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Safarova MS, Satterfield BA, Fan X, et al. A phenome-wide association study to discover pleiotropic effects of . NPJ Genom Med. 2019;4:3doi: 10.1038/s41525-019-0078-7.
Safarova, M. S., Satterfield, B. A., Fan, X., Austin, E. E., Ye, Z., Bastarache, L., Zheng, N., Ritchie, M. D., Borthwick, K. M., Williams, M. S., Larson, E. B., Scrol, A., Jarvik, G. P., Crosslin, D. R., Leppig, K., Rasmussen-Torvik, L. J., Pendergrass, S. A., Sturm, A. C., Namjou, B., Shah, A. S., Carroll, R. J., Chung, W. K., Wei, W. Q., Feng, Q., Stein, C. M., Roden, D. M., Manolio, T. A., Schaid, D. J., Denny, J. C., Hebbring, S. J., de Andrade, M., & Kullo, I. J. (2019). A phenome-wide association study to discover pleiotropic effects of . NPJ genomic medicine, 43. https://doi.org/10.1038/s41525-019-0078-7
Safarova, Maya S, et al. "A phenome-wide association study to discover pleiotropic effects of ." NPJ genomic medicine vol. 4 (2019): 3. doi: https://doi.org/10.1038/s41525-019-0078-7
Safarova MS, Satterfield BA, Fan X, Austin EE, Ye Z, Bastarache L, Zheng N, Ritchie MD, Borthwick KM, Williams MS, Larson EB, Scrol A, Jarvik GP, Crosslin DR, Leppig K, Rasmussen-Torvik LJ, Pendergrass SA, Sturm AC, Namjou B, Shah AS, Carroll RJ, Chung WK, Wei WQ, Feng Q, Stein CM, Roden DM, Manolio TA, Schaid DJ, Denny JC, Hebbring SJ, de Andrade M, Kullo IJ. A phenome-wide association study to discover pleiotropic effects of . NPJ Genom Med. 2019 Feb 11;4:3. doi: 10.1038/s41525-019-0078-7. eCollection 2019. PMID: 30774981; PMCID: PMC6370860.
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NPJ Genom Med. 2019 Feb 11;4:3. doi: 10.1038/s41525-019-0078-7. eCollection 2019.

A phenome-wide association study to discover pleiotropic effects of .

NPJ genomic medicine

Maya S Safarova, Benjamin A Satterfield, Xiao Fan, Erin E Austin, Zhan Ye, Lisa Bastarache, Neil Zheng, Marylyn D Ritchie, Kenneth M Borthwick, Marc S Williams, Eric B Larson, Aaron Scrol, Gail P Jarvik, David R Crosslin, Kathleen Leppig, Laura J Rasmussen-Torvik, Sarah A Pendergrass, Amy C Sturm, Bahram Namjou, Amy Sanghavi Shah, Robert J Carroll, Wendy K Chung, Wei-Qi Wei, QiPing Feng, C Michael Stein, Dan M Roden, Teri A Manolio, Daniel J Schaid, Joshua C Denny, Scott J Hebbring, Mariza de Andrade, Iftikhar J Kullo

Affiliations

  1. 1Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905 USA.
  2. 2Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield, WI 54449 USA.
  3. 3Department of Biomedical Informatics, Vanderbilt University, Nashville, TN 37235 USA.
  4. 4Department of Genetics, University of Pennsylvania, Philadelphia, PA 19111 USA.
  5. Department of Biomedical and Translational Informatics, Geisinger, Danville, PA 17821 USA.
  6. Genomic Medicine Institute, Geisinger, Danville, PA 17822 USA.
  7. 7Group Health Research Institute, Seattle, WA 98101 USA.
  8. 8Department of Medicine (Medical Genetics), University of Washington Medical Center, Seattle, WA 98195 USA.
  9. 9Department of Genome Sciences, University of Washington, Seattle, WA 98195 USA.
  10. Genetic Services, Kaiser Permanente of Washington, Seattle, WA 98122 USA.
  11. 11Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA.
  12. 12Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH 45229 USA.
  13. 13Division of Endocrinology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH 45229 USA.
  14. 14Department of Pediatrics, Columbia University, New York, NY 10032 USA.
  15. 15Department of Medicine, Columbia University, New York, NY 10032 USA.
  16. 16Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN 37232 USA.
  17. 17Department of Medicine, Vanderbilt University, Nashville, TN 37232 USA.
  18. 18Division of Genomic Medicine, National Human Genome Research Institute, Bethesda, MD 20892 USA.
  19. 19Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905 USA.
  20. 20Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI 54449 USA.

PMID: 30774981 PMCID: PMC6370860 DOI: 10.1038/s41525-019-0078-7

Abstract

We conducted an electronic health record (EHR)-based phenome-wide association study (PheWAS) to discover pleiotropic effects of variants in three lipoprotein metabolism genes

Conflict of interest statement

The authors declare no competing interests.

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