daniel Levy, Jiang He, Kurt K Lohman, Alan B Zonderman, Treva K Rice, Mario Sims, Gregory Wilson, Tamar Sofer, Stephen S Rich, Walter Palmas, Jie Yao, Xiuqing Guo, Jerome I Rotter, Nienke R Biermasz, Dennis O Mook-Kanamori, Lisa W Martin, Ana Barac, Robert B Wallace, Daniel J Gottlieb, Pirjo Komulainen, Sami Heikkinen, Reedik Mägi, Lili Milani, Andres Metspalu, John M Starr, Yuri Milaneschi, R J Waken, Chuan Gao, Melanie Waldenberger, Annette Peters, Konstantin Strauch, Thomas Meitinger, Till Roenneberg, Uwe Völker, Marcus Dörr, Xiao-Ou Shu, Sutapa Mukherjee, David R Hillman, Mika Kähönen, Lynne E Wagenknecht, Christian Gieger, Hans J Grabe, Wei Zheng, Lyle J Palmer, Terho Lehtimäki, Vilmundur Gudnason, Alanna C Morrison, Alexandre C Pereira, Myriam Fornage, Bruce M Psaty, Cornelia M van Duijn, Ching-Ti Liu, Tanika N Kelly, Michele K Evans, Claude Bouchard, Ervin R Fox, Charles Kooperberg, Xiaofeng Zhu, Timo A Lakka, Tõnu Esko, Kari E North, Ian J Deary, Harold Snieder, Brenda W J H Penninx, W James Gauderman, Dabeeru C Rao, Susan Redline, Diana van Heemst

Affiliations

  1. Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. [email protected].
  2. Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA. [email protected].
  3. Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
  4. Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  5. Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  6. Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
  7. Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
  8. Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
  9. Joint Carnegie Mellon University-University of Pittsburgh PhD Program in Computational Biology, Pittsburgh, PA, USA.
  10. Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  11. Pittsburgh Center for Evolutionary Biology and Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  12. Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  13. Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  14. Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
  15. Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur, Paris, France.
  16. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  17. Department of Environmental Medicine and Public Health, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  18. Icelandic Heart Association, Kopavogur, Iceland.
  19. Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  20. Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
  21. Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
  22. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  23. Department of Biostatistics, University of Washington, Seattle, WA, USA.
  24. Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  25. Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.
  26. Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  27. Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
  28. Division of Cardiology, Department of Medicine, Duke Molecular Physiology Institute Duke University School of Medicine, Durham, NC, USA.
  29. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
  30. Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
  31. Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
  32. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
  33. Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
  34. Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
  35. Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland.
  36. Division of Sleep Medicine, Department of Neurology, Northwestern University, Chicago, IL, USA.
  37. Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK.
  38. Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  39. Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  40. National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, London, UK.
  41. Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  42. Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  43. Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  44. Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
  45. German Center for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.
  46. Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
  47. School of Public Health, The University of Adelaide, Adelaide, SA, Australia.
  48. Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
  49. Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
  50. Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
  51. Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
  52. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  53. Center for Precision Health, School of Public Health & School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  54. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
  55. Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
  56. Kaiser Permanente Northern California, Oakland, CA, USA.
  57. Division of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
  58. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
  59. Computational Medicine Core, Center for Lung Biology, UW Medicine Sleep Center, Department of Medicine, University of Washington, Seattle, WA, USA.
  60. Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
  61. Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
  62. Population Sciences Branch, National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, MA, USA.
  63. JHS Graduate Training and Education Center, Jackson State University, Jackson, MS, USA.
  64. Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
  65. Division of General Medicine, Department of Medicine, Columbia University, New York, NY, USA.
  66. Division of Endocrinology, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.
  67. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.
  68. Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
  69. George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
  70. MedStar Heart and Vascular Institute, Washington, DC, USA.
  71. Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA.
  72. VA Boston Healthcare System, Boston, MA, USA.
  73. Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Finland.
  74. Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
  75. Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, UK.
  76. Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit, Amsterdam, HJ, The Netherlands.
  77. Division of Cardiology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
  78. Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  79. German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Neuherberg, Germany.
  80. Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.
  81. Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  82. Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany.
  83. Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  84. Institute and Polyclinic for Occupational-, Social- and Environmental Medicine, LMU Munich, Munich, Germany.
  85. Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
  86. Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network, Adelaide, SA, Australia.
  87. Adelaide Institute for Sleep Health, Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.
  88. Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia.
  89. Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
  90. Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
  91. Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  92. German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
  93. Department Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
  94. Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
  95. Department of Genetics, Harvard Medical School, Boston, MA, USA.
  96. Cardiovascular Health Research Unit, Departments of Epidemiology and Health Services, University of Washington, Seattle, WA, USA.
  97. Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  98. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  99. Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
  100. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
  101. Division of Biostatistics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
  102. Division of Pulmonary Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  103. Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands. [email protected].

PMID: 33859359 PMCID: PMC8517040 DOI: 10.1038/s41380-021-01087-0

Abstract

Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we performed genome-wide gene by short or long sleep duration interaction analyses on four BP traits (systolic BP, diastolic BP, mean arterial pressure, and pulse pressure) across five ancestry groups in two stages using 2 degree of freedom (df) joint test followed by 1df test of interaction effects. Primary multi-ancestry analysis in 62,969 individuals in stage 1 identified three novel gene by sleep interactions that were replicated in an additional 59,296 individuals in stage 2 (stage 1 + 2 P

© 2021. The Author(s), under exclusive licence to Springer Nature Limited.

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