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Cakir B, Reich M, Lang S, et al. OCT Angiography of the Choriocapillaris in Central Serous Chorioretinopathy: A Quantitative Subgroup Analysis. Ophthalmol Ther. 2019;8(1):75-86doi: 10.1007/s40123-018-0159-1.
Cakir, B., Reich, M., Lang, S., Bühler, A., Ehlken, C., Grundel, B., Stech, M., Reichl, S., Stahl, A., Böhringer, D., Agostini, H., & Lange, C. (2019). OCT Angiography of the Choriocapillaris in Central Serous Chorioretinopathy: A Quantitative Subgroup Analysis. Ophthalmology and therapy, 8(1), 75-86. https://doi.org/10.1007/s40123-018-0159-1
Cakir, Bertan, et al. "OCT Angiography of the Choriocapillaris in Central Serous Chorioretinopathy: A Quantitative Subgroup Analysis." Ophthalmology and therapy vol. 8,1 (2019): 75-86. doi: https://doi.org/10.1007/s40123-018-0159-1
Cakir B, Reich M, Lang S, Bühler A, Ehlken C, Grundel B, Stech M, Reichl S, Stahl A, Böhringer D, Agostini H, Lange C. OCT Angiography of the Choriocapillaris in Central Serous Chorioretinopathy: A Quantitative Subgroup Analysis. Ophthalmol Ther. 2019 Mar;8(1):75-86. doi: 10.1007/s40123-018-0159-1. Epub 2019 Jan 07. PMID: 30617944; PMCID: PMC6393260.
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Ophthalmol Ther. 2019 Mar;8(1):75-86. doi: 10.1007/s40123-018-0159-1. Epub 2019 Jan 07.

OCT Angiography of the Choriocapillaris in Central Serous Chorioretinopathy: A Quantitative Subgroup Analysis.

Ophthalmology and therapy

Bertan Cakir, Michael Reich, Stefan Lang, Anima Bühler, Christoph Ehlken, Bastian Grundel, Milena Stech, Sabine Reichl, Andreas Stahl, Daniel Böhringer, Hansjürgen Agostini, Clemens Lange

Affiliations

  1. Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  2. Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany. [email protected].

PMID: 30617944 PMCID: PMC6393260 DOI: 10.1007/s40123-018-0159-1

Abstract

INTRODUCTION: To quantify optical coherence tomography angiography (OCTA) signal changes at the level of the choriocapillaris (CC) in patients with different stages of central serous chorioretinopathy (CSC) and to explore any correlation between subretinal fluid (SRF) and retinal pigment epithelium (RPE) alterations and the OCTA CC signal.

METHODS: One hundred one CSC eyes and 42 healthy control eyes were included in this retrospective study. CSC patients were allocated into four groups: acute, non-resolving, chronic atrophic and inactive CSC. CC OCTA images (AngioPlex

RESULTS: Active CSC subgroups demonstrated significantly more increased and decreased flow pixels in the CC compared with controls (p < 0.0001). No significant OCTA changes were seen within the active CSC groups or between the inactive and healthy subgroup. Spatial correlation analysis revealed a decreased OCTA signal in the SRF area and an increased signal outside the SRF area in acute CSC. Areas of RPE atrophy co-localized with areas of increased choriocapillaris OCTA signal, while areas with RPE alterations exhibited a normal signal compared with unaffected RPE.

CONCLUSION: The decreased OCTA signal in the area of SRF in acute CSC could be evidence of localized CC hypoperfusion or due to shadowing artifacts. The missing CC OCTA changes in altered RPE adjacent to atrophy argues against CC injury. Studies with higher resolution and optimized image acquisition are warranted to further validate our findings.

Keywords: Central serous chorioretinopathy; Choriocapillaris; OCT angiography

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