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Wu X, Zhang M. Effects of androgen and progestin on the proliferation and differentiation of osteoblasts. Exp Ther Med. 2018;16(6):4722-4728doi: 10.3892/etm.2018.6772.
Wu, X., & Zhang, M. (2018). Effects of androgen and progestin on the proliferation and differentiation of osteoblasts. Experimental and therapeutic medicine, 16(6), 4722-4728. https://doi.org/10.3892/etm.2018.6772
Wu, Xinchen, and Zhang, Mengqi. "Effects of androgen and progestin on the proliferation and differentiation of osteoblasts." Experimental and therapeutic medicine vol. 16,6 (2018): 4722-4728. doi: https://doi.org/10.3892/etm.2018.6772
Wu X, Zhang M. Effects of androgen and progestin on the proliferation and differentiation of osteoblasts. Exp Ther Med. 2018 Dec;16(6):4722-4728. doi: 10.3892/etm.2018.6772. Epub 2018 Sep 19. PMID: 30542427; PMCID: PMC6257455.
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Exp Ther Med. 2018 Dec;16(6):4722-4728. doi: 10.3892/etm.2018.6772. Epub 2018 Sep 19.

Effects of androgen and progestin on the proliferation and differentiation of osteoblasts.

Experimental and therapeutic medicine

Xinchen Wu, Mengqi Zhang

Affiliations

  1. Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NY 07030, USA.
  2. Department of Pediatrics, Peking Union Medical College Hospital, Beijing 100730, P.R. China.

PMID: 30542427 PMCID: PMC6257455 DOI: 10.3892/etm.2018.6772

Abstract

Osteoporosis is liable to affect patients with gonadal hormone deficiency, and a supplement of androgens may be used to increase bone density of patients with osteoporosis. Since the androgens currently used may cause severe side effects, it is useful to investigate the effect of other androgens and progestin on bone improvement. The aim of the current study was to investigate the effects of pregnenolone (Preg), androstenedione (AD), etiocholanolone (Etio), androsterone (An), nandrolone (NA) and testosterone (T) on the proliferation and differentiation of osteoblasts for potential clinical applications. Human osteoblasts were cultured and treated with androgens and progestin, including Preg, AD, Etio, An, NA, and T, at concentrations of 0, 10

Keywords: androgen; androstenedione; androsterone; etiocholanolone; nandrolone; osteoblasts; pregnenolone; testosterone

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