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Pijl MKJ, Bussu G, Charman T, et al. Temperament as an Early Risk Marker for Autism Spectrum Disorders? A Longitudinal Study of High-Risk and Low-Risk Infants. J Autism Dev Disord. 2019;49(5):1825-1836doi: 10.1007/s10803-018-3855-8.
Pijl, M. K. J., Bussu, G., Charman, T., Johnson, M. H., Jones, E. J. H., Pasco, G., Oosterling, I. J., Rommelse, N. N. J., Buitelaar, J. K. (2019). Temperament as an Early Risk Marker for Autism Spectrum Disorders? A Longitudinal Study of High-Risk and Low-Risk Infants. Journal of autism and developmental disorders, 49(5), 1825-1836. https://doi.org/10.1007/s10803-018-3855-8
Pijl, M K J, et al. "Temperament as an Early Risk Marker for Autism Spectrum Disorders? A Longitudinal Study of High-Risk and Low-Risk Infants." Journal of autism and developmental disorders vol. 49,5 (2019): 1825-1836. doi: https://doi.org/10.1007/s10803-018-3855-8
Pijl MKJ, Bussu G, Charman T, Johnson MH, Jones EJH, Pasco G, Oosterling IJ, Rommelse NNJ, Buitelaar JK. Temperament as an Early Risk Marker for Autism Spectrum Disorders? A Longitudinal Study of High-Risk and Low-Risk Infants. J Autism Dev Disord. 2019 May;49(5):1825-1836. doi: 10.1007/s10803-018-3855-8. PMID: 30607781.
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J Autism Dev Disord. 2019 May;49(5):1825-1836. doi: 10.1007/s10803-018-3855-8.

Temperament as an Early Risk Marker for Autism Spectrum Disorders? A Longitudinal Study of High-Risk and Low-Risk Infants.

Journal of autism and developmental disorders

M K J Pijl, G Bussu, T Charman, M H Johnson, E J H Jones, G Pasco, I J Oosterling, N N J Rommelse, J K Buitelaar,

Affiliations

  1. Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands. [email protected].
  2. Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, The Netherlands. [email protected].
  3. Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.
  4. Psychology Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  5. Centre for Brain and Cognitive Development, Birkbeck College, University of London, London, UK.
  6. Psychology Department, University of Cambridge, Cambridge, UK.
  7. Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, The Netherlands.
  8. Department of Psychiatry, Radboud University Medical Centre, Nijmegen, The Netherlands.

PMID: 30607781 DOI: 10.1007/s10803-018-3855-8

Abstract

To investigate temperament as an early risk marker for autism spectrum disorder (ASD), we examined parent-reported temperament for high-risk (HR, n = 170) and low-risk (LR, n = 77) siblings at 8, 14, and 24 months. Diagnostic assessment was performed at 36 months. Group-based analyses showed linear risk gradients, with more atypical temperament for HR-ASD, followed by HR-Atypical, HR-Typical, and LR siblings. Temperament differed significantly between outcome groups (0.03 ≤ η

Keywords: Autism spectrum disorder; High-risk; Longitudinal; Machine learning; Temperament

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