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Zhang Y, Li Y, Li W, et al. Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells at Various Passages on Acute Liver Failure in Rats. Stem Cells Int. 2018;2018:7159465doi: 10.1155/2018/7159465.
Zhang, Y., Li, Y., Li, W., Cai, J., Yue, M., Jiang, L., Xu, R., Zhang, L., Li, J., & Zhu, C. (2018). Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells at Various Passages on Acute Liver Failure in Rats. Stem cells international, 20187159465. https://doi.org/10.1155/2018/7159465
Zhang, Yongting, et al. "Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells at Various Passages on Acute Liver Failure in Rats." Stem cells international vol. 2018 (2018): 7159465. doi: https://doi.org/10.1155/2018/7159465
Zhang Y, Li Y, Li W, Cai J, Yue M, Jiang L, Xu R, Zhang L, Li J, Zhu C. Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells at Various Passages on Acute Liver Failure in Rats. Stem Cells Int. 2018 Nov 14;2018:7159465. doi: 10.1155/2018/7159465. eCollection 2018. PMID: 30538751; PMCID: PMC6261392.
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Stem Cells Int. 2018 Nov 14;2018:7159465. doi: 10.1155/2018/7159465. eCollection 2018.

Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells at Various Passages on Acute Liver Failure in Rats.

Stem cells international

Yongting Zhang, Yuwen Li, Wenting Li, Jie Cai, Ming Yue, Longfeng Jiang, Ruirui Xu, Lili Zhang, Jun Li, Chuanlong Zhu

Affiliations

  1. Department of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
  2. Department of Pediatrics, The Affiliated Hospital of Yangzhou University, Yangzhou 225000, China.
  3. Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
  4. Third Liver Unit, Department of Infectious Disease, The First Affiliated Hospital of Science and Technology of China, Hefei 230001, China.

PMID: 30538751 PMCID: PMC6261392 DOI: 10.1155/2018/7159465

Abstract

Recent studies have described beneficial effects of an infusion of mesenchymal stem cells (MSCs) derived from Wharton's jelly tissue, for the treatment of acute liver failure (ALF). However, data on the therapeutic potential of culture-expanded MSCs are lacking. We examined the therapeutic potential of passage five (P5) and ten (P10) human umbilical cord- (hUC-) MSCs via their transplantation into Sprague-Dawley (SD) rats with D-galactosamine (D-GalN) and LPS-induced acute liver failure (ALF). SD rats were randomly divided into three groups: control group, P5 hUC-MSCs group, and P10 hUC-MSCs group. After transplantation, P5 hUC-MSCs provided a significant survival benefit. The analysis of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin (TBIL) levels showed that transplantation with P5 hUC-MSCs was more effective than treatment with P10 hUC-MSCs. P5 hUC-MSCs also successfully downregulated the hepatic activity index (HAI) scores. Compared to P10 hUC-MSCs

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