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Estébanez B, de Paz JA, Cuevas MJ, et al. Endoplasmic Reticulum Unfolded Protein Response, Aging and Exercise: An Update. Front Physiol. 2018;9:1744doi: 10.3389/fphys.2018.01744.
Estébanez, B., de Paz, J. A., Cuevas, M. J., & González-Gallego, J. (2018). Endoplasmic Reticulum Unfolded Protein Response, Aging and Exercise: An Update. Frontiers in physiology, 91744. https://doi.org/10.3389/fphys.2018.01744
Estébanez, Brisamar, et al. "Endoplasmic Reticulum Unfolded Protein Response, Aging and Exercise: An Update." Frontiers in physiology vol. 9 (2018): 1744. doi: https://doi.org/10.3389/fphys.2018.01744
Estébanez B, de Paz JA, Cuevas MJ, González-Gallego J. Endoplasmic Reticulum Unfolded Protein Response, Aging and Exercise: An Update. Front Physiol. 2018 Dec 05;9:1744. doi: 10.3389/fphys.2018.01744. eCollection 2018. PMID: 30568599; PMCID: PMC6290262.
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Front Physiol. 2018 Dec 05;9:1744. doi: 10.3389/fphys.2018.01744. eCollection 2018.

Endoplasmic Reticulum Unfolded Protein Response, Aging and Exercise: An Update.

Frontiers in physiology

Brisamar Estébanez, José A de Paz, María J Cuevas, Javier González-Gallego

Affiliations

  1. Institute of Biomedicine (IBIOMED), University of León, León, Spain.
  2. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.

PMID: 30568599 PMCID: PMC6290262 DOI: 10.3389/fphys.2018.01744

Abstract

The endoplasmic reticulum (ER) is a dynamic and multifunctional organelle responsible for protein biosynthesis, folding, assembly and modifications. Loss of protein folding regulation, which leads to unfolded or misfolded proteins accumulation inside the ER lumen, drives ER stress (ERS) and unfolded protein response (UPR) activation. During aging, there is a decline in the ability of the cell to handle protein folding, accumulation and aggregation, and the function of UPR is compromised. There is a progressive failure of the chaperoning systems and a decline in many of its components, so that the UPR activation cannot rescue the ERS. Physical activity has been proposed as a powerful tool against aged-related diseases, which are linked to ERS. Interventional studies have demonstrated that regular exercise is able to decrease oxidative stress and inflammation and reverse mitochondrial and ER dysfunctions. Exercise-induced metabolic stress could activate the UPR since muscle contraction is directly involved in its activation, mediating exercise-induced adaptation responses. In fact, regular moderate-intensity exercise-induced ERS acts as a protective mechanism against current and future stressors. However, biological responses vary according to exercise intensity and therefore induce different degrees of ERS and UPR activation. This article reviews the effects of aging and exercise on ERS and UPR, also analyzing possible changes induced by different types of exercise in elderly subjects.

Keywords: aging; elderly; endoplasmic reticulum stress; exercise; training; unfolded protein response

References

  1. Int J Sport Nutr Exerc Metab. 2001 Dec;11 Suppl:S9-15 - PubMed
  2. J Biol Chem. 2003 May 9;278(19):16726-31 - PubMed
  3. Biochem Biophys Res Commun. 2003 Jun 6;305(3):566-72 - PubMed
  4. Exp Gerontol. 2004 May;39(5):735-44 - PubMed
  5. Neurobiol Aging. 2006 Jul;27(7):973-82 - PubMed
  6. J Gerontol A Biol Sci Med Sci. 2006 May;61(5):435-43 - PubMed
  7. Biochem Biophys Res Commun. 2007 Apr 6;355(2):365-70 - PubMed
  8. J Appl Physiol (1985). 2008 May;104(5):1452-61 - PubMed
  9. J Neurosci. 2008 Jun 25;28(26):6539-48 - PubMed
  10. Int J Mol Med. 2008 Oct;22(4):529-39 - PubMed
  11. Ageing Res Rev. 2009 Jul;8(3):150-9 - PubMed
  12. Rev Neurosci. 2009;20(1):23-37 - PubMed
  13. Brain Res. 2010 Mar 4;1317:13-23 - PubMed
  14. Am J Pathol. 2010 May;176(5):2163-76 - PubMed
  15. Cell Biochem Funct. 2010 Apr;28(3):202-10 - PubMed
  16. Eur J Appl Physiol. 2011 Sep;111(9):2015-23 - PubMed
  17. Cell Metab. 2011 Feb 2;13(2):160-9 - PubMed
  18. Aging Cell. 2011 Aug;10(4):640-9 - PubMed
  19. J Appl Physiol (1985). 2011 Jul;111(1):135-42 - PubMed
  20. Cell Calcium. 2012 Jan;51(1):31-9 - PubMed
  21. Am J Respir Cell Mol Biol. 2012 Jun;46(6):748-56 - PubMed
  22. J Physiol Biochem. 2013 Jun;69(2):215-25 - PubMed
  23. PLoS One. 2012;7(11):e50407 - PubMed
  24. Am J Physiol Cell Physiol. 2013 Mar 1;304(5):C422-30 - PubMed
  25. Am J Pathol. 2013 Sep;183(3):774-85 - PubMed
  26. Apoptosis. 2013 Nov;18(11):1332-1347 - PubMed
  27. Aging Cell. 2014 Feb;13(1):131-41 - PubMed
  28. Aging (Albany NY). 2013 Dec;5(12):884-901 - PubMed
  29. Neurobiol Aging. 2014 Jun;35(6):1431-41 - PubMed
  30. Korean J Physiol Pharmacol. 2014 Jun;18(3):211-6 - PubMed
  31. Am J Physiol Regul Integr Comp Physiol. 2014 Sep 15;307(6):R664-9 - PubMed
  32. J Gerontol A Biol Sci Med Sci. 2015 Nov;70(11):1320-9 - PubMed
  33. Age (Dordr). 2014;36(6):9734 - PubMed
  34. Mol Neurobiol. 2016 Jan;53(1):532-544 - PubMed
  35. Trends Cardiovasc Med. 2015 Apr;25(3):243-7 - PubMed
  36. Calcif Tissue Int. 2015 Feb;96(2):123-8 - PubMed
  37. Trends Biochem Sci. 2015 Mar;40(3):141-8 - PubMed
  38. Cancer Lett. 2015 May 1;360(2):257-68 - PubMed
  39. Metabolism. 2015 Jul;64(7):780-92 - PubMed
  40. J Pineal Res. 2015 Oct;59(3):292-307 - PubMed
  41. Mech Ageing Dev. 2015 Sep;150:12-9 - PubMed
  42. J Exerc Nutrition Biochem. 2015 Sep;19(3):191-7 - PubMed
  43. Biochem Biophys Res Commun. 2015 Dec 25;468(4):702-7 - PubMed
  44. Life Sci. 2016 Jan 15;145:144-51 - PubMed
  45. J Exp Biol. 2016 Jan;219(Pt 2):214-25 - PubMed
  46. Aging (Albany NY). 2016 Jan;8(1):127-46 - PubMed
  47. Age (Dordr). 2016 Apr;38(2):33 - PubMed
  48. J Gerontol A Biol Sci Med Sci. 2017 Mar 1;72(3):299-308 - PubMed
  49. Biofactors. 2016 Jul 8;42(4):368-75 - PubMed
  50. Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C1024-36 - PubMed
  51. Brain Behav Immun. 2016 Oct;57:347-359 - PubMed
  52. J Cell Mol Med. 2016 Nov;20(11):2208-2212 - PubMed
  53. Metabolism. 2016 Sep;65(9):1409-20 - PubMed
  54. Free Radic Biol Med. 2016 Oct;99:308-322 - PubMed
  55. Antioxid Redox Signal. 2017 Aug 1;27(4):185-200 - PubMed
  56. Aging (Albany NY). 2017 Feb 2;9(2):408-418 - PubMed
  57. Appl Physiol Nutr Metab. 2017 Apr;42(4):354-360 - PubMed
  58. Int J Vasc Med. 2017;2017:2049217 - PubMed

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