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Smith ER, Capo-Chichi CD, Xu XX. Defective Nuclear Lamina in Aneuploidy and Carcinogenesis. Front Oncol. 2018;8:529doi: 10.3389/fonc.2018.00529.
Smith, E. R., Capo-Chichi, C. D., & Xu, X. X. (2018). Defective Nuclear Lamina in Aneuploidy and Carcinogenesis. Frontiers in oncology, 8529. https://doi.org/10.3389/fonc.2018.00529
Smith, Elizabeth R, et al. "Defective Nuclear Lamina in Aneuploidy and Carcinogenesis." Frontiers in oncology vol. 8 (2018): 529. doi: https://doi.org/10.3389/fonc.2018.00529
Smith ER, Capo-Chichi CD, Xu XX. Defective Nuclear Lamina in Aneuploidy and Carcinogenesis. Front Oncol. 2018 Nov 20;8:529. doi: 10.3389/fonc.2018.00529. eCollection 2018. PMID: 30524960; PMCID: PMC6256246.
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Front Oncol. 2018 Nov 20;8:529. doi: 10.3389/fonc.2018.00529. eCollection 2018.

Defective Nuclear Lamina in Aneuploidy and Carcinogenesis.

Frontiers in oncology

Elizabeth R Smith, Callinice D Capo-Chichi, Xiang-Xi Xu

Affiliations

  1. Department of Cell Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United States.
  2. Laboratory of Biochemistry and Molecular Biology, Institute of Biomedical Sciences, University of Abomey-Calavi, Abomey Calavi, Benin.

PMID: 30524960 PMCID: PMC6256246 DOI: 10.3389/fonc.2018.00529

Abstract

Aneuploidy, loss or gain of whole chromosomes, is a prominent feature of carcinomas, and is generally considered to play an important role in the initiation and progression of cancer. In high-grade serous ovarian cancer, the only common gene aberration is the p53 point mutation, though extensive genomic perturbation is common due to severe aneuploidy, which presents as a deviant karyotype. Several mechanisms for the development of aneuploidy in cancer cells have been recognized, including chromosomal non-disjunction during mitosis, centrosome amplification, and more recently, nuclear envelope rupture at interphase. Many cancer types including ovarian cancer have lost or reduced expression of Lamin A/C, a structural component of the lamina matrix that underlies the nuclear envelope in differentiated cells. Several recent studies suggest that a nuclear lamina defect caused by the loss or reduction of Lamin A/C leads to failure in cytokinesis and formation of tetraploid cells, transient nuclear envelope rupture, and formation of nuclear protrusions and micronuclei during the cell cycle gap phase. Thus, loss and reduction of Lamin A/C underlies the two common features of cancer-aberrations in nuclear morphology and aneuploidy. We discuss here and emphasize the newly recognized mechanism of chromosomal instability due to the rupture of a defective nuclear lamina, which may account for the rapid genomic changes in carcinogenesis.

Keywords: aneuploidy; lamin A/C; nuclear budding; nuclear deformation; nuclear envelope; nuclear lamina; nuclear morphology; ovarian cancer

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